The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators

(2022) Ellen Youngsoo Rim et al.   Annual Review of Biochemistry

Lewis Wolpert (1929-2021)

(2021) J. C. Smith   DEVELOPMENT

Lewis Wolpert (1929–2021)

(2021) Claudio D. Stern   DEVELOPMENTAL CELL

Lewis Wolpert (1929–2021)

(2021) Cheryll Tickle et al.   SCIENCE

Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

(2021) Jack F Cazet et al.   eLife

Dinoflagellate symbionts escape vomocytosis by host cell immune suppression

(2021) Marie R. Jacobovitz et al.   Nature Microbiology

Cell Biology of Canonical Wnt Signaling

(2021) Lauren V. Albrecht et al.   Annual Review of Cell and Developmental Biology

The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra

(2021) Berenice Ziegler et al.   BMC BIOLOGY

Ensemble synchronization in the reassembly of Hydra’s nervous system

(2021) Jonathan R. Lovas et al.   CURRENT BIOLOGY

Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration in Hydra

(2021) Matthias Christian Vogg et al.   Cold Spring Harbor Perspectives in Biology

Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning

(2021) Tatiana Lebedeva et al.   Nature Communications

Neuropeptide repertoire and 3D anatomy of the ctenophore nervous system

(2021) Maria Y. Sachkova et al.   CURRENT BIOLOGY

Growth across scales: Dynamic signaling impacts tissue size and shape

(2021) Rita Mateus et al.   CURRENT OPINION IN CELL BIOLOGY

The role of Xenopus developmental biology in unraveling Wnt signalling and antero-posterior axis formation

(2021) Christof Niehrs   DEVELOPMENTAL BIOLOGY

Systems of pattern formation within developmental biology

(2021) Kristofor Pas et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The colonial cnidarian Hydractinia

(2020) Uri Frank et al.   EvoDevo

Deeply conserved synteny resolves early events in vertebrate evolution

(2020) Oleg Simakov et al.   Nature Ecology & Evolution

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

(2020) Ian J. McGough et al.   NATURE

Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelid Capitella teleta

(2020) Alexis R. Lanza et al.   DEVELOPMENT

Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles

(2020) Lakshmi Surekha Krishnapati et al.   DEVELOPMENTAL DYNAMICS

Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians

(2020) Ulrich Technau   MECHANISMS OF DEVELOPMENT

Bacteria- and temperature-regulated peptides modulate β-catenin signaling inHydra

(2020) Jan Taubenheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra

(2019) Matthias C. Vogg et al.   Nature Communications

Acoel genome reveals the regulatory landscape of whole-body regeneration

(2019) Andrew R. Gehrke et al.   SCIENCE

The draft genome of an octocoral, Dendronephthya gigantea

(2019) Yeonsu Jeon et al.   Genome Biology and Evolution

The genome of the jellyfish Clytia hemisphaerica and the evolution of the cnidarian life-cycle

(2019) Lucas Leclère et al.   Nature Ecology & Evolution

Mapping the Whole-Body Muscle Activity of Hydra vulgaris

(2019) John R. Szymanski et al.   CURRENT BIOLOGY

Mechanisms of intercellular Wnt transport

(2019) Daniel Routledge et al.   DEVELOPMENT

The Whole-Genome Sequence of the Coral Acropora millepora

(2019) Hua Ying et al.   Genome Biology and Evolution

A hybrid de novo assembly of the sea pansy (Renilla muelleri) genome

(2019) Justin B Jiang et al.   GigaScience

Medusozoan genomes inform the evolution of the jellyfish body plan

(2019) Konstantin Khalturin et al.   Nature Ecology & Evolution

Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems

(2019) Fabian Rentzsch et al.   CURRENT OPINION IN NEUROBIOLOGY

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

(2019) Stefan Siebert et al.   SCIENCE

Box, stalked, and upside-down? Draft genomes from diverse jellyfish (Cnidaria, Acraspeda) lineages: Alatina alata (Cubozoa), Calvadosia cruxmelitensis (Staurozoa), and Cassiopea xamachana (Scyphozoa)

(2019) Aki Ohdera et al.   GigaScience

A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis

(2019) Eisuke Hayakawa et al.   PLoS One

Chromatin dynamics enable transcriptional rhythms in the cnidarian Nematostella vectensis

(2019) Eviatar N. Weizman et al.   PLoS Genetics

Cnidarian Cell Type Diversity and Regulation Revealed by Whole-Organism Single-Cell RNA-Seq

(2018) Arnau Sebé-Pedrós et al.   CELL

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

YAP/TAZ upstream signals and downstream responses

(2018) Antonio Totaro et al.   NATURE CELL BIOLOGY

Wound redox gradients revisited

(2018) Philipp Niethammer   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Redox signalling in development and regeneration

(2018) Sophie Vriz   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Making head or tail of cnidarian hox gene function

(2018) Fabian Rentzsch et al.   Nature Communications

Hox and Wnt pattern the primary body axis of an anthozoan cnidarian before gastrulation

(2018) Timothy Q. DuBuc et al.   Nature Communications

Reconstruction of the ancestral metazoan genome reveals an increase in genomic novelty

(2018) Jordi Paps et al.   Nature Communications

Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development

(2018) Sébastien Darras et al.   PLOS BIOLOGY

Comprehensive machine learning analysis of Hydra behavior reveals a stable basal behavioral repertoire

(2018) Shuting Han et al.   eLife

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

Hydra Mesoglea Proteome Identifies Thrombospondin as a Conserved Component Active in Head Organizer Restriction

(2018) Mark Lommel et al.   Scientific Reports

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Evolution of the bilaterian mouth and anus

(2018) Claus Nielsen et al.   Nature Ecology & Evolution

Morphomechanical rules of embryonic development

(2018) Lev V. Beloussov   BIOSYSTEMS

Evolution: Directives from Sea Anemone Hox Genes

(2018) Ulrich Technau et al.   CURRENT BIOLOGY

TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

(2018) Nikolaos Doumpas et al.   EMBO JOURNAL

The genome of the jellyfish Aurelia and the evolution of animal complexity

(2018) David A. Gold et al.   Nature Ecology & Evolution

Back to the Basics: Cnidarians Start to Fire

(2017) Thomas C.G. Bosch et al.   TRENDS IN NEUROSCIENCES

The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells

(2017) Ian J. Huggins et al.   Nature Communications

Gut-like ectodermal tissue in a sea anemone challenges germ layer homology

(2017) Patrick R. H. Steinmetz et al.   Nature Ecology & Evolution

Ctenophore relationships and their placement as the sister group to all other animals

(2017) Nathan V. Whelan et al.   Nature Ecology & Evolution

Dating early animal evolution using phylogenomic data

(2017) Martin Dohrmann et al.   Scientific Reports

Surprisingly rich repertoire of Wnt genes in the demosponge Halisarca dujardini

(2016) Ilya Borisenko et al.   BMC EVOLUTIONARY BIOLOGY

Genomics and development of Nematostella vectensis and other anthozoans

(2016) Fabian Rentzsch et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Xenacoelomorpha is the sister group to Nephrozoa

(2016) Johanna Taylor Cannon et al.   NATURE

Phylogenetic evidence for the modular evolution of metazoan signalling pathways

(2016) Leslie S. Babonis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pre-bilaterian origin of the blastoporal axial organizer

(2016) Yulia Kraus et al.   Nature Communications

The cellular and molecular basis of cnidarian neurogenesis

(2016) Fabian Rentzsch et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The organizer in evolution–gastrulation and organizer gene expression highlight the importance of Brachyury during development of the coral, Acropora millepora

(2015) David C. Hayward et al.   DEVELOPMENTAL BIOLOGY

Dorsoventral patterning by the Chordin-BMP pathway: a unified model from a pattern-formation perspective for drosophila, vertebrates, sea urchins and nematostella

(2015) Hans Meinhardt   DEVELOPMENTAL BIOLOGY

A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration

(2015) Hendrik O. Petersen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Hemichordate genomes and deuterostome origins

(2015) Oleg Simakov et al.   NATURE

RGM co-receptors add complexity to BMP signaling

(2015) Thomas D Mueller   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution of eumetazoan nervous systems: insights from cnidarians

(2015) Iva Kelava et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genomic data do not support comb jellies as the sister group to all other animals

(2015) Davide Pisani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genome ofAiptasia, a sea anemone model for coral symbiosis

(2015) Sebastian Baumgarten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Models for patterning primary embryonic body axes: The role of space and time

(2015) Hans Meinhardt   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The hidden biology of sponges and ctenophores

(2015) Casey W. Dunn et al.   TRENDS IN ECOLOGY & EVOLUTION

RGM co-receptors add complexity to BMP signaling

(2015) Thomas D Mueller   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints

(2015) Grigory Genikhovich et al.   Cell Reports

Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche

(2015) Su Wang et al.   eLife

Evolution, divergence and loss of the Nodal signalling pathway: new data and a synthesis across the Bilateria

(2015) Cristina Grande et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Animal Phylogeny and Its Evolutionary Implications

(2014) Casey W. Dunn et al.   Annual Review of Ecology Evolution and Systematics

The Analysis of Eight Transcriptomes from All Poriferan Classes Reveals Surprising Genetic Complexity in Sponges

(2014) Ana Riesgo et al.   MOLECULAR BIOLOGY AND EVOLUTION

The ctenophore genome and the evolutionary origins of neural systems

(2014) Leonid L. Moroz et al.   NATURE

Nodal signalling determines biradial asymmetry in Hydra

(2014) Hiroshi Watanabe et al.   NATURE

Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis

(2014) Hiroshi Watanabe et al.   Nature Communications

Developmental gene expression provides clues to relationships between sponge and eumetazoan body plans

(2014) Sven Leininger et al.   Nature Communications

RGM Regulates BMP-Mediated Secondary Axis Formation in the Sea Anemone Nematostella vectensis

(2014) Lucas Leclère et al.   Cell Reports

Differential Responses to Wnt and PCP Disruption Predict Expression and Developmental Function of Conserved and Novel Genes in a Cnidarian

(2014) Pascal Lapébie et al.   PLoS Genetics

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis

(2013) Heather Marlow et al.   DEVELOPMENTAL BIOLOGY

Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo

(2013) J.-L. Plouhinec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolution

(2013) J. F. Ryan et al.   SCIENCE

The Bilaterian Head Patterning Gene six3/6 Controls Aboral Domain Development in a Cnidarian

(2013) Chiara Sinigaglia et al.   PLOS BIOLOGY

Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation

(2012) Xinjun Zhang et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Interstitial stem cells in Hydra: multipotency and decision-making

(2012) Charles N. David   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Modeling pattern formation in hydra: a route to understanding essential steps in development

(2012) Hans Meinhardt   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Proteome of Hydra Nematocyst

(2012) Prakash G. Balasubramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into bilaterian evolution from three spiralian genomes

(2012) Oleg Simakov et al.   NATURE

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

The Evolution of the Wnt Pathway

(2012) T. W. Holstein   Cold Spring Harbor Perspectives in Biology

Turing's theory of morphogenesis of 1952 and the subsequent discovery of the crucial role of local self-enhancement and long-range inhibition

(2012) H. Meinhardt   Interface Focus

The Multiple Origins of Complex Multicellularity

(2011) Andrew H. Knoll   Annual Review of Earth and Planetary Sciences

Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation

(2011) Ralf Janssen et al.   BMC EVOLUTIONARY BIOLOGY

The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages

(2011) Ying-fu Zhong et al.   BMC EVOLUTIONARY BIOLOGY

Evolutionary crossroads in developmental biology: Cnidaria

(2011) U. Technau et al.   DEVELOPMENT

Nervous systems of the sea anemone Nematostella vectensis are generated by ectoderm and endoderm and shaped by distinct mechanisms

(2011) N. Nakanishi et al.   DEVELOPMENT

Wnt gene loss in flatworms

(2011) Nick Riddiford et al.   DEVELOPMENT GENES AND EVOLUTION

Mathematics and biology: a Kantian view on the history of pattern formation theory

(2011) Siegfried Roth   DEVELOPMENT GENES AND EVOLUTION

Functional roles of Notch signaling in the cnidarian Nematostella vectensis

(2011) Heather Marlow et al.   DEVELOPMENTAL BIOLOGY

Temporal pattern of the posterior expression of Wingless in Drosophila blastoderm

(2011) Peggy P. Vorwald-Denholtz et al.   GENE EXPRESSION PATTERNS

Using the Acropora digitifera genome to understand coral responses to environmental change

(2011) Chuya Shinzato et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer

(2011) Y. Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Polarized Epithelium Organized by  - and  -Catenin Predates Cadherin and Metazoan Origins

(2011) D. J. Dickinson et al.   SCIENCE

A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location

(2010) Nina D Schaeper et al.   BMC EVOLUTIONARY BIOLOGY

Wnt signaling promotes oral but suppresses aboral structures in Hydractinia metamorphosis and regeneration

(2010) D. J. Duffy et al.   DEVELOPMENT

On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes

(2010) C. Niehrs   DEVELOPMENT

Hydra Peptide Project 1993-2007

(2010) Toshitaka Fujisawa   DEVELOPMENT GROWTH & DIFFERENTIATION

Cnidarians and the evolutionary origin of the nervous system

(2010) Hiroshi Watanabe et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation response

(2010) Kyle A. Gurley et al.   DEVELOPMENTAL BIOLOGY

Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

(2010) Maja Adamska et al.   EVOLUTION & DEVELOPMENT

On the origin and evolution of the lower Metazoa

(2010) Luitfried V. Salvini-Plawen   JOURNAL OF ZOOLOGICAL SYSTEMATICS AND EVOLUTIONARY RESEARCH

Evolutionary Dynamics of the wnt Gene Family: A Lophotrochozoan Perspective

(2010) S.-J. Cho et al.   MOLECULAR BIOLOGY AND EVOLUTION

Unexpected Repertoire of Metazoan Transcription Factors in the Unicellular Holozoan Capsaspora owczarzaki

(2010) A. Sebe-Pedros et al.   MOLECULAR BIOLOGY AND EVOLUTION

The dynamic genome of Hydra

(2010) Jarrod A. Chapman et al.   NATURE

New tricks with old genes: the genetic bases of novel cnidarian traits

(2010) Sylvain Forêt et al.   TRENDS IN GENETICS

A genomic view of 500 million years of cnidarian evolution

(2010) Robert E. Steele et al.   TRENDS IN GENETICS

Beta-catenin and axis formation in planarians

(2009) Hans Meinhardt   BIOESSAYS

Phylogenomics Revives Traditional Views on Deep Animal Relationships

(2009) Hervé Philippe et al.   CURRENT BIOLOGY

Towards an integrated view of Wnt signaling in development

(2009) R. van Amerongen et al.   DEVELOPMENT

Origins of neurogenesis, a cnidarian view

(2009) Brigitte Galliot et al.   DEVELOPMENTAL BIOLOGY

Multiple Wnts are involved in Hydra organizer formation and regeneration

(2009) Tobias Lengfeld et al.   DEVELOPMENTAL BIOLOGY

Sailing with the Wnt: Charting the Wnt processing and secretion route

(2009) Magdalena J. Lorenowicz et al.   EXPERIMENTAL CELL RESEARCH

Regeneration: Thomas Hunt Morgan’s Window into Development

(2009) Mary Evelyn Sunderland   JOURNAL OF THE HISTORY OF BIOLOGY

Spemann’s organizer and the self-regulation of embryonic fields

(2009) E.M. De Robertis   MECHANISMS OF DEVELOPMENT

BMPs and Chordin regulate patterning of the directive axis in a sea anemone

(2009) M. Saina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/ -Catenin and noncanonical Wnt signaling interact in tissue evagination in the simple eumetazoan Hydra

(2009) I. Philipp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immortality and the base of multicellular life: Lessons from cnidarian stem cells

(2009) Hiroshi Watanabe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway

(2009) Isabelle Roszko et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cnidocyst structure and the biomechanics of discharge

(2009) Suat Özbek et al.   TOXICON

Models for the Generation and Interpretation of Gradients

(2009) H. Meinhardt   Cold Spring Harbor Perspectives in Biology

Nodal Morphogens

(2009) A. F. Schier   Cold Spring Harbor Perspectives in Biology

Evo-Devo: Variations on Ancestral Themes

(2008) E.M. De Robertis   CELL

Silencing of Smed- catenin1 generates radial-like hypercephalized planarians

(2008) M. Iglesias et al.   DEVELOPMENT

A maternally localised Wnt ligand required for axial patterning in the cnidarian Clytia hemisphaerica

(2008) T. Momose et al.   DEVELOPMENT

Lefty acts as an essential modulator of Nodal activity during sea urchin oral–aboral axis formation

(2008) Véronique Duboc et al.   DEVELOPMENTAL BIOLOGY

A Wnt-FoxQ2-Nodal Pathway Links Primary and Secondary Axis Specification in Sea Urchin Embryos

(2008) Shunsuke Yaguchi et al.   DEVELOPMENTAL CELL

Regulation of Wnt protein secretion and its role in gradient formation

(2008) Kerstin Bartscherer et al.   EMBO REPORTS

Nodal signalling is involved in left–right asymmetry in snails

(2008) Cristina Grande et al.   NATURE

The Trichoplax genome and the nature of placozoans

(2008) Mansi Srivastava et al.   NATURE

Heads or tails: can Wnt tell which one is up?

(2008) Elly M. Tanaka et al.   NATURE CELL BIOLOGY

The Premetazoan Ancestry of Cadherins

(2008) Monika Abedin et al.   SCIENCE

On the eve of animal radiation: phylogeny, ecology and evolution of the Ediacara biota

(2008) Shuhai Xiao et al.   TRENDS IN ECOLOGY & EVOLUTION

Evolution of complex structures: minicollagens shape the cnidarian nematocyst

(2008) Charles N. David et al.   TRENDS IN GENETICS

 -Catenin Defines Head Versus Tail Identity During Planarian Regeneration and Homeostasis

(2007) K. A. Gurley et al.   SCIENCE

Smed- catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

(2007) C. P. Petersen et al.   SCIENCE