Dimethyl fumarate, a two-edged drug: Current status and future directions

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma

(2018) Yu Sun et al.   CANCER LETTERS

Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat

(2018) Neha Singh et al.   EPILEPSY RESEARCH

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis

(2018) Tetsuo Toyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dimethyl Fumarate Attenuates Neuroinflammation and Neurobehavioral Deficits Induced by Experimental Traumatic Brain Injury

(2018) Giovanna Casili et al.   JOURNAL OF NEUROTRAUMA

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition

(2018) Mohammed Selman et al.   Science Translational Medicine

Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells

(2018) Nathaniel Edward Bennett Saidu et al.   Oncotarget

The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis

(2018) Anna Hammer et al.   Annals of Clinical and Translational Neurology

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma

(2018) Niloufar Kavian et al.   Frontiers in Immunology

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Dimethyl Fumarate Controls the NRF2/DJ-1 Axis in Cancer Cells: Therapeutic Applications

(2017) Nathaniel Edward Bennett Saidu et al.   MOLECULAR CANCER THERAPEUTICS

Hydroxy-Carboxylic Acid Receptor Actions in Metabolism

(2017) Stefan Offermanns   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation

(2016) Xiuting Liu et al.   BIOCHEMICAL PHARMACOLOGY

Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB

(2016) Jan P. Nicolay et al.   BLOOD

Dimethylfumarate induces cell cycle arrest and apoptosis via regulating intracellular redox systems in HeLa cells

(2016) Guocan Han et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

(2016) Jiemeng Lin-Holderer et al.   NEUROPHARMACOLOGY

The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

(2016) A. L. Furfaro et al.   Oxidative Medicine and Cellular Longevity

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Ruxolitinib synergizes with DMF to kill via BIM+BAD-induced mitochondrial dysfunction and via reduced SOD2/TRX expression and ROS

(2016) Mehrad Tavallai et al.   Oncotarget

A Metabolic Roadblock in Inflammatory Macrophages

(2016) Luke A.J. O’Neill   Cell Reports

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

(2016) Ralf A. Linker et al.   Therapeutic Advances in Chronic Disease

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

(2016) Victoria A. McGuire et al.   Scientific Reports

DJ-1 as a human oncogene and potential therapeutic target

(2015) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer

(2015) Marjo Pylväs-Eerola et al.   BMC CANCER

Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway

(2015) Xin Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dimethyl fumarate attenuates cerebral edema formation by protecting the blood–brain barrier integrity

(2015) Reiner Kunze et al.   EXPERIMENTAL NEUROLOGY

Glyceraldehyde-3-phosphate dehydrogenase is required for efficient repair of cytotoxic DNA lesions in Escherichia coli

(2015) Elaine Ferreira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein

(2015) Irida Kastrati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving Prospects for Targeting RAS

(2015) Harshabad Singh et al.   JOURNAL OF CLINICAL ONCOLOGY

DMF, but not other fumarates, inhibits NF-κB activity in vitro in an Nrf2-independent manner

(2015) Geoffrey O. Gillard et al.   JOURNAL OF NEUROIMMUNOLOGY

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection

(2015) Kalliopi Pitarokoili et al.   PLoS One

Dimethyl Fumarate Protects Brain From Damage Produced by Intracerebral Hemorrhage by Mechanism Involving Nrf2

(2015) Xiurong Zhao et al.   STROKE

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

(2015) Erin E Longbrake et al.   Multiple Sclerosis Journal

Involvement of CD8+ T Cells in Multiple Sclerosis

(2015) Marion Salou et al.   Frontiers in Immunology

Identification of protein succination as a novel modification of tubulin

(2014) Gerardo G. Piroli et al.   BIOCHEMICAL JOURNAL

Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP

(2014) Masanobu Tsubaki et al.   BIOMEDICINE & PHARMACOTHERAPY

Regulation of dimethyl-fumarate toxicity by proteasome inhibitors

(2014) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation

(2014) Christiane Reick et al.   EXPERIMENTAL NEUROLOGY

Moonlighting cell-surface GAPDH recruits apotransferrin to effect iron egress from mammalian cells

(2014) N. Sheokand et al.   JOURNAL OF CELL SCIENCE

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

(2014) Hui Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Detection of fumarate–glutathione adducts in the portal vein blood of rats: evidence for rapid dimethylfumarate metabolism

(2013) Stefan Dibbert et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

Crosstalk between the Type 1 Interferon and Nuclear Factor Kappa B Pathways Confers Resistance to a Lethal Virus Infection

(2013) Daniel Rubio et al.   Cell Host & Microbe

Dimethyl Fumarate for Treatment of Multiple Sclerosis: Mechanism of Action, Effectiveness, and Side Effects

(2013) Ralf A. Linker et al.   Current Neurology and Neuroscience Reports

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

The succinated proteome

(2013) Eric D. Merkley et al.   MASS SPECTROMETRY REVIEWS

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

SOD1 and DJ-1 Converge at Nrf2 Pathway: A Clue for Antioxidant Therapeutic Potential in Neurodegeneration

(2013) Pamela Milani et al.   Oxidative Medicine and Cellular Longevity

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

(2012) Norma Frizzell et al.   BIOCHEMICAL JOURNAL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

(2012) Houman Ashrafian et al.   Cell Metabolism

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling

(2012) Haiyan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evidence for a role of B cells in multiple sclerosis

(2012) G. Disanto et al.   NEUROLOGY

Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis

(2012) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

(2012) Ralf Gold et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

(2011) Lisa Kinch et al.   CANCER CELL

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

(2011) P. A. Konstantinopoulos et al.   CANCER RESEARCH

Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells

(2011) Kamran Ghoreschi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

(2011) Chiara Bardella et al.   JOURNAL OF PATHOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

(2011) Richard Possemato et al.   NATURE

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease

(2011) Gisa Ellrichmann et al.   PLoS One

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

High Levels of Nrf2 Determine Chemoresistance in Type II Endometrial Cancer

(2010) T. Jiang et al.   CANCER RESEARCH

Redox active secondary metabolites

(2010) Claus Jacob et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Dimethyl fumarate for multiple sclerosis

(2010) Athina Papadopoulou et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice

(2010) Julien Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

(2010) Henrik Wilms et al.   Journal of Neuroinflammation

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

(2010) Ohad Yogev et al.   PLOS BIOLOGY

Dimethylfumarate inhibits tumor cell invasion and metastasis by suppressing the expression and activities of matrix metalloproteinases in melanoma cells

(2009) Yuzuru Yamazoe et al.   CELL BIOLOGY INTERNATIONAL

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes

(2009) Norma Frizzell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

(2009) Dung-Fang Lee et al.   MOLECULAR CELL

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

(2008) A. Singh et al.   CANCER RESEARCH

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) Ludwig Kappos et al.   LANCET

Oxidative insults induce DJ-1 upregulation and redistribution: Implications for neuroprotection

(2008) Nirit Lev et al.   NEUROTOXICOLOGY