Mechanisms of intercellular Wnt transport

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

(2019) Karol Kaiser et al.   Nature Communications

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

(2018) Ana-Citlali Gradilla et al.   BMC BIOLOGY

ERAD‐dependent control of the Wnt secretory factor Evi

(2018) Kathrin Glaeser et al.   EMBO JOURNAL

PDGFRα+pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

(2018) Gediminas Greicius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes in Cancer Liquid Biopsy: A Focus on Breast Cancer

(2018) Sina Halvaei et al.   Molecular Therapy-Nucleic Acids

Emerging role of contact-mediated cell communication in tissue development and diseases

(2018) Benjamin Mattes et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

(2018) Ariel M Pani et al.   eLife

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance

(2018) Y.-B. Hu et al.   ONCOGENE

Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding

(2017) Aaron H. Nile et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

(2017) Mark A. Wilson   STRUCTURE

Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport

(2017) Andreas Naschberger et al.   STRUCTURE

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS

(2017) Nardos G. Tassew et al.   Cell Reports

Cytoneme-mediated cell-cell contacts for Hedgehog reception

(2017) Laura González-Méndez et al.   eLife

Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals

(2016) Kyle M. Loh et al.   DEVELOPMENTAL CELL

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Role of cytonemes in Wnt transport

(2016) Eliana Stanganello et al.   JOURNAL OF CELL SCIENCE

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

(2016) Melissa V. Gammons et al.   MOLECULAR CELL

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs

(2016) Yasuo Yamazaki et al.   NATURE CELL BIOLOGY

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon

(2016) Nobuo Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

(2016) Emiko Mihara et al.   eLife

Afamin — A pleiotropic glycoprotein involved in various disease states

(2015) Hans Dieplinger et al.   CLINICA CHIMICA ACTA

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions

(2015) J. C. Snyder et al.   JOURNAL OF CELL SCIENCE

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

(2015) Hai Huang et al.   eLife

Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development

(2015) Robert N. Duncan et al.   PLoS One

Production of a reference transcriptome and transcriptomic database (EdwardsiellaBase) for the lined sea anemone, Edwardsiella lineata, a parasitic cnidarian

(2014) Derek J Stefanik et al.   BMC GENOMICS

Migrating cells mediate long-range WNT signaling

(2014) O. Serralbo et al.   DEVELOPMENT

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

(2014) Jia Yu et al.   DEVELOPMENTAL CELL

Disulfide Bond Requirements for Active Wnt Ligands

(2014) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo analysis of formation and endocytosis of the Wnt/ -Catenin signaling complex in zebrafish embryos

(2014) A. I. H. Hagemann et al.   JOURNAL OF CELL SCIENCE

Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm

(2014) Marta Luz et al.   PLoS One

Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless

(2014) Yung-Heng Chang et al.   PLoS One

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

(2013) Charles P. Xavier et al.   CELLULAR SIGNALLING

Morphogen transport

(2013) P. Muller et al.   DEVELOPMENT

Wnt Secretion and Gradient Formation

(2013) Gonzalo Solis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms

(2013) H. Yamamoto et al.   JOURNAL OF CELL SCIENCE

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Live imaging of active fluorophore labelled Wnt proteins

(2012) Tatjana Holzer et al.   FEBS LETTERS

Structure–Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling

(2012) David Strutt et al.   GENETICS

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Wnt/Wingless Signaling in Drosophila

(2012) S. Swarup et al.   Cold Spring Harbor Perspectives in Biology

Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation

(2011) Ralf Janssen et al.   BMC EVOLUTIONARY BIOLOGY

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos

(2011) Steffen Biechele et al.   DEVELOPMENTAL BIOLOGY

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

(2011) Bo Gao et al.   DEVELOPMENTAL CELL

p24 proteins are required for secretion of Wnt ligands

(2011) Tina Buechling et al.   EMBO REPORTS

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

(2011) J. J. Barrott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of the Rho-family small GTPases in actin regulation and motility

(2011) Désirée Spiering et al.   Cell Adhesion & Migration

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

(2010) G. S. Coombs et al.   JOURNAL OF CELL SCIENCE

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range

(2009) Y. Mii et al.   DEVELOPMENT

A study on the interactions between heparan sulfate proteoglycans and Wnt proteins

(2009) Christophe Fuerer et al.   DEVELOPMENTAL DYNAMICS

Wnt signaling pathways meet Rho GTPases

(2009) K. Schlessinger et al.   GENES & DEVELOPMENT

Heparan Sulfate 2-O-Sulfotransferase Is Required for Triglyceride-rich Lipoprotein Clearance

(2009) Kristin I. Stanford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Wnt3a is Released on Lipoprotein Particles

(2009) Sylvia Neumann et al.   TRAFFIC

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

(2008) Vladimir L Katanaev et al.   EMBO JOURNAL

Regulation of Wnt protein secretion and its role in gradient formation

(2008) Kerstin Bartscherer et al.   EMBO REPORTS

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

Rapid Activity-Dependent Modifications in Synaptic Structure and Function Require Bidirectional Wnt Signaling

(2008) Bulent Ataman et al.   NEURON

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL