Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes

Splenic Enlargement and Bone Marrow Hyperplasia in Patients Receiving Trastuzumab-Emtansine for Metastatic Breast Cancer

(2017) Michael Kosmin et al.   Targeted Oncology

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor

(2016) Rong Deng et al.   mAbs

Biomechanics of red blood cells in human spleen and consequences for physiology and disease

(2016) Igor V. Pivkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Applications of Extracellular Vesicles: Clinical Promise and Open Questions

(2015) Bence György et al.   Annual Review of Pharmacology and Toxicology

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human spleen

(2015) Satoshi KUSUMI et al.   BIOMEDICAL RESEARCH-TOKYO

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

(2015) L. Guo et al.   BLOOD

Human spleen microanatomy: why mice do not suffice

(2015) Birte S. Steiniger   IMMUNOLOGY

Emergence of long-lived autoreactive plasma cells in the spleen of primary warm auto-immune hemolytic anemia patients treated with rituximab

(2015) Matthieu Mahévas et al.   JOURNAL OF AUTOIMMUNITY

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting FcRn for the modulation of antibody dynamics

(2015) E. Sally Ward et al.   MOLECULAR IMMUNOLOGY

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance

(2015) Lang Rao et al.   Small

111In-cetuximab as a diagnostic agent by accessible epidermal growth factor (EGF) receptor targeting in human metastatic colorectal carcinoma

(2015) Ying-Hsia Shih et al.   Oncotarget

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

(2015) Do Won Hwang et al.   Scientific Reports

Zwitterionic Poly(carboxybetaine)-based Cationic Liposomes for Effective Delivery of Small Interfering RNA Therapeutics without Accelerated Blood Clearance Phenomenon

(2015) Yan Li et al.   Theranostics

64Cu-DOTA-trastuzumab PET imaging and HER2 specificity of brain metastases in HER2-positive breast cancer patients

(2015) Hiroaki Kurihara et al.   EJNMMI Research

Cellular Responses and Tissue Depots for Nanoformulated Antiretroviral Therapy

(2015) Andrea L. Martinez-Skinner et al.   PLoS One

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Modified pullulan nanoparticles for oral delivery of lopinavir: Formulation and pharmacokinetic evaluation

(2014) Punna Rao Ravi et al.   CARBOHYDRATE POLYMERS

Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin

(2014) Jantana Yahuafai et al.   JOURNAL OF CONTROLLED RELEASE

ImmunoPET and biodistribution with human epidermal growth factor receptor 3 targeting antibody89Zr-RG7116

(2014) Anton GT Terwisscha van Scheltinga et al.   mAbs

Quantitative cumulative biodistribution of antibodies in mice

(2014) Victor Yip et al.   mAbs

Hydrophobic Gentamicin-Loaded Nanoparticles Are Effective against Brucella melitensis Infection in Mice

(2013) Edurne Imbuluzqueta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ex-Vivo/in-Vitro Anti-polyethylene Glycol (PEG) Immunoglobulin M Production from Murine Splenic B Cells Stimulated by PEGylated Liposome

(2013) Amr Selim Abu Lila et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

Mannose-conjugated chitosan nanoparticles loaded with rifampicin for the treatment of visceral leishmaniasis

(2013) Pramila Chaubey et al.   CARBOHYDRATE POLYMERS

Synthesis, characterization and targeting potential of zidovudine loaded sialic acid conjugated-mannosylated poly(propyleneimine) dendrimers

(2013) Virendra Gajbhiye et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles

(2013) Mark J. Ernsting et al.   JOURNAL OF CONTROLLED RELEASE

The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage

(2013) Amr S. Abu Lila et al.   JOURNAL OF CONTROLLED RELEASE

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

(2013) Kirsten Achilles Poon et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

(2012) C. Andrew Boswell et al.   AAPS Journal

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia

(2012) V. L. Patel et al.   BLOOD

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

The future of antibodies as cancer drugs

(2012) Janice M. Reichert et al.   DRUG DISCOVERY TODAY

Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon

(2012) Taro Shimizu et al.   IMMUNOBIOLOGY

Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs

(2012) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application

(2012) Ai Nagao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Biodistribution of 212Pb conjugated trastuzumab in mice

(2012) N. R. Schneider et al.   JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization

(2012) Jason Baik et al.   PLoS One

Recent advances in stealth coating of nanoparticle drug delivery systems

(2012) Zohreh Amoozgar et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Normal Organ Weights in Men

(2011) D. Kimberley Molina et al.   AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY

Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective

(2011) S.M. Moghimi et al.   Annual Review of Pharmacology and Toxicology

Immunologic effects of rituximab on the human spleen in immune thrombocytopenia

(2011) S. Audia et al.   BLOOD

Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies

(2011) A. Vossenkämper et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Repeated injections of PEGylated liposomal topotecan induces accelerated blood clearance phenomenon in rats

(2011) Yanling Ma et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Drug transporter expression in human macrophages

(2011) Amélie Moreau et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

6-mercaptopurine transport in human lymphocytes: Correlation with drug-induced cytotoxicity

(2011) Laurie S. CONKLIN et al.   Journal of Digestive Diseases

The Open Microcirculation in Human Spleens

(2011) Birte Steiniger et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

99mTc-labeled Rituximab for Imaging B Lymphocyte Infiltration in Inflammatory Autoimmune Disease Patients

(2011) G. Malviya et al.   MOLECULAR IMAGING AND BIOLOGY

Spleen: A new role for an old player?

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Microvascular fluid exchange and the revised Starling principle

(2010) J. Rodney Levick et al.   CARDIOVASCULAR RESEARCH

Pharmacokinetics and tissue distribution studies of orally administered nanoparticles encapsulated ethionamide used as potential drug delivery system in management of multi-drug resistant tuberculosis

(2010) Gaurav Kumar et al.   DRUG DELIVERY

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes

(2010) Hiroyuki Koide et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Access to the Spleen Microenvironment through Lymph Shows Local Cytokine Production, Increased Cell Flux, and Altered Signaling of Immune Cells during Lipopolysaccharide-Induced Acute Inflammation

(2010) E. Semaeva et al.   JOURNAL OF IMMUNOLOGY

Targeting HER2

(2010) Diane E. Milenic et al.   mAbs

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Understanding and overcoming major barriers in cancer nanomedicine

(2010) Shuming Nie   Nanomedicine

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

(2010) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of Splenic Marginal Zone Lymphoma: Splenectomy Versus Rituximab

(2010) Michael Bennett et al.   SEMINARS IN HEMATOLOGY

CD20 as a Target for Therapeutic Type I and II Monoclonal Antibodies

(2010) Stephen A. Beers et al.   SEMINARS IN HEMATOLOGY

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Biodistribution Mechanisms of Therapeutic Monoclonal Antibodies in Health and Disease

(2009) Mohammad Tabrizi et al.   AAPS Journal

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Translational Mini-Review Series on B Cell-Directed Therapies: The pathogenic role of B cells in autoantibody-associated autoimmune diseases - lessons from B cell-depletion therapy

(2009) M. J. Leandro et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

TargetingBrucella melitensiswith polymeric nanoparticles containing streptomycin and doxycycline

(2009) Mohamed N. Seleem et al.   FEMS MICROBIOLOGY LETTERS

Rituximab-Induced Changes in Hematolymphoid Tissues Found at Autopsy

(2008) Adina M. Cioc et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study

(2008) B. Godeau et al.   BLOOD

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Novel chemotherapy for tuberculosis: chemotherapeutic potential of econazole- and moxifloxacin-loaded PLG nanoparticles

(2008) Zahoor Ahmad et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antileishmanial activity of nano-amphotericin B deoxycholate

(2008) K. D. Manandhar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antileishmanial activity, pharmacokinetics and tissue distribution studies of mannose-grafted amphotericin B lipid nanospheres

(2008) Prabhakar Reddy Veerareddy et al.   JOURNAL OF DRUG TARGETING

B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity☆

(2008) Krisztián Papp et al.   MOLECULAR IMMUNOLOGY

Impact of low-dose rituximab on splenic B cells in ABO-incompatible renal transplant recipients

(2008) Daisuke Toki et al.   TRANSPLANT INTERNATIONAL