Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease

Patterns of neuronal Rhes as a novel hallmark of tauopathies

(2021) Alexander J. Ehrenberg et al.   ACTA NEUROPATHOLOGICA

Novel Therapeutic Approach to Induce Autophagy in a Drosophila Model for Huntington’s Disease

(2020) Marta Martinez-Vicente   Cells

Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice

(2020) Qiong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease

(2020) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities

(2020) Sarah J. Tabrizi et al.   Nature Reviews Neurology

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

(2020) Valentina Fodale et al.   Scientific Reports

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Meso scale discovery-based assays for the detection of aggregated huntingtin

(2019) Wolfgang Reindl et al.   PLoS One

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension

(2019) Yufeng Yao et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The Autophagy Lysosomal Pathway and Neurodegeneration

(2019) Steven Finkbeiner   Cold Spring Harbor Perspectives in Biology

A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3

(2019) Kejia Liu et al.   Autophagy

Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1

(2019) Mar Lorente et al.   JOURNAL OF CELL SCIENCE

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates

(2019) Shamini Vijayakumaran et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy

(2019) Leora M. Fox et al.   NEURON

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

(2018) Rebecca Aron et al.   Nature Communications

Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

(2018) Bhavana Chhunchha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

(2018) Mingdong Liu et al.   Nature Communications

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

Autophagy Receptors and Neurodegenerative Diseases

(2017) Zhiqiang Deng et al.   TRENDS IN CELL BIOLOGY

mGluR5 antagonism increases autophagy and prevents disease progression in thezQ175mouse model of Huntington’s disease

(2017) Khaled S. Abd-Elrahman et al.   Science Signaling

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised HeartsNovelty and Significance

(2016) Manish K. Gupta et al.   CIRCULATION RESEARCH

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

(2016) Amber L. Southwell et al.   HUMAN MOLECULAR GENETICS

Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes

(2016) T. Zhao et al.   JOURNAL OF NEUROSCIENCE

Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice

(2016) Peter Langfelder et al.   NATURE NEUROSCIENCE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity

(2016) Mineko Terao et al.   Scientific Reports

Autophagy Constitutes a Protective Mechanism against Ethanol Toxicity in Mouse Astrocytes and Neurons

(2016) Antoni Pla et al.   PLoS One

HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?

(2015) Yan-Ning Rui et al.   Autophagy

Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington’s disease

(2015) Peter McColgan et al.   BRAIN

Selective autophagy and Huntingtin: learning from disease

(2015) Ana Maria Cuervo et al.   CELL CYCLE

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Autophagy in Huntington disease and huntingtin in autophagy

(2015) Dale D.O. Martin et al.   TRENDS IN NEUROSCIENCES

Cytoplasmic sphingosine-1-phosphate pathway modulates neuronal autophagy

(2015) Jose Felix Moruno Manchon et al.   Scientific Reports

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

(2015) Nikisha Carty et al.   PLoS One

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

(2014) G. A. Smith et al.   HUMAN MOLECULAR GENETICS

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Characterization of Neurophysiological and Behavioral Changes, MRI Brain Volumetry and 1H MRS in zQ175 Knock-In Mouse Model of Huntington's Disease

(2012) Taneli Heikkinen et al.   PLoS One

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

(2011) Qiuli Liang et al.   Molecular Neurodegeneration

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate

(2009) Isao Fukuda et al.   CHEMISTRY & BIOLOGY

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION