Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

(2021) Ming Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

VDR/Atg3 axis regulates slit diaphragm to tight junction transition via p62-mediated autophagy pathway in diabetic nephropathy

(2021) Bin Wang et al.   DIABETES

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria

(2021) Alvaro González‐Dominguez et al.   EMBO Molecular Medicine

Innate immunity in diabetic kidney disease

(2020) Sydney C. W. Tang et al.   Nature Reviews Nephrology

Role of Inflammasomes in Kidney Diseases via Both Canonical and Non-canonical Pathways

(2020) Huiling Xiang et al.   Frontiers in Cell and Developmental Biology

Recent advances in the NEK7-licensed NLRP3 inflammasome activation: Mechanisms, role in diseases and related inhibitors

(2020) Ni Zhao et al.   JOURNAL OF AUTOIMMUNITY

Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease

(2020) Shan Li et al.   JOURNAL OF PATHOLOGY

Targeting NLRP3 inflammasome as a promising approach for treatment of diabetic nephropathy: Preclinical evidences with therapeutic approaches

(2020) Chetan Ram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic nephropathy

(2019) Yun Hou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney

(2019) Yang Gyun Kim et al.   Cells

Diabetic kidney diseases revisited: A new perspective for a new era

(2019) Haiyan Fu et al.   Molecular Metabolism

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia

(2018) Mengyu Lai et al.   Frontiers in Aging Neuroscience

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

(2017) Syamantak Majumder et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation

(2017) Lourdes Álvarez-Arellano et al.   JOURNAL OF NEUROSCIENCE RESEARCH

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

(2017) Hong Yi et al.   Cell Death & Disease

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

MAVS maintains mitochondrial homeostasis via autophagy

(2016) Xiaofeng Sun et al.   Cell Discovery

Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy

(2016) Khurrum Shahzad et al.   Scientific Reports

Improved renal function in diabetic patients with acute gout treated with anakinra

(2015) Gowrie Balasubramaniam et al.   KIDNEY INTERNATIONAL

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Prediction of prevalence of chronic kidney disease in diabetic patients in countries of the European Union up to 2025

(2015) Alexander Kainz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy

(2014) Pan Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart

(2014) Stefano Toldo et al.   CARDIOVASCULAR RESEARCH

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Podocyte B7-1 in Diabetic Nephropathy

(2014) P. Fiorina et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

(2013) Shun-Min Yang et al.   DIABETOLOGIA

Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells

(2013) A. Goldwich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions

(2013) K. Yamahara et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

(2012) F. Bock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE