4.3 Review

The colonial cnidarian Hydractinia

Journal

EVODEVO
Volume 11, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s13227-020-00151-0

Keywords

Cnidaria; Hydrozoa; Allorecognition; Regeneration; Stem cells; CRISPR

Funding

  1. NSF program Enabling Discovery through GEnomics tools-EDGE [1923259]
  2. NSF [1557339]
  3. SFI-HRB-Wellcome Biomedical Research Partnership
  4. Wellcome Trust [210722/Z/18/Z]
  5. Wellcome Trust [210722/Z/18/Z] Funding Source: Wellcome Trust
  6. Direct For Biological Sciences
  7. Division Of Integrative Organismal Systems [1923259, 1557339] Funding Source: National Science Foundation

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Hydractinia, a genus of colonial marine cnidarians, has been used as a model organism for developmental biology and comparative immunology for over a century. It was this animal where stem cells and germ cells were first studied. However, protocols for efficient genetic engineering have only recently been established by a small but interactive community of researchers. The animal grows well in the lab, spawns daily, and its relatively short life cycle allows genetic studies. The availability of genomic tools and resources opens further opportunities for research using this animal. Its accessibility to experimental manipulation, growth- and cellular-plasticity, regenerative ability, and resistance to aging and cancer place Hydractinia as an emerging model for research in many biological and environmental disciplines.

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