The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG

Influenza Vaccines: Challenges and Solutions

(2015) Katherine Houser et al.   Cell Host & Microbe

Fc receptors in antibody-dependent enhancement of viral infections

(2015) Adam Taylor et al.   IMMUNOLOGICAL REVIEWS

Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of theBacillus subtilisBiofilm Matrix

(2015) Damien Roux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A randomized phase I study of the safety and immunogenicity of three ascending dose levels of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults

(2015) Michael Nissen et al.   VACCINE

Enzymatic modifications of exopolysaccharides enhance bacterial persistence

(2015) Gregory B. Whitfield et al.   Frontiers in Microbiology

An Outpatient, Ambulant-Design, Controlled Human Infection Model Using Escalating Doses of Salmonella Typhi Challenge Delivered in Sodium Bicarbonate Solution

(2014) Claire S. Waddington et al.   CLINICAL INFECTIOUS DISEASES

Structural Basis for the De-N-acetylation of Poly-β-1,6-N-acetyl-d-glucosamine in Gram-positive Bacteria

(2014) Dustin J. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of pgaC in Klebsiella pneumoniae virulence and biofilm formation

(2014) Kuang-Ming Chen et al.   MICROBIAL PATHOGENESIS

Modification and periplasmic translocation of the biofilm exopolysaccharide poly- -1,6-N-acetyl-D-glucosamine

(2014) D. J. Little et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Poly-N-Acetylglucosamine-Shiga Toxin Broad-Spectrum Conjugate Vaccine for Shiga Toxin-Producing Escherichia coli

(2014) X. Lu et al.   mBio

Protein Antigens Increase the Protective Efficacy of a Capsule-Based Vaccine against Staphylococcus aureus in a Rat Model of Osteomyelitis

(2013) Santiago M. Lattar et al.   INFECTION AND IMMUNITY

Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection

(2013) Matthew B. Laurens et al.   PLoS One

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

(2013) C. Cywes-Bentley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Detection of Fitness Genes in Uropathogenic Escherichia coli during Systemic Infection

(2013) Sargurunathan Subashchandrabose et al.   PLoS Pathogens

Natural Antibodies in Normal Human Serum Inhibit Staphylococcus aureus Capsular Polysaccharide Vaccine Efficacy

(2012) David Skurnik et al.   CLINICAL INFECTIOUS DISEASES

Human microbial challenge: the ultimate animal model

(2012) Andrew J Pollard et al.   LANCET INFECTIOUS DISEASES

Opsonic and Protective Properties of Antibodies Raised to Conjugate Vaccines Targeting Six Staphylococcus aureus Antigens

(2012) Clarissa Pozzi et al.   PLoS One

Poly-N-Acetylglucosamine Expression by Wild-Type Yersinia pestis Is Maximal at Mammalian, Not Flea, Temperatures

(2012) P. Yoong et al.   mBio

NMR and conformational studies of linear and cyclic oligo-(1→6)-β-d-glucosamines

(2011) Alexey A. Grachev et al.   CARBOHYDRATE RESEARCH

Progress Toward a Staphylococcus aureus Vaccine

(2011) R. S. Daum et al.   CLINICAL INFECTIOUS DISEASES

Poly-N-Acetyl-β-(1-6)-Glucosamine Is a Target for Protective Immunity against Acinetobacter baumannii Infections

(2011) Leticia V. Bentancor et al.   INFECTION AND IMMUNITY

A Haemophilus ducreyi CpxR Deletion Mutant Is Virulent in Human Volunteers

(2011) Maria Labandeira-Rey et al.   JOURNAL OF INFECTIOUS DISEASES

Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC

(2011) Marcia M. Hobbs et al.   Frontiers in Microbiology

Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice

(2010) David Skurnik et al.   JOURNAL OF CLINICAL INVESTIGATION

Paths reunited: Initiation of the classical and lectin pathways of complement activation

(2009) Russell Wallis et al.   IMMUNOBIOLOGY

Synthetic  -(1->6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens

(2009) M. L. Gening et al.   INFECTION AND IMMUNITY

The pgaABCD Locus of Acinetobacter baumannii Encodes the Production of Poly- -1-6-N-Acetylglucosamine, Which Is Critical for Biofilm Formation

(2009) A. H. K. Choi et al.   JOURNAL OF BACTERIOLOGY

The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria

(2009) Patrice Nordmann et al.   LANCET INFECTIOUS DISEASES

Association between MucoidPseudomonasInfection and Bronchiectasis in Children with Cystic Fibrosis

(2009) Philip M. Farrell et al.   RADIOLOGY

Protection from Staphylococcus aureus mastitis associated with poly-N-acetyl β-1,6 glucosamine specific antibody production using biofilm-embedded bacteria

(2009) M.M. Pérez et al.   VACCINE

Insights into Yersinia pestis biofilm development: topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production

(2008) Alexander G. Bobrov et al.   ENVIRONMENTAL MICROBIOLOGY

Role of structural variations of polysaccharide antigens in the pathogenicity of Gram-negative bacteria

(2007) M. Lukáčová et al.   CLINICAL MICROBIOLOGY AND INFECTION