Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 885, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2020.173503
Keywords
Diabetic nephropathy; NLRP3 inflammasome; Inhibitors of NLRP3 inflammasome signal axis; Pro-inflammatory cytokines; Reactive oxygen species
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Funding
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India
- National Institute of Pharmaceutical Education and Research (NIPER) Guwahati, Assam, India
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Diabetes mellitus is an increasingly prevalent disease around the globe. The epidemic of diabetes mellitus and its complications pretenses the foremost health threat globally. Diabetic nephropathy is the notable complication in diabetes, leading to end-stage renal disease (ESRD) and premature death. Abundant experimental evidence indicates that oxidative stress and inflammation are the important mediators in diabetic kidney diseases and interlinked with various signal transduction molecular mechanisms. Inflammasomes are the critical components of innate immunity and are recognized as a critical mediator of inflammation and autoimmune disorders. NOD like receptor protein 3 (NLRP3) inflammasome is the well-characterized protein and it exhibits the sterile inflammation through the regulation of pro-inflammatory cytokines interleukin (IL)-1 beta and IL-18 production in tissues. In recent years, the role of NLRP3 inflammasome in the pathophysiology of diabetic kidney diseases in both clinical and experimental studies has generated great interest. In the current review, we focused on and discussed the role of NLRP3 inflammasome in diabetic nephropathy. A literature review was performed using online databases namely, PubMed, Scopus, Google Scholar and Web of science to explore the possible pharmacological interventions that blunt the NLRP3 inflammasome-caspase-1-IL-1 beta/IL-18 axis and shown to have a beneficial effect in diabetic kidney diseases. This review describes the inhibition of NLRP3 inflammasome activation as a promising therapeutic target for drug discovery in future.
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