Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

(2015) Irida Kastrati et al.   BMC CANCER

PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres

(2014) I Kastrati et al.   ONCOGENE

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

(2013) Douglas Marcotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Santonin-Related Compound 2 Inhibits the Nuclear Translocation of NF-κB Subunit p65 by Targeting Cysteine 38 in TNF-α-Induced NF-κB Signaling Pathway

(2012) Ryuichi TAMURA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minireview: Inflammation: An Instigator of More Aggressive Estrogen Receptor (ER) Positive Breast Cancers

(2012) Sarah C. Baumgarten et al.   MOLECULAR ENDOCRINOLOGY

ErbB receptor tyrosine kinase/NF- B signaling controls mammosphere formation in human breast cancer

(2012) K. Hinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Breast Cancer Stem Cells in Metastasis and Therapeutic Implications

(2011) Marco A. Velasco-Velázquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

CBP Mediates NF- B-Dependent Histone Acetylation and Estrogen Receptor Recruitment to an Estrogen Response Element in the BIRC3 Promoter

(2011) M. Pradhan et al.   MOLECULAR AND CELLULAR BIOLOGY

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

(2011) J. I. Herschkowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear NF- B/p65 expression and response to neoadjuvant chemotherapy in breast cancer

(2010) R. L. Jones et al.   JOURNAL OF CLINICAL PATHOLOGY

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Genome-Wide Analysis of Estrogen Receptor   DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation

(2010) J. D. Stender et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimethylfumarate inhibits NF-κB function at multiple levels to limit airway smooth muscle cell cytokine secretion

(2009) P. Seidel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies

(2009) Brett G. Hollier et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Modification of Cysteine Residue in p65 Subunit of Nuclear Factor-κB (NF-κB) by Picroliv Suppresses NF-κB–Regulated Gene Products and Potentiates Apoptosis

(2008) Preetha Anand et al.   CANCER RESEARCH

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Cancer stem cells: implications for the progression and treatment of metastatic disease

(2008) A.K Croker et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens

(2008) Marion G. Götz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inactivation of NF-κB Components by Covalent Binding of (−)-Dehydroxymethylepoxyquinomicin to Specific Cysteine Residues

(2008) Mizuki Yamamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Cancer Stem Cells in Breast: Current Opinion and Future Challenges

(2008) Emmanuelle Charafe-Jauffret et al.   PATHOBIOLOGY