Extracellular vesicles: emerging tools as therapeutic agent carriers

Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions

(2021) Jun-Yong Wu et al.   DRUG DELIVERY

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

(2021) Rebekah Omarkhail Elliott et al.   Pharmaceutics

Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune Responses

(2021) J. Timothy Prior et al.   Pharmaceutics

The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

(2021) Dongdong Zheng et al.   Frontiers in Cell and Developmental Biology

Biopolymer-liposome hybrid systems for controlled delivery of bioactive compounds: Recent advances

(2021) Chen Tan et al.   BIOTECHNOLOGY ADVANCES

Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

(2021) GyeungYun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Recent Progress on Exosomes in RNA Virus Infection

(2021) Liying Zhang et al.   Viruses-Basel

Outer Membrane Vesicle Induction and Isolation for Vaccine Development

(2021) Melanie D. Balhuizen et al.   Frontiers in Microbiology

Outer Membrane Vesicles of Gram-Negative Bacteria: An Outlook on Biogenesis

(2021) Eric Daniel Avila-Calderón et al.   Frontiers in Microbiology

Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

(2021) Sarah M. Baker et al.   npj Vaccines

Exosome-Based Delivery of Natural Products in Cancer Therapy

(2021) Hang Song et al.   Frontiers in Cell and Developmental Biology

The exosome journey: from biogenesis to uptake and intracellular signalling

(2021) Sonam Gurung et al.   Cell Communication and Signaling

Fight bacteria with bacteria: Bacterial membrane vesicles as vaccines and delivery nanocarriers against bacterial infections

(2021) Yingying Gan et al.   Nanomedicine-Nanotechnology Biology and Medicine

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

(2021) Keman Cheng et al.   Nature Communications

Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies

(2021) Yulian Wang et al.   Advanced Science

Mesenchymal stromal exosome–functionalized scaffolds induce innate and adaptive immunomodulatory responses toward tissue repair

(2021) Ni Su et al.   Science Advances

Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing

(2021) Xingang Yao et al.   Journal of Extracellular Vesicles

Exosomal Non-coding RNAs-Mediated Crosstalk in the Tumor Microenvironment

(2021) Qi Chen et al.   Frontiers in Cell and Developmental Biology

Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases

(2021) Margarida Beatriz et al.   Frontiers in Cell and Developmental Biology

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction

(2021) Jialu Yao et al.   ACS Nano

Extracellular vesicles in atherothrombosis and cardiovascular disease: Friends and foes

(2021) Oriol Giró et al.   ATHEROSCLEROSIS

Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison

(2021) Jun-Yong Wu et al.   JOURNAL OF CONTROLLED RELEASE

Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9

(2021) Mathilde Mathieu et al.   Nature Communications

Covid-19: Delta variant doubles risk of hospital admission compared with alpha variant, study shows

(2021) Jacqui Wise   BMJ-British Medical Journal

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

(2021) Mangesh D. Hade et al.   Cells

Development of a novel RNAi therapy: Engineered miR-31 exosomes promoted the healing of diabetic wounds

(2021) Jinghuan Huang et al.   Bioactive Materials

Proteomic dissection of large extracellular vesicle surfaceome unravels interactive surface platform

(2021) Alin Rai et al.   Journal of Extracellular Vesicles

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion

(2020) Lu Zhang et al.   Stem Cell Research & Therapy

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

(2020) Gaofeng Liang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Delivery strategies for macromolecular drugs in cancer therapy

(2020) Qin Guo et al.   Acta Pharmaceutica Sinica B

Phenotypic analysis of extracellular vesicles: a review on the applications of fluorescence

(2020) Maria S. Panagopoulou et al.   Journal of Extracellular Vesicles

Modified bacterial outer membrane vesicles induce autoantibodies for tumor therapy

(2020) Weiwei Huang et al.   Acta Biomaterialia

Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease

(2020) Min Guo et al.   BRAIN

Exosomal miRNAs in tumor microenvironment

(2020) Shiming Tan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Visualization of exosomes from mesenchymal stem cells in vivo by magnetic resonance imaging

(2020) Tianqi Liu et al.   MAGNETIC RESONANCE IMAGING

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

(2020) Vikram Sengupta et al.   STEM CELLS AND DEVELOPMENT

Recent Advances in CRISPR/Cas9 Delivery Strategies

(2020) Bon Ham Yip   Biomolecules

Extracellular vesicles: new targets for vaccines against helminth parasites

(2020) Claire Drurey et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Bacterial outer membrane vesicles as a platform for biomedical applications: An update

(2020) Min Li et al.   JOURNAL OF CONTROLLED RELEASE

Next-generation vaccine platforms for COVID-19

(2020) Debby van Riel et al.   NATURE MATERIALS

Technologies and Standardization in Research on Extracellular Vesicles

(2020) Srujan Gandham et al.   TRENDS IN BIOTECHNOLOGY

Diabetic Nephropathy: Perspective on Extracellular Vesicles

(2020) Yanfang Lu et al.   Frontiers in Immunology

Development of New Strategies Using Extracellular Vesicles Loaded with Exogenous Nucleic Acid

(2020) Nicola Salvatore Orefice   Pharmaceutics

Generation of Small RNA-Modulated Exosome Mimetics for Bone Regeneration

(2020) Jiabing Fan et al.   ACS Nano

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

(2020) Fatemeh Mehryab et al.   Acta Biomaterialia

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

(2020) Yi Zhang et al.   International Journal of Nanomedicine

Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment

(2020) Lizhou Xu et al.   BIOMATERIALS

The role of exosomes in liquid biopsy for cancer diagnosis and prognosis prediction

(2020) Shiyu Li et al.   INTERNATIONAL JOURNAL OF CANCER

Roles of Exosomes in Ocular Diseases

(2020) Jia Liu et al.   International Journal of Nanomedicine

Dexosomes as a cell-free vaccine for cancer immunotherapy

(2020) Sepideh Nikfarjam et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Exosomes in Parkinson disease

(2020) Jennifer R. Pinnell et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway

(2020) Xia Wu et al.   Annals of Translational Medicine

Non-viral COVID-19 vaccine delivery systems

(2020) Kyung Soo Park et al.   ADVANCED DRUG DELIVERY REVIEWS

Tumor extracellular vesicles loaded with exogenous Let-7i and miR-142 can modulate both immune response and tumor microenvironment to initiate a powerful anti-tumor response

(2020) Adeleh Taghi Khani et al.   CANCER LETTERS

Prospective Therapeutic Applications of Platelet Extracellular Vesicles

(2020) Jancy Johnson et al.   TRENDS IN BIOTECHNOLOGY

Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine

(2019) Ting Zhao et al.   Current Stem Cell Research & Therapy

Adeno-associated Virus (AAV) versus Immune Response

(2019) Joseph Rabinowitz et al.   Viruses-Basel

Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

(2019) Irene Li et al.   Molecular Cancer

Exosomes in cancer development, metastasis, and immunity

(2019) Lin Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

An Exosomal Urinary miRNA Signature for Early Diagnosis of Renal Fibrosis in Lupus Nephritis

(2019) Solé et al.   Cells

Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV

(2019) Mahmoud M. Shehata et al.   Vaccines

Mapping Subpopulations of Cancer Cell-Derived Extracellular Vesicles and Particles by Nano-Flow Cytometry

(2019) Dongsic Choi et al.   ACS Nano

Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

(2019) Min Wang et al.   ACS Nano

Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy

(2019) Yingxuan Zhang et al.   Cancers

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

PAK4 pathway as a potential therapeutic target in pancreatic cancer

(2018) Kiruthikah Thillai et al.   Future Oncology

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies

(2018) Taylor C. Stevenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas9 for cancer research and therapy

(2018) Tianzuo Zhan et al.   SEMINARS IN CANCER BIOLOGY

Outer Membrane Vesicles from Neisseria Meningitidis (Proteossome) Used for Nanostructured Zika Virus Vaccine Production

(2018) Paula Martins et al.   Scientific Reports

Exosome Theranostics: Biology and Translational Medicine

(2018) Chuanjiang He et al.   Theranostics

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

(2018) Eduard Willms et al.   Frontiers in Immunology

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Mesenchymal Stem Cell Derived Exosomes in Cancer Progression, Metastasis and Drug Delivery: A Comprehensive Review

(2018) Jingyi Zhou et al.   Journal of Cancer

Natural Killer-derived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms.

(2018) Paolo Neviani et al.   CANCER RESEARCH

Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes

(2018) Mohammad N. Oskouie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Characterisation of particles in solution – a perspective on light scattering and comparative technologies

(2018) Ciarán Manus Maguire et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

(2017) Mauro Cataldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection

(2017) Hannah C. Watkins et al.   MOLECULAR THERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

(2017) Liya Zhu et al.   Theranostics

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine

(2017) Rebekah M. Samsonraj et al.   Stem Cells Translational Medicine

Investigation of Endocytic Pathways for the Internalization of Exosome-Associated Oligomeric Alpha-Synuclein

(2017) Marion Delenclos et al.   Frontiers in Neuroscience

Exosomes: A Novel Strategy for Treatment and Prevention of Diseases

(2017) Jiaqi Wang et al.   Frontiers in Pharmacology

CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells

(2017) Eun Ji Kim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling

(2016) Yejing Weng et al.   ANALYST

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

(2016) Masaki Morishita et al.   BIOMATERIALS

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG

(2016) David Skurnik et al.   Expert Review of Vaccines

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Charge-based precipitation of extracellular vesicles

(2016) Maria Chiara Deregibus et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mechanism of hard-nanomaterial clearance by the liver

(2016) Kim M. Tsoi et al.   NATURE MATERIALS

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling

(2016) Li-Fang He et al.   Oncotarget

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

(2016) Ana Gámez-Valero et al.   Scientific Reports

HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion

(2015) Emily N. Pawlak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors

(2015) G. Pironti et al.   CIRCULATION

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity

(2015) René H. M. Raeven et al.   JOURNAL OF PROTEOME RESEARCH

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

(2015) Natasa Zarovni et al.   METHODS

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

(2015) Douglas D. Taylor et al.   METHODS

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect

(2015) Tzu-Chun Chen et al.   PLoS Pathogens

Nanoparticle separation with a miniaturized asymmetrical flow field-flow fractionation cartridge

(2015) David Müller et al.   Frontiers in Chemistry

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Isolation of biologically-active exosomes from human plasma

(2014) Laurent Muller et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

Dendritic-Cell-Based Therapeutic Cancer Vaccines

(2013) Karolina Palucka et al.   IMMUNITY

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles

(2013) Zongxing Wang et al.   LAB ON A CHIP

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

(2012) Ronne Wee Yeh Yeo et al.   ADVANCED DRUG DELIVERY REVIEWS

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Progress in understanding adjuvant immunotoxicity mechanisms

(2011) Alexander Batista-Duharte et al.   TOXICOLOGY LETTERS

Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential

(2010) David Escors et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Saponins as cytotoxic agents: a review

(2010) Irma Podolak et al.   PHYTOCHEMISTRY REVIEWS

Human tumor virus utilizes exosomes for intercellular communication

(2010) D. G. Meckes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocytosisviacaveolae: alternative pathway with distinct cellular compartments to avoid lysosomal degradation?

(2009) Anna L. Kiss et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Properties and clinical performance of vaccines containing outer membrane vesicles from Neisseria meningitidis

(2009) Johan Holst et al.   VACCINE

Preparation of bacterial polysaccharide–protein conjugates: Analytical and manufacturing challenges

(2009) Carl E. Frasch   VACCINE