SUMO-specific proteases and isopeptidases of the SENP family at a glance

Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes

(2017) Arnab Nayak et al.   Epigenetics & Chromatin

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

(2017) Ye Cui et al.   PLoS Pathogens

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian Pre-ribosome Remodeling

(2016) Nithya Raman et al.   MOLECULAR CELL

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

USP7 is a SUMO deubiquitinase essential for DNA replication

(2016) Emilio Lecona et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMO Signaling by Hypoxic Inactivation of SUMO-Specific Isopeptidases

(2016) Kathrin Kunz et al.   Cell Reports

Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4)

(2015) Ivo A. Hendriks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function

(2015) Kyung-Sun Heo et al.   JOURNAL OF CLINICAL INVESTIGATION

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells

(2015) Mourad Ferdaoussi et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

(2015) Ian Gibbs-Seymour et al.   MOLECULAR CELL

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

(2015) Lan Shao et al.   Nature Communications

The SENP7 SUMO-Protease Presents a Module of Two HP1 Interaction Motifs that Locks HP1 Protein at Pericentric Heterochromatin

(2015) Kelly Romeo et al.   Cell Reports

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

(2015) Jessica R. Gooding et al.   Cell Reports

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

(2015) Hengrui Zhu et al.   Cell Reports

Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection

(2014) Kevin Maringer et al.   CYTOKINE & GROWTH FACTOR REVIEWS

mTOR Signaling Regulates Nucleolar Targeting of the SUMO-Specific Isopeptidase SENP3

(2014) N. Raman et al.   MOLECULAR AND CELLULAR BIOLOGY

The SUMO-Specific Isopeptidase SENP3 Regulates MLL1/MLL2 Methyltransferase Complexes and Controls Osteogenic Differentiation

(2014) Arnab Nayak et al.   MOLECULAR CELL

Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death

(2014) Yitao Qi et al.   NEURON

Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration

(2014) Jiang Fu et al.   PLoS Genetics

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Control of Nuclear Activities by Substrate-Selective and Protein-Group SUMOylation

(2013) Stefan Jentsch et al.   Annual Review of Genetics

SUMO-targeted ubiquitin ligases

(2013) Annie M. Sriramachandran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The SUMO system: a master organizer of nuclear protein assemblies

(2013) Nithya Raman et al.   CHROMOSOMA

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

(2013) Alexander J Garvin et al.   EMBO REPORTS

SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis

(2013) Caelin Cubeñas-Potts et al.   MOLECULAR BIOLOGY OF THE CELL

Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6

(2013) Xing Liu et al.   PLoS Pathogens

Heat shock induces a massive but differential inactivation of SUMO-specific proteases

(2012) Manuel P. Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin

(2012) Christèle Maison et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition

(2012) T. Bawa-Khalfe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage

(2012) C. M. Guzzo et al.   Science Signaling

SUMO routes ribosome maturation

(2012) Elisabeth Finkbeiner et al.   Nucleus

Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2

(2012) Kin-Hoe Chow et al.   Nucleus

The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex

(2011) Elisabeth Finkbeiner et al.   EMBO JOURNAL

Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7

(2011) Kamela O. Alegre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex

(2011) Jacqueline Goeres et al.   MOLECULAR BIOLOGY OF THE CELL

LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis

(2011) Christopher D. Castle et al.   MOLECULAR BIOLOGY OF THE CELL

NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

(2011) Moon Hee Lee et al.   MOLECULAR CELL

Coronin 2A mediates actin-dependent de-repression of inflammatory response genes

(2011) Wendy Huang et al.   NATURE

Distribution and paralogue specificity of mammalian deSUMOylating enzymes

(2010) Nagamalleswari Kolli et al.   BIOCHEMICAL JOURNAL

SUMO chains: polymeric signals: Figure 1

(2010) Alfred C.O. Vertegaal   BIOCHEMICAL SOCIETY TRANSACTIONS

The fate of metaphase kinetochores is weighed in the balance of SUMOylation during S phase

(2010) Debaditya Mukhopadhyay et al.   CELL CYCLE

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

(2010) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

(2010) Neil Hattersley et al.   MOLECULAR BIOLOGY OF THE CELL

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex

(2010) Hong Dou et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of SENP7, a SUMO-2/3-specific isopeptidase

(2009) Lin Nan Shen et al.   BIOCHEMICAL JOURNAL

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis

(2009) Rodolfo Zunino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

An additional role for SUMO in ubiquitin-mediated proteolysis

(2009) Marie-Claude Geoffroy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing

(2008) Markus Haindl et al.   EMBO REPORTS

Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7

(2008) Christopher D. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases

(2008) Chawon Yun et al.   JOURNAL OF CELL BIOLOGY

RanBP2 and SENP3 Function in a Mitotic SUMO2/3 Conjugation-Deconjugation Cycle on Borealin

(2008) Ulf R. Klein et al.   MOLECULAR BIOLOGY OF THE CELL

SUMO-2/3 Modification and Binding Regulate the Association of CENP-E with Kinetochores and Progression through Mitosis

(2008) Xiang-Dong Zhang et al.   MOLECULAR CELL

The Fast-Growing Business of SUMO Chains

(2008) Helle D. Ulrich   MOLECULAR CELL

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation

(2007) Zheng Xu et al.   FASEB JOURNAL