ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

PML nuclear bodies: regulation, function and therapeutic perspectives

(2014) Umut Sahin et al.   JOURNAL OF PATHOLOGY

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

(2014) Julien Ablain et al.   NATURE MEDICINE

How I treat adult T-cell leukemia/lymphoma

(2011) A. Bazarbachi et al.   BLOOD

The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax

(2011) K. A. Fryrear et al.   BLOOD

Molecular mechanisms of HTLV-1 infection and pathogenesis

(2011) Junichiro Yasunaga et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?

(2011) Rihab Nasr et al.   Viruses-Basel

Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome

(2010) Y. Kfoury et al.   BLOOD

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

(2010) Hiba El Hajj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

(2009) G. Kchour et al.   BLOOD

Curing APL: Differentiation or Destruction?

(2009) Scott C. Kogan   CANCER CELL

Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation

(2008) J. Arnold et al.   BLOOD

Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

(2008) Kunihiro Tsukasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE