Sumoylation in Physiology, Pathology and Therapy

SUMOylation inhibition enhances dexamethasone sensitivity in multiple myeloma

(2022) Li Du et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease

(2022) Uri Nimrod Ramírez-Jarquín et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer

(2021) Steven P. Langston et al.   JOURNAL OF MEDICINAL CHEMISTRY

SUMO: Glue or Solvent for Phase-Separated Ribonucleoprotein Complexes and Molecular Condensates?

(2021) Jan Keiten-Schmitz et al.   Frontiers in Molecular Biosciences

Targeting SUMOylation in cancer

(2021) Li Du et al.   CURRENT OPINION IN ONCOLOGY

Therapeutic Potential of Targeting the SUMO Pathway in Cancer

(2021) Antti Kukkula et al.   Cancers

The BRCA1/BARD1 ubiquitin ligase and its substrates

(2021) Samuel R. Witus et al.   BIOCHEMICAL JOURNAL

Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts

(2020) Arda B. Celen et al.   FEBS Journal

SETDB1-Mediated Silencing of Retroelements

(2020) Kei Fukuda et al.   Viruses-Basel

SUMO and cellular adaptive mechanisms

(2020) Hong-Yeoul Ryu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

PDPK1 regulates autophagosome biogenesis by binding to PIK3C3

(2020) Boli Hu et al.   Autophagy

Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force

(2020) Aurélie Zbinden et al.   DEVELOPMENTAL CELL

SUMO promotes longevity and maintains mitochondrial homeostasis during ageing in Caenorhabditis elegans

(2020) Andrea Princz et al.   Scientific Reports

Matter over mind: Liquid phase separation and neurodegeneration

(2019) Shana Elbaum-Garfinkle   JOURNAL OF BIOLOGICAL CHEMISTRY

Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program

(2019) Mélanie Eckersley-Maslin et al.   GENES & DEVELOPMENT

DPPA2 and DPPA4 are necessary to establish a 2C‐like state in mouse embryonic stem cells

(2019) Alberto De Iaco et al.   EMBO REPORTS

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

(2019) Albert Escobedo et al.   Nature Communications

DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program

(2019) Yao-Long Yan et al.   PLOS BIOLOGY

Adult Neural Stem Cells: Born to Last

(2019) Aixa V. Morales et al.   Frontiers in Cell and Developmental Biology

A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3

(2019) Kejia Liu et al.   Autophagy

The SUMO Pathway in Hematomalignancies and Their Response to Therapies

(2019) Mathias Boulanger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dealing With Stress: A Review of Plant SUMO Proteases

(2019) Rebecca Morrell et al.   Frontiers in Plant Science

Targeting the SUMO Pathway Primes All-transRetinoic Acid–Induced Differentiation of Nonpromyelocytic Acute Myeloid Leukemias

(2018) Hayeon Baik et al.   CANCER RESEARCH

SUMOylation: re-wiring the plant nucleus during stress and development

(2018) Robert C Augustine et al.   CURRENT OPINION IN PLANT BIOLOGY

SUMO-specific proteases and isopeptidases of the SENP family at a glance

(2018) Kathrin Kunz et al.   JOURNAL OF CELL SCIENCE

PML nuclear bodies, membrane-less domains acting as ROS sensors?

(2018) Michiko Niwa-Kawakita et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RING tetramerization is required for nuclear body biogenesis and PML sumoylation

(2018) Pengran Wang et al.   Nature Communications

Site-specific characterization of endogenous SUMOylation across species and organs

(2018) Ivo A. Hendriks et al.   Nature Communications

Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency

(2018) Charles Hernandez et al.   Cell Stem Cell

Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV

(2018) Fengting Liu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ubiquitin, SUMO, and NEDD8: Key Targets of Bacterial Pathogens

(2018) David Ribet et al.   TRENDS IN CELL BIOLOGY

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States

(2018) Jack-Christophe Cossec et al.   Cell Stem Cell

SUMO proteins: Guardians of immune system

(2017) Sabrina Adorisio et al.   JOURNAL OF AUTOIMMUNITY

PML is a ROS sensor activating p53 upon oxidative stress

(2017) Michiko Niwa-Kawakita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

(2017) Xingyue He et al.   Nature Chemical Biology

Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation

(2017) Lina Qiao et al.   Oncology Letters

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

(2017) Ramesh Kumar et al.   Nature Communications

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair

(2017) Ruth M. Densham et al.   Nucleus

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

The Sumo protease Senp7 is required for proper neuronal differentiation

(2016) Francisco Juarez-Vicente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

The implication of SUMO in intrinsic and innate immunity

(2016) Zara Hannoun et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Pias1 is essential for erythroid and vascular development in the mouse embryo

(2016) Jerfiz D. Constanzo et al.   DEVELOPMENTAL BIOLOGY

Ginkgolic Acid Inhibits Invasion and Migration and TGF-β-Induced EMT of Lung Cancer Cells Through PI3K/Akt/mTOR Inactivation

(2016) Seung Ho Baek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin

(2016) Christèle Maison et al.   Nature Communications

Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

(2016) Li Du et al.   Nature Communications

PIAS1 Promotes Lymphomagenesis through MYC Upregulation

(2016) Andrea Rabellino et al.   Cell Reports

Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas

(2016) Maria V. Bogachek et al.   Stem Cell Reports

SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies

(2016) Ya-Chen Liang et al.   Scientific Reports

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

(2015) Bin Xia Yang et al.   CELL

c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4

(2015) Román González-Prieto et al.   CELL CYCLE

Mapping the SUMOylated landscape

(2015) Karolin Eifler et al.   FEBS Journal

PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

(2015) Lisa Ivanschitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

(2015) Changwon Kho et al.   Nature Communications

System-wide identification of wild-type SUMO-2 conjugation sites

(2015) Ivo A. Hendriks et al.   Nature Communications

Analysis of the SUMO2 Proteome during HSV-1 Infection

(2015) Elizabeth Sloan et al.   PLoS Pathogens

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

(2014) Z. Dassouki et al.   BLOOD

Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma

(2014) A. Hoellein et al.   BLOOD

Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity

(2014) Jie Li et al.   CANCER CELL

SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development

(2014) L. Wang et al.   EMBO REPORTS

Retinoic acid signaling in cancer: The parable of acute promyelocytic leukemia

(2014) Julien Ablain et al.   INTERNATIONAL JOURNAL OF CANCER

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

PML nuclear bodies: regulation, function and therapeutic perspectives

(2014) Umut Sahin et al.   JOURNAL OF PATHOLOGY

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

(2014) Julien Ablain et al.   NATURE MEDICINE

Uncovering global SUMOylation signaling networks in a site-specific manner

(2014) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner

(2014) Päivi Sutinen et al.   NUCLEIC ACIDS RESEARCH

SUMOylation of Myc-Family Proteins

(2014) Arianna Sabò et al.   PLoS One

SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination

(2014) Hong-Bin Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome-Wide Identification of SUMO2 Modification Sites

(2014) T. Tammsalu et al.   Science Signaling

Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

(2014) Umut Sahin et al.   Nature Communications

The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

(2014) Guillaume Bossis et al.   Cell Reports

PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation

(2014) Umut Sahin et al.   Nucleus

Control of Nuclear Activities by Substrate-Selective and Protein-Group SUMOylation

(2013) Stefan Jentsch et al.   Annual Review of Genetics

Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice

(2013) Alice Chort et al.   BRAIN

Cancer stem cells: A contentious hypothesis now moving forward

(2013) Michael L. O’Connor et al.   CANCER LETTERS

Over-Expression of Small Ubiquitin-Related Modifier-1 and Sumoylated p53 in Colon Cancer

(2013) Hongjie Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

(2013) Xing Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation

(2013) H. Neyret-Kahn et al.   GENOME RESEARCH

LIN28/LIN28B: An emerging oncogenic driver in cancer stem cells

(2013) Jianbiao Zhou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Posttranslational Modification of the Androgen Receptor in Prostate Cancer

(2013) Travis Van der Steen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sumoylation of Krüppel-like Factor 4 Inhibits Pluripotency Induction but Promotes Adipocyte Differentiation

(2013) Soroush Tahmasebi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between viruses and host sumoylation pathways

(2013) Roger D. Everett et al.   NATURE REVIEWS MICROBIOLOGY

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

(2013) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SUMO Conjugating Enzyme Ubc9 Is Required for Inducing and Maintaining Stem Cell Pluripotency

(2013) Soroush Tahmasebi et al.   STEM CELLS

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review

(2013) Sandeep K. Vishwakarma et al.   Journal of Advanced Research

Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival

(2012) Wei Yang et al.   CANCER SCIENCE

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Sumoylation in neurodegenerative diseases

(2012) Petranka Krumova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

Acute promyelocytic leukemia, arsenic, and PML bodies

(2012) Hugues de Thé et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveals Factors Regulating RNA Biology as Dynamic Targets of Stress-induced SUMOylation inArabidopsis

(2012) Marcus J. Miller et al.   MOLECULAR & CELLULAR PROTEOMICS

Extensive DNA Damage-Induced Sumoylation Contributes to Replication and Repair and Acts in Addition to the Mec1 Checkpoint

(2012) Catherine A. Cremona et al.   MOLECULAR CELL

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

How I treat adult T-cell leukemia/lymphoma

(2011) A. Bazarbachi et al.   BLOOD

Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation

(2011) Yohan Oh et al.   BRAIN RESEARCH

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin

(2011) Christèle Maison et al.   NATURE GENETICS

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Drug-Induced Degradation of Oncoproteins: An Unexpected Achilles' Heel of Cancer Cells?

(2011) Julien Ablain et al.   Cancer Discovery

SUMOylation and bacterial pathogens

(2011) David Ribet et al.   Virulence

A Viral Ubiquitin Ligase Has Substrate Preferential SUMO Targeted Ubiquitin Ligase Activity that Counteracts Intrinsic Antiviral Defence

(2011) Chris Boutell et al.   PLoS Pathogens

Ubc9 expression predicts chemoresistance in breast cancer

(2011) Shi-Feng Chen et al.   Chinese Journal of Cancer

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Role of UBC9 in the Regulation of the Adipogenic Program in 3T3-L1 Adipocytes

(2010) Angelo Cignarelli et al.   ENDOCRINOLOGY

SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis

(2010) Luyang Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multiplex SILAC Analysis of a Cellular TDP-43 Proteinopathy Model Reveals Protein Inclusions Associated with SUMOylation and Diverse Polyubiquitin Chains

(2010) Nicholas T. Seyfried et al.   MOLECULAR & CELLULAR PROTEOMICS

Site-Specific Identification of SUMO-2 Targets in Cells Reveals an Inverted SUMOylation Motif and a Hydrophobic Cluster SUMOylation Motif

(2010) Ivan Matic et al.   MOLECULAR CELL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Listeria monocytogenes impairs SUMOylation for efficient infection

(2010) David Ribet et al.   NATURE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia Inactivates the VHL Tumor Suppressor through PIASy-Mediated SUMO Modification

(2010) Qiliang Cai et al.   PLoS One

Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes

(2010) N. Elrouby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIAS proteins: pleiotropic interactors associated with SUMO

(2009) Miia M. Rytinki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Genome stability roles of SUMO-targeted ubiquitin ligases

(2009) J. Heideker et al.   DNA REPAIR

Direct Binding of CoREST1 to SUMO-2/3 Contributes to Gene-Specific Repression by the LSD1/CoREST1/HDAC Complex

(2009) Jian Ouyang et al.   MOLECULAR CELL

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Origin and function of ubiquitin-like proteins

(2009) Mark Hochstrasser   NATURE

Genetic and Proteomic Evidence for Roles of Drosophila SUMO in Cell Cycle Control, Ras Signaling, and Early Pattern Formation

(2009) Minghua Nie et al.   PLoS One

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

PIAS1 Mediates TGFβ-Induced SM α-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation

(2008) Keiko Kawai-Kowase et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels

(2008) Yu-Qian Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3

(2008) E. Evdokimov et al.   JOURNAL OF CELL SCIENCE

Sumo-1 Function Is Dispensable in Normal Mouse Development

(2008) F.-P. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism and Consequences for Paralog-Specific Sumoylation of Ubiquitin-Specific Protease 25

(2008) Erik Meulmeester et al.   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

The PTEN–PI3K pathway: of feedbacks and cross-talks

(2008) A Carracedo et al.   ONCOGENE