The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality

(2009) Xingqun Liang et al.   CIRCULATION

Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation

(2009) N. Akhtar et al.   DEVELOPMENT

Spatial Coordination of Actin Polymerization and ILK–Akt2 Activity during Endothelial Cell Migration

(2009) Yi Fan et al.   DEVELOPMENTAL CELL

α-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

(2009) Eloi Montanez et al.   EMBO JOURNAL

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

Genetic and cell biological analysis of integrin outside-in signaling

(2009) K. R. Legate et al.   GENES & DEVELOPMENT

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction

(2009) N. Kogata et al.   GENES & DEVELOPMENT

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system

(2009) Jorge A. Pereira et al.   JOURNAL OF CELL BIOLOGY

EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility

(2009) T. Yamazaki et al.   JOURNAL OF CELL SCIENCE

Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

(2009) F. Stanchi et al.   JOURNAL OF CELL SCIENCE

Integrin-linked Kinase Interactions with ELMO2 Modulate Cell Polarity

(2009) Ernest Ho et al.   MOLECULAR BIOLOGY OF THE CELL

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

(2009) Koichi Fukuda et al.   MOLECULAR CELL

Integrin-linked kinase is an adaptor with essential functions during mouse development

(2009) Anika Lange et al.   NATURE

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation

(2009) M-A Kim et al.   ONCOGENE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Pseudokinases: Functional Insights Gleaned from Structure

(2009) Alexandr P. Kornev et al.   STRUCTURE

A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

(2008) K. L. Tucker et al.   BLOOD

Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

(2008) P. C. McDonald et al.   CANCER RESEARCH

Rethinking Pseudokinases

(2008) Natarajan Kannan et al.   CELL

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

Integrin β1 Subunit Controls Mural Cell Adhesion, Spreading, and Blood Vessel Wall Stability

(2008) Sabu Abraham et al.   CIRCULATION RESEARCH

Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin–ECM adhesion complex

(2008) Ruben Postel et al.   DEVELOPMENTAL BIOLOGY

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly

(2008) Vasiliki Gkretsi et al.   HEPATOLOGY

The Structure of α-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly

(2008) Xiaoxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Adhesion-dependent Cofilin Serine 3 Phosphorylation by the Integrin-linked Kinase·c-Src Complex

(2008) Yong-Bae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization

(2008) Andrew B. Fielding et al.   JOURNAL OF CELL BIOLOGY

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

(2008) Hao-Ven Wang et al.   JOURNAL OF CELL BIOLOGY

Integrin-linked kinase - essential roles in physiology and cancer biology

(2008) P. C. McDonald et al.   JOURNAL OF CELL SCIENCE

Mapping the Integrin-Linked Kinase Interactome Using SILAC

(2008) Iveta Dobreva et al.   JOURNAL OF PROTEOME RESEARCH

Impaired Hair Follicle Morphogenesis and Polarized Keratinocyte Movement upon Conditional Inactivation of Integrin-linked Kinase in the Epidermis

(2008) Kerry-Ann Nakrieko et al.   MOLECULAR BIOLOGY OF THE CELL

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

The structural basis of integrin-linked kinase-PINCH interactions

(2008) B. P. Chiswell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

(2008) Sonja Lorenz et al.   STRUCTURE

Integrin β1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus

(2007) Keizo Kanasaki et al.   DEVELOPMENTAL BIOLOGY

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL