Challenges and Future of Drug-Induced Liver Injury Research—Laboratory Tests

A Revised Electronic Version of RUCAM for the Diagnosis of Drug Induced Liver Injury

(2022) Paul H. Hayashi et al.   HEPATOLOGY

A novel phenotype‐based drug‐induced liver injury causality assessment tool ( DILI‐CAT ) allows for signal confirmation in early drug development

(2022) Richard P. Hermann et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

MicroRNA‐122 and cytokeratin‐18 have potential as a biomarkers of drug‐induced liver injury in European and African patients on treatment for mycobacterial infection

(2021) Sarah A.E. Rupprechter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans

(2021) Heather P Llewellyn et al.   TOXICOLOGICAL SCIENCES

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(2021) Naga P. Chalasani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges

(2021) Alison Jee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models

(2021) Alessio Gerussi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes

(2021) Guillermo Quintás et al.   ARCHIVES OF TOXICOLOGY

Circulatory Inflammatory Mediators in the Prediction of Anti-Tuberculous Drug-Induced Liver Injury Using RUCAM for Causality Assessment

(2021) Cheng-Maw Ho et al.   Biomedicines

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

(2021) Tim Brecklinghaus et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review

(2021) Edmond Atallah et al.   Expert Opinion on Drug Metabolism & Toxicology

Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways

(2021) Petar D. Petrov et al.   FOOD AND CHEMICAL TOXICOLOGY

Advanced preclinical models for evaluation of drug-induced liver injury – consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]

(2021) Jose C. Fernandez-Checa et al.   JOURNAL OF HEPATOLOGY

Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

(2020) Shelli Schomaker et al.   PLoS One

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

(2020) Ruben Boon et al.   Nature Communications

Antimitochondrial rather than antinuclear antibodies correlate with severe drug-induced liver injury

(2020) Sabine Weber et al.   DIGESTIVE DISEASES

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

(2020) Tadahiro Shinozawa et al.   GASTROENTEROLOGY

HLA‐B*35:01 and Green Tea Induced Liver Injury

(2020) Jay H. Hoofnagle et al.   HEPATOLOGY

Comparison of diagnostic accuracy of 3 diagnostic criteria combined with refined pathological scoring system for drug-induced liver injury

(2020) Yiqi Liu et al.   MEDICINE

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

(2020) Rachel J. Church et al.   PLoS One

Role of Mitochondria in the Redox Signaling Network and Its Outcomes in High Impact Inflammatory Syndromes

(2020) Natalia D. Magnani et al.   Frontiers in Endocrinology

Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study

(2020) Ying Huang et al.   Frontiers in Medicine

Tools for causality assessment in drug-induced liver disease

(2019) Hans L. Tillmann et al.   CURRENT OPINION IN GASTROENTEROLOGY

The DILI-sim Initiative: Insights into Hepatotoxicity Mechanisms and Biomarker Interpretation

(2019) Paul B. Watkins   CTS-Clinical and Translational Science

Metabolomics and Cytokine Analysis for Identification of Severe Drug-Induced Liver Injury

(2019) Zhongyang Xie et al.   JOURNAL OF PROTEOME RESEARCH

Next Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development

(2019) Sharin E. Roth et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

(2019) Seon Ju Mun et al.   JOURNAL OF HEPATOLOGY

Drug-Induced Liver Injury — Types and Phenotypes

(2019) Jay H. Hoofnagle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury

(2019) Zhenhua Ma et al.   MEDICINE

Lipotoxic Hepatocyte‐Derived Exosomal miR‐192‐5p Activates Macrophages via Rictor/Akt/FoxO1 Signaling in NAFLD

(2019) Xiao‐Lin Liu et al.   HEPATOLOGY

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury

(2019) Paul B. Watkins   Clinics in Liver Disease

Genetic Predisposition to Drug-Induced Liver Injury

(2019) Camilla Stephens et al.   Clinics in Liver Disease

Development and Validation of a Test to Identify Drugs That Cause Idiosyncratic Drug-Induced Liver Injury

(2018) Andreas Benesic et al.   Clinical Gastroenterology and Hepatology

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

(2018) Rachel J. Church et al.   HEPATOLOGY

Proteomics Analysis of Monocyte-Derived Hepatocyte-Like Cells Identifies Integrin Beta 3 as a Specific Biomarker for Drug-Induced Liver Injury by Diclofenac

(2018) Diana Dragoi et al.   Frontiers in Pharmacology

Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group

(2018) Herbert L. Bonkovsky et al.   PLoS One

Serum biomarkers of drug-induced liver injury: Current status and future directions

(2018) Rachel J. Church et al.   Journal of Digestive Diseases

MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury

(2017) Lawrence S. Howell et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

(2017) Paola Nicoletti et al.   GASTROENTEROLOGY

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

“Autoimmune(-Like)” Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗ 35:02 as a risk factor

(2017) Thomas Jacob Urban et al.   JOURNAL OF HEPATOLOGY

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response

(2017) Jessica Whritenour et al.   Journal of Immunotoxicology

Histopathological challenges in suspected drug-induced liver injury

(2017) David E. Kleiner   LIVER INTERNATIONAL

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

(2017) Rosa Chan et al.   TOXICOLOGICAL SCIENCES

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma

(2017) Anders Etzerodt et al.   Scientific Reports

Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening

(2016) María José Gómez-Lechón et al.   ARCHIVES OF TOXICOLOGY

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

(2016) Leonard J. Nelson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Oxidative stress markers, secondary bile acids and sulfated bile acids classify the clinical liver injury type: Promising diagnostic biomarkers for cholestasis

(2016) Noriko Masubuchi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance

(2016) Mark W. Russo et al.   LIVER INTERNATIONAL

Induced pluripotent stem cell technology: a decade of progress

(2016) Yanhong Shi et al.   NATURE REVIEWS DRUG DISCOVERY

HLA-DRB1*16

(2016) Paola Nicoletti et al.   Pharmacogenetics and Genomics

Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis

(2016) Camilla Stephens et al.   Pharmacogenetics and Genomics

Evaluation of IL-2, IL-10, IL-17 and IP-10 as potent discriminative markers for active tuberculosis among pulmonary tuberculosis suspects

(2016) Eunkyoung You et al.   TUBERCULOSIS

ImPortance of IP-10 in hepatitis B

(2015) Markus Cornberg et al.   ANTIVIRAL THERAPY

Population-Representative Incidence of Drug-Induced Acute Liver Failure Based on an Analysis of an Integrated Health Care System

(2015) David S. Goldberg et al.   GASTROENTEROLOGY

Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury

(2015) Andreas Benesic et al.   GUT

Microbial-derived lithocholic acid and vitamin K2drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes

(2015) Yishai Avior et al.   HEPATOLOGY

RUCAM in Drug and Herb Induced Liver Injury: The Update

(2015) Gaby Danan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EASL Clinical Practice Guidelines: Autoimmune hepatitis

(2015)   JOURNAL OF HEPATOLOGY

Comprehensive microRNA profiling in acetaminophen toxicity identifies novel circulating biomarkers for human liver and kidney injury

(2015) A. D. B. Vliegenthart et al.   Scientific Reports

Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

(2014) Mitchell R McGill et al.   Expert Opinion on Drug Metabolism & Toxicology

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C

(2014) Konstantin Kazankov et al.   HEPATOLOGY

A detection algorithm for drug-induced liver injury in medical information databases using the Japanese diagnostic scale and its comparison with the Council for International Organizations of Medical Sciences/the Roussel Uclaf Causality Assessment Method

(2014) Tadaaki Hanatani et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

(2014) Richard L. Gieseck III et al.   PLoS One

Drug-Induced Liver Injury with Autoimmune Features

(2014) David Foureau et al.   SEMINARS IN LIVER DISEASE

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital

(2013) Daniel J. Antoine et al.   HEPATOLOGY

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

(2013) Petra Thulin et al.   LIVER INTERNATIONAL

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

(2013) J CJ Martin et al.   Mucosal Immunology

Profiles of Serum Cytokines in Acute Drug-Induced Liver Injury and Their Prognostic Significance

(2013) Nury M. Steuerwald et al.   PLoS One

Serum proteomic profiling in patients with drug-induced liver injury

(2012) L. N. Bell et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

(2012) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers

(2012) A H Harrill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Soluble CD163: a biomarker linking macrophages and insulin resistance

(2012) T. Parkner et al.   DIABETOLOGIA

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

The contribution of oxidative stress to drug-induced organ toxicity and its detectionin vitroandin vivo

(2012) Claudia V Pereira et al.   Expert Opinion on Drug Metabolism & Toxicology

Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies

(2012) Andreas Benesic et al.   LABORATORY INVESTIGATION

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

(2012) Fei Yi et al.   Protein & Cell

Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

(2011) G P Aithal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury

(2011) Ayako Suzuki et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Causality assessment methods in drug induced liver injury: Strengths and weaknesses

(2011) Miren García-Cortés et al.   JOURNAL OF HEPATOLOGY

Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease

(2011) Tomoyoshi Soga et al.   JOURNAL OF HEPATOLOGY

Evidence for prostaglandin-producing suppressor cells in drug-induced liver injury and implications in the diagnosis of drug sensitization

(2010) R. M. M. VICTORINO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

Drug-induced autoimmune hepatitis: Clinical characteristics and prognosis

(2010) Einar Björnsson et al.   HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Biomarkers for drug-induced liver injury

(2010) Qiang Shi et al.   Expert Review of Gastroenterology & Hepatology

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Simplified criteria for the diagnosis of autoimmune hepatitis

(2008) Elke M. Hennes et al.   HEPATOLOGY

Muscular exercise can cause highly pathological liver function tests in healthy men

(2007) Jonas Pettersson et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY