Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

(2020) Max Tschuschke et al.   Journal of Clinical Medicine

Isolation and analysis of extracellular vesicles in a Morpho butterfly wing-integrated microvortex biochip

(2020) Shanying Han et al.   BIOSENSORS & BIOELECTRONICS

GelMA combined with sustained release of HUVECs derived exosomes for promoting cutaneous wound healing and facilitating skin regeneration

(2020) Danyang Zhao et al.   JOURNAL OF MOLECULAR HISTOLOGY

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

(2020) Dongping Li et al.   Journal of Neuroinflammation

Exosomes derived from endoplasmic reticulum‑stressed liver cancer cells enhance the expression of cytokines in macrophages via the STAT3 signaling pathway

(2020) Chengqun He et al.   Oncology Letters

Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis

(2019) Rajashekhar Kanchanapally et al.   International Journal of Nanomedicine

Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

(2019) Qingwei Zhu et al.   Advanced Science

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

(2019) Guang Yang et al.   ACS Nano

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Explicating Exosomes: Reclassifying the Rising Stars of Intercellular Communication

(2019) Stefano Pluchino et al.   CELL

Reassessment of Exosome Composition

(2019) Dennis K. Jeppesen et al.   CELL

Cre-Reporter Mouse Model to Determine Exosome Communication and Function during Pregnancy

(2019) Samantha Sheller-Miller et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles

(2019) Md. Khirul Islam et al.   Scientific Reports

Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques

(2019) Soodeh Salarpour et al.   DARU-Journal of Pharmaceutical Sciences

New insight into isolation, identification techniques and medical applications of exosomes

(2019) Xiao-Xia Yang et al.   JOURNAL OF CONTROLLED RELEASE

Small extracellular vesicle loading systems in cancer therapy: Current status and the way forward

(2019) Yue-Feng Zhang et al.   CYTOTHERAPY

Feasibility of tumor‑derived exosome enrichment in the onco‑hematology leukemic model of chronic myeloid leukemia

(2019) Simona Bernardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration

(2019) Bingrui Wu et al.   ONCOLOGY REPORTS

Acoustofluidic Salivary Exosome Isolation

(2019) Zeyu Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice

(2019) Krishna Prahlad Maremanda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Non-invasive Liquid Biopsy Screening of Urine-Derived Exosomes for miRNAs as Biomarkers in Endometrial Cancer Patients

(2018) Akhil Srivastava et al.   AAPS Journal

Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds

(2018) Ammad Ahmad Farooqi et al.   BIOTECHNOLOGY ADVANCES

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Correction: The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

(2018) Guo-Hong Cui et al.   FASEB JOURNAL

Exosome enrichment by ultracentrifugation and size exclusion chromatography

(2018) Murray D Mitchell   Frontiers in Bioscience-Landmark

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

Serum exosomes can restore cellular function in vitro and be used for diagnosis in dysferlinopathy

(2018) Xue Dong et al.   Theranostics

Advances in plant-derived edible nanoparticle-based lipid nano-drug delivery systems as therapeutic nanomedicines

(2018) Chunhua Yang et al.   Journal of Materials Chemistry B

Preservation of exosomes at room temperature using lyophilization

(2018) Chonlada Charoenviriyakul et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences

(2018) Bowen Fu et al.   Frontiers in Pharmacology

To Protect and to Preserve: Novel Preservation Strategies for Extracellular Vesicles

(2018) Gina D. Kusuma et al.   Frontiers in Pharmacology

Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

(2018) Sophia Antimisiaris et al.   Pharmaceutics

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

(2017) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling

(2017) Ralph D. Sanderson et al.   MATRIX BIOLOGY

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

(2017) Jan Van Deun et al.   NATURE METHODS

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

(2017) Farrukh Aqil et al.   Food & Function

Downregulation of circulating exosomal miR-638 predicts poor prognosis in colon cancer patients

(2017) Shushan Yan et al.   Oncotarget

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

(2017) Lin Cheng et al.   Stem Cells International

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research

(2017) Glenn Vergauwen et al.   Scientific Reports

Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

(2016) Junsung Lee et al.   ACS Applied Materials & Interfaces

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

Exosomal formulation enhances therapeutic response of celastrol against lung cancer

(2016) Farrukh Aqil et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a

(2016) Xiaolei Liang et al.   JOURNAL OF CELL SCIENCE

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer

(2016) Birgitte Sandfeld-Paulsen et al.   Journal of Thoracic Oncology

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Nanoscale lateral displacement arrays for the separation of exosomes and colloids down to 20 nm

(2016) Benjamin H. Wunsch et al.   Nature Nanotechnology

Cells release subpopulations of exosomes with distinct molecular and biological properties

(2016) Eduard Willms et al.   Scientific Reports

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

(2016) Mark A. Rider et al.   Scientific Reports

Trehalose prevents aggregation of exosomes and cryodamage

(2016) Steffi Bosch et al.   Scientific Reports

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

(2015) Yueting Wu et al.   ANALYST

β-Elemene Reverses Chemoresistance of Breast Cancer Cells by Reducing Resistance Transmission via Exosomes

(2015) Jun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics

(2015) Sybren L.N. Maas et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia

(2015) Junhong Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Integrated isolation and quantitative analysis of exosome shuttled proteins and nucleic acids using immunocapture approaches

(2015) Natasa Zarovni et al.   METHODS

Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio

(2015) Tianzhi Yang et al.   PHARMACEUTICAL RESEARCH

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing

(2015) Bin Zhang et al.   STEM CELLS

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol

(2015) Mikhail A. Livshits et al.   Scientific Reports

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

Benchtop isolation and characterization of functional exosomes by sequential filtration

(2014) Mitja L. Heinemann et al.   JOURNAL OF CHROMATOGRAPHY A

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles

(2014) Jingyao Mu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

(2013) Michel Record et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

(2013) Aya D. Pusic et al.   GLIA

OP177

(2013) Ayelet Zlotogorski et al.   ORAL ONCOLOGY

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

(2011) Sanyukta Rana et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples

(2011) Olof Gidlöf et al.   CARDIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

SiRNA delivery with exosome nanoparticles

(2011) Jasper G van den Boorn et al.   NATURE BIOTECHNOLOGY

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury

(2011) S. Gatti et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system

(2010) Gabriel A. Silva   Annals of the New York Academy of Sciences

Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease

(2010) Maarten F. Corsten et al.   Circulation-Cardiovascular Genetics

Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans

(2010) Guo-Kun Wang et al.   EUROPEAN HEART JOURNAL

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Saponins as cytotoxic agents: a review

(2010) Irma Podolak et al.   PHYTOCHEMISTRY REVIEWS

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Proteomics Analysis of A33 Immunoaffinity-purified Exosomes Released from the Human Colon Tumor Cell Line LIM1215 Reveals a Tissue-specific Protein Signature

(2009) Suresh Mathivanan et al.   MOLECULAR & CELLULAR PROTEOMICS

Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants

(2008) Réjean Cantin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE