The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

(2021) Kathrin Gianmoena et al.   Cell Reports

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

(2020) Gisela Campos et al.   ARCHIVES OF TOXICOLOGY

Vienna LiverTox Workspace—A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies

(2020) Floriane Montanari et al.   Frontiers in Chemistry

Intravital dynamic and correlative imaging reveals diffusion‐dominated canalicular and flow‐augmented ductular bile flux

(2020) Nachiket Vartak et al.   HEPATOLOGY

Handling deviating control values in concentration-response curves

(2020) Franziska Kappenberg et al.   ARCHIVES OF TOXICOLOGY

Road Map for Development of Stem Cell-Based Alternative Test Methods

(2019) Agapios Sachinidis et al.   TRENDS IN MOLECULAR MEDICINE

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

(2019) Wiebke Albrecht et al.   ARCHIVES OF TOXICOLOGY

Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification

(2018) Rosa Chan et al.   Toxicology Research

Bile micro-infarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood

(2018) Ahmed Ghallab et al.   HEPATOLOGY

Cellular Clearance and Biological Activity of Calciprotein Particles Depend on Their Maturation State and Crystallinity

(2018) Sina Köppert et al.   Frontiers in Immunology

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes

(2018) Xiaolong Gu et al.   ARCHIVES OF TOXICOLOGY

The ascending pathophysiology of cholestatic liver disease

(2017) Peter L.M. Jansen et al.   HEPATOLOGY

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

(2017) Rosa Chan et al.   TOXICOLOGICAL SCIENCES

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice

(2016) Raymond Reif et al.   ARCHIVES OF TOXICOLOGY

Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line

(2016) Pedro Caetano-Pinto et al.   MOLECULAR PHARMACEUTICS

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Evaluation of BEH C18, BEH HILIC, and HSS T3 (C18) Column Chemistries for the UPLC-MS-MS Analysis of Glutathione, Glutathione Disulfide, and Ophthalmic Acid in Mouse Liver and Human Plasma

(2013) L.-S. New et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

(2013) Sagnik Chatterjee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS