Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis

(2020) Marta Cherubini et al.   NEUROBIOLOGY OF DISEASE

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction

(2020) Rhia Ghosh et al.   FASEB JOURNAL

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia

(2020) Olga Kopach et al.   JOURNAL OF CELL SCIENCE

Cell-to-Cell Transmission of Tau and α-Synuclein

(2020) Norihito Uemura et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial and Redox-Based Therapeutic Strategies in Huntington's Disease

(2020) Lígia Fão et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective Effects of Antioxidants in Huntington’s Disease: an Extensive Review

(2019) Musthafa Mohamed Essa et al.   NEUROTOXICITY RESEARCH

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

(2019) Bindu D. Paul et al.   Frontiers in Molecular Neuroscience

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

(2019) Liyan Hou et al.   Redox Biology

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

(2019) Yan Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular mechanisms of complex I-associated pathology

(2019) Andrey Y. Abramov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

(2018) Franziska Kundel et al.   ACS Chemical Neuroscience

Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases

(2018) Minee L. Choi et al.   FEBS Journal

A Systematic DFT Study of Some Plausible Zn(II) and Al(III) Interaction Sites in N-Terminally Acetylated α-Synuclein

(2018) Rafael Ramis et al.   JOURNAL OF PHYSICAL CHEMISTRY A

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers

(2018) Daniel R. Whiten et al.   Cell Reports

Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation

(2018) Plamena R. Angelova et al.   Redox Biology

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Tau Phosphorylation, Molecular Chaperones, and Ubiquitin E3 Ligase: Clinical Relevance in Alzheimer's Disease

(2018) Pravir Kumar et al.   JOURNAL OF ALZHEIMERS DISEASE

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

(2018) Ju Zheng et al.   Frontiers in Molecular Neuroscience

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

(2017) Miranda E. Orr et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration

(2017) Noemí Esteras et al.   Redox Biology

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

(2017) Francesco A. Aprile et al.   Scientific Reports

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

(2016) Emma Deas et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

(2016) Noemí Esteras et al.   BIOLOGICAL CHEMISTRY

Deficiency of Parkinson’s disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

(2016) Marta Delgado-Camprubi et al.   CELL DEATH AND DIFFERENTIATION

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ca2+is a key factor in α-synuclein-induced neurotoxicity

(2016) Plamena R. Angelova et al.   JOURNAL OF CELL SCIENCE

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Transcriptional control of amino acid homeostasis is disrupted in Huntington’s disease

(2016) Juan I. Sbodio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROS Produced by NOX2 Controls In Vitro Development of Cerebellar Granule Neurons Development

(2015) Mauricio Olguín-Albuerne et al.   ASN Neuro

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

Lipid peroxidation is essential for α-synuclein-induced cell death

(2015) Plamena R. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

(2014) Bindu D. Paul et al.   NATURE

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Copper–amyloid-β complex may catalyze peroxynitrite production in brain: evidence from molecular modeling

(2014) Roberto Giacovazzi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease

(2013) Florian Haun et al.   ANTIOXIDANTS & REDOX SIGNALING

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

(2012) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

Antioxidants in Huntington's disease

(2011) Ashu Johri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

In Vitroandin VivoAggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production

(2011) Sarah Hands et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Important Role of Oxidative Stress Biomarkers in Huntington’s Disease

(2011) Isaac Túnez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity

(2011) M. Ionov et al.   NEUROSCIENCE

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death

(2010) Sami Reijonen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Early and Late Events Induced by PolyQ-expanded Proteins

(2010) Alessandra Bertoni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stable α-Synuclein Oligomers Strongly Inhibit Chaperone Activity of the Hsp70 System by Weak Interactions with J-domain Co-chaperones

(2010) Marie-Pierre Hinault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Combined expression of tau and the Harlequin mouse mutation leads to increased mitochondrial dysfunction, tau pathology and neurodegeneration

(2009) Luka Kulic et al.   NEUROBIOLOGY OF AGING

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

(2009) Bo Su et al.   NEUROSCIENCE LETTERS

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH