PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation

A requiem to the nuclear matrix: from a controversial concept to 3D organization of the nucleus

(2014) S. V. Razin et al.   CHROMOSOMA

Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

(2014) Umut Sahin et al.   JOURNAL OF CELL BIOLOGY

PML, SUMO, and RNF4: Guardians of Nuclear Protein Quality

(2014) Anne Gärtner et al.   MOLECULAR CELL

A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration

(2014) Lili Guo et al.   MOLECULAR CELL

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

(2014) Julien Ablain et al.   NATURE MEDICINE

Proteome-Wide Identification of SUMO2 Modification Sites

(2014) T. Tammsalu et al.   Science Signaling

Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication

(2014) Umut Sahin et al.   Nature Communications

A Dialog on the First 20 Years of PML Research and the Next 20 Ahead

(2014) Rosa Bernardi et al.   Frontiers in Oncology

Decoding the SUMO signal

(2013) Ronald T. Hay   BIOCHEMICAL SOCIETY TRANSACTIONS

Interferon beta induces clearance of mutant ataxin 7 and improves locomotion in SCA7 knock-in mice

(2013) Alice Chort et al.   BRAIN

SUMOylation of p53 mediates interferon activities

(2013) Laura Marcos-Villar et al.   CELL CYCLE

SUMO: A Multifaceted Modifier of Chromatin Structure and Function

(2013) Caelin Cubeñas-Potts et al.   DEVELOPMENTAL CELL

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

(2013) Guilherme Augusto dos Santos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between viruses and host sumoylation pathways

(2013) Roger D. Everett et al.   NATURE REVIEWS MICROBIOLOGY

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Strategies to Direct Therapeutic Targeting of PML to Treat Cancers

(2013) Kamil Wolyniec et al.   Frontiers in Oncology

PML in the Brain: From Development to Degeneration

(2013) Erica Korb et al.   Frontiers in Oncology

Is PML a Tumor Suppressor?

(2013) Massimiliano Mazza et al.   Frontiers in Oncology

Crowding Effects on the Formation and Maintenance of Nuclear Bodies: Insights from Molecular-Dynamics Simulations of Simple Spherical Model Particles

(2012) Eun Jin Cho et al.   BIOPHYSICAL JOURNAL

Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma

(2012) Toshiyuki Okazaki et al.   CANCER LETTERS

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

Sumoylation in neurodegenerative diseases

(2012) Petranka Krumova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear bodies: multifunctional companions of the genome

(2012) Miroslav Dundr   CURRENT OPINION IN CELL BIOLOGY

An Acetylation Switch Regulates SUMO-Dependent Protein Interaction Networks

(2012) Rebecca Ullmann et al.   MOLECULAR CELL

Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity

(2012) Maria V. Chiantore et al.   PLoS One

PML body meets telomere

(2012) Inn Chung et al.   Nucleus

Regulation of the tumor suppressor PML by sequential post-translational modifications

(2012) M. Lienhard Schmitz et al.   Frontiers in Oncology

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

SUMO in the mammalian response to DNA damage: Figure 1

(2010) Joanna R. Morris   BIOCHEMICAL SOCIETY TRANSACTIONS

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

Pathogen-Mediated Posttranslational Modifications: A Re-emerging Field

(2010) David Ribet et al.   CELL

Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

(2010) Sona Hubackova et al.   CELL CYCLE

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53

(2010) Ki Sa Sung et al.   EXPERIMENTAL CELL RESEARCH

Three-dimensional organization of promyelocytic leukemia nuclear bodies

(2010) M. Lang et al.   JOURNAL OF CELL SCIENCE

PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication

(2010) D. Cuchet et al.   JOURNAL OF CELL SCIENCE

Single-Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia: Long-Term Follow-Up Data

(2010) Vikram Mathews et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

(2010) Hiba El Hajj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Role of PML in the Nervous System

(2010) Paolo Salomoni et al.   MOLECULAR NEUROBIOLOGY

Listeria monocytogenes impairs SUMOylation for efficient infection

(2010) David Ribet et al.   NATURE

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUMO E3 ligase activity of TRIM proteins

(2010) Y Chu et al.   ONCOGENE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

SUMO Proteases: Redox Regulation and Biological Consequences

(2009) Zheng Xu et al.   ANTIOXIDANTS & REDOX SIGNALING

Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)

(2009) G. Kchour et al.   BLOOD

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

(2009) Alexandre Janer et al.   HUMAN MOLECULAR GENETICS

Pml and TAp73 interacting at nuclear body mediate imatinib-induced p53-independent apoptosis of chronic myeloid leukemia cells

(2009) Jin-Hwang Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Components of Nuclear Domain 10 Bodies Regulate Varicella-Zoster Virus Replication

(2009) C. A. Kyratsous et al.   JOURNAL OF VIROLOGY

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

PML NBs (ND10) and Daxx: from nuclear structure to protein function

(2008) Cory et al.   Frontiers in Bioscience-Landmark

Acetylation of PML Is Involved in Histone Deacetylase Inhibitor-mediated Apoptosis

(2008) Fumihiko Hayakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of component exchange at PML nuclear bodies

(2008) S. Weidtkamp-Peters et al.   JOURNAL OF CELL SCIENCE

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

(2008) E Gresko et al.   ONCOGENE