Modeling ALS with motor neurons derived from human induced pluripotent stem cells

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons

(2015) J. S. Toma et al.   JOURNAL OF NEUROSCIENCE

Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure

(2015) N. D. Amin et al.   SCIENCE

Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

(2015) Anna-Claire Devlin et al.   Nature Communications

Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells

(2015) Katrina L. Adams et al.   Nature Communications

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

(2015) Zhong-Wei Du et al.   Nature Communications

Deterministic HOX Patterning in Human Pluripotent Stem Cell-Derived Neuroectoderm

(2015) Ethan S. Lippmann et al.   Stem Cell Reports

Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons

(2014) Hong Chen et al.   Cell Stem Cell

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

(2014) Evangelos Kiskinis et al.   Cell Stem Cell

How to make spinal motor neurons

(2014) B. N. Davis-Dusenbery et al.   DEVELOPMENT

Active repression by RAR  signaling is required for vertebrate axial elongation

(2014) A. Janesick et al.   DEVELOPMENT

Wnt/ -catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse embryonic stem cells

(2014) D. A. Turner et al.   DEVELOPMENT

Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous neocortical-like neurons stalled at a stage equivalent to midcorticogenesis

(2014) Cameron Sadegh et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord

(2014) Dhruv Sareen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis after Suppression of Mutant SOD1 in the Motor Cortex

(2014) G. M. Thomsen et al.   JOURNAL OF NEUROSCIENCE

Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

(2014) Nicolas Delestrée et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes

(2014) Yves Maury et al.   NATURE BIOTECHNOLOGY

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

(2014) Jason L. Stein et al.   NEURON

Neurotrophic Requirements of Human Motor Neurons Defined Using Amplified and Purified Stem Cell-Derived Cultures

(2014) Nuno Jorge Lamas et al.   PLoS One

Coordination of progenitor specification and growth in mouse and chick spinal cord

(2014) A. Kicheva et al.   SCIENCE

Optical Control of Muscle Function by Transplantation of Stem Cell-Derived Motor Neurons in Mice

(2014) J. B. Bryson et al.   SCIENCE

Motor neurons and the generation of spinal motor neuron diversity

(2014) Nicolas Stifani   Frontiers in Cellular Neuroscience

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

(2014) Mina Gouti et al.   PLOS BIOLOGY

Derivation of Myogenic Progenitors Directly From Human Pluripotent Stem Cells Using a Sphere-Based Culture

(2014) Tohru Hosoyama et al.   Stem Cells Translational Medicine

Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

(2014) Félix Leroy et al.   eLife

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Developmental mechanisms directing early anterior forebrain specification in vertebrates

(2013) Cynthia Lilian Andoniadou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lhx2 Regulates the Development of the Forebrain Hem System

(2013) Achira Roy et al.   CEREBRAL CORTEX

The transcription factor Otx2 regulates choroid plexus development and function

(2013) P. A. Johansson et al.   DEVELOPMENT

Back to the future: how human induced pluripotent stem cells will transform regenerative medicine

(2013) C. N. Svendsen   HUMAN MOLECULAR GENETICS

In vitro-differentiated neural cell cultures progress towards donor-identical brain tissue

(2013) Brooke E. Hjelm et al.   HUMAN MOLECULAR GENETICS

The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

(2013) Jong Seok Bae et al.   Journal of Clinical Neurology

Lmo4 Establishes Rostral Motor Cortex Projection Neuron Subtype Diversity

(2013) G. Y. Cederquist et al.   JOURNAL OF NEUROSCIENCE

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

(2013) M. W. Amoroso et al.   JOURNAL OF NEUROSCIENCE

Role for Lhx2 in corticogenesis through regulation of progenitor differentiation

(2013) Shen-Ju Chou et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

(2013) Jackson Sandoe et al.   NATURE NEUROSCIENCE

Molecular logic of neocortical projection neuron specification, development and diversity

(2013) Luciano Custo Greig et al.   NATURE REVIEWS NEUROSCIENCE

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

(2013) Lowry A. Kirkby et al.   NEURON

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization

(2013) Polyxeni Philippidou et al.   NEURON

Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

(2013) Makoto Nasu et al.   PLoS One

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

(2013) Peter Reinhardt et al.   PLoS One

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Anatomic and Molecular Development of Corticostriatal Projection Neurons in Mice

(2012) U. Shivraj Sohur et al.   CEREBRAL CORTEX

Cortical neurogenesis and morphogens: diversity of cues, sources and functions

(2012) Luca Tiberi et al.   CURRENT OPINION IN CELL BIOLOGY

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron Dysfunction

(2012) R. G. Gogliotti et al.   JOURNAL OF NEUROSCIENCE

The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

(2012) J. Diaz-Alonso et al.   JOURNAL OF NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Maturation of Spinal Motor Neurons Derived from Human Embryonic Stem Cells

(2012) Tomonori Takazawa et al.   PLoS One

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice

(2012) M. Tirard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Loss of FGF-Dependent Mesoderm Identity and Rise of Endogenous Retinoid Signalling Determine Cessation of Body Axis Elongation

(2012) Isabel Olivera-Martinez et al.   PLOS BIOLOGY

Defining the nature of human pluripotent stem cell progeny

(2011) Michaela Patterson et al.   CELL RESEARCH

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

The role of Pax6 in forebrain development

(2011) Petrina A. Georgala et al.   Developmental Neurobiology

Corticospinal Motor Neurons and Related Subcerebral Projection Neurons Undergo Early and Specific Neurodegeneration in hSOD1G93A Transgenic ALS Mice

(2011) P. H. Ozdinler et al.   JOURNAL OF NEUROSCIENCE

Tbr1 and Fezf2 Regulate Alternate Corticofugal Neuronal Identities during Neocortical Development

(2011) W. L. McKenna et al.   JOURNAL OF NEUROSCIENCE

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells

(2011) David V. Hansen et al.   NEURON

The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells

(2011) Maria K. Lehtinen et al.   NEURON

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state

(2011) R. Patani et al.   Nature Communications

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

Mechanisms of neural specification from embryonic stem cells

(2010) Nicolas Gaspard et al.   CURRENT OPINION IN NEUROBIOLOGY

ALS pathogenesis: Recent insights from genetics and mouse models

(2010) Vivek Swarup et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inhibition of Notch Signaling in Human Embryonic Stem Cell-Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

(2010) Lodovica Borghese et al.   STEM CELLS

Development, specification, and diversity of callosal projection neurons

(2010) Ryann M. Fame et al.   TRENDS IN NEUROSCIENCES

Redefining the Progression of Lineage Segregations during Mammalian Embryogenesis by Clonal Analysis

(2009) Elena Tzouanacou et al.   DEVELOPMENTAL CELL

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

(2009) Eiman Azim et al.   NATURE NEUROSCIENCE

Generation of cortical neurons from mouse embryonic stem cells

(2009) Nicolas Gaspard et al.   Nature Protocols

Differentiation of spinal motor neurons from pluripotent human stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex

(2009) Ronald S. Bultje et al.   NEURON

Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1G93A ALS mouse model

(2009) C.R. Hayworth et al.   NEUROSCIENCE

Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation

(2009) Jessica L. MacDonald et al.   PROGRESS IN NEUROBIOLOGY

Cortical hyperexcitability may precede the onset of familial amyotrophic lateral sclerosis

(2008) Steve Vucic et al.   BRAIN

Hox Repertoires for Motor Neuron Diversity and Connectivity Gated by a Single Accessory Factor, FoxP1

(2008) Jeremy S. Dasen et al.   CELL

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

A Novel Purification Method for CNS Projection Neurons Leads to the Identification of Brain Vascular Cells as a Source of Trophic Support for Corticospinal Motor Neurons

(2008) J. C. Dugas et al.   JOURNAL OF NEUROSCIENCE

Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis

(2008) B. van Zundert et al.   JOURNAL OF NEUROSCIENCE

Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex

(2008) Kazue Hashimoto-Torii et al.   NEURON

The Fezf2-Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex

(2008) B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE