The Role of Exosomes and Exosomal MicroRNA in Cardiovascular Disease

Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis

(2020) Xiaohui Xing et al.   Aging-US

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

(2020) Hebah A. Sindi et al.   Nature Communications

Mesenchymal stem cell-derived exosomes ameliorate cardiomyocyte apoptosis in hypoxic conditions through microRNA144 by targeting the PTEN/AKT pathway

(2020) Zhuzhi Wen et al.   Stem Cell Research & Therapy

Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway

(2020) Tao Geng et al.   International Journal of Nanomedicine

Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2

(2020) Yi Peng et al.   Cell Death & Disease

Serum exosomal miR-122-5p is a new biomarker for both acute coronary syndrome and underlying coronary artery stenosis

(2020) Hao Ling et al.   BIOMARKERS

Serum Exosomal MicroRNA-21, MicroRNA-126, and PTEN Are Novel Biomarkers for Diagnosis of Acute Coronary Syndrome

(2020) Hao Ling et al.   Frontiers in Physiology

Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis

(2020) Amir B. Ghaemmaghami et al.   Cell Communication and Signaling

Exosomal microRNAs derived from mesenchymal stem cells: cell-to-cell messages

(2020) Kasra Asgarpour et al.   Cell Communication and Signaling

Exosomal microRNAs: novel players in cervical cancer

(2020) Javid Sadri Nahand et al.   Epigenomics

Human mesenchymal stem cell-derived exosomes reduce ischemia/reperfusion injury by the inhibitions of apoptosis and autophagy

(2019) Xiaofei Jiang et al.   CURRENT PHARMACEUTICAL DESIGN

Circulating MiR-17-5p, MiR-126-5p and MiR-145-3p Are Novel Biomarkers for Diagnosis of Acute Myocardial Infarction

(2019) Sheng Xue et al.   Frontiers in Physiology

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

(2019) Alessandra Ciullo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis

(2019) Mark C. Blaser et al.   CIRCULATION RESEARCH

Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization

(2019) Jinxuan Zhao et al.   CARDIOVASCULAR RESEARCH

Potential involvement of S1PR1/STAT3 signaling pathway in cardiac valve damage due to rheumatic heart disease

(2019) X.-D. Wu et al.   BIOTECHNIC & HISTOCHEMISTRY

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

(2019) Jiangbing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intravenous administration of cardiac progenitor cell-derived exosomes protects against doxorubicin/trastuzumab-induced cardiac toxicity

(2019) Giuseppina Milano et al.   CARDIOVASCULAR RESEARCH

Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium

(2019) Progyaparamita Saha et al.   Science Translational Medicine

Exosomes of bone-marrow stromal cells inhibit cardiomyocyte apoptosis under ischemic and hypoxic conditions via miR-486-5p targeting the PTEN/PI3K/AKT signaling pathway

(2019) Xiang-Hua Sun et al.   THROMBOSIS RESEARCH

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

Exosomal miR-301 derived from mesenchymal stem cells protects myocardial infarction by inhibiting myocardial autophagy

(2019) Yong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-145 Protects against Myocardial Ischemia Reperfusion Injury via CaMKII-Mediated Antiapoptotic and Anti-Inflammatory Pathways

(2019) Zhebo Liu et al.   Oxidative Medicine and Cellular Longevity

Mesenchymal Stem Cell Extracellular Vesicles Reverse Sugen/Hypoxia Pulmonary Hypertension in Rats

(2019) James R Klinger et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Dendritic cell exosome‑shuttled miRNA146a regulates exosome‑induced endothelial cell inflammation by inhibiting IRAK‑1: A feedback control mechanism

(2019) Xin Zhong et al.   Molecular Medicine Reports

Extracellular MicroRNA-92a Mediates Endothelial Cell–Macrophage Communication

(2019) Ya-Ju Chang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differentially expressed microRNA profiles in exosomes from vascular smooth muscle cells associated with coronary artery calcification

(2019) Wei Pan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease

(2019) Ang Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells

(2018) Marthe F.S. Lindenbergh et al.   Annual Review of Immunology

The lncRNA TUG1/miR-145-5p/FGF10 regulates proliferation and migration in VSMCs of hypertension

(2018) Lin Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A

(2018) Lucio Barile et al.   CARDIOVASCULAR RESEARCH

MicroRNA

(2018) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Exosomes, the message transporters in vascular calcification

(2018) Chao Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal miR-21a-5p mediates cardioprotection by mesenchymal stem cells

(2018) Kristin M. Luther et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reduced exosome miR-425 and miR-744 in the plasma represents the progression of fibrosis and heart failure

(2018) Lu Wang et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Endothelial extracellular vesicles modulate the macrophage phenotype: Potential implications in atherosclerosis

(2018) S. He et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction

(2018) Kirsty M. Danielson et al.   EBioMedicine

miR-143 and miR-145 promote hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells through regulating ABCA1 expression

(2018) Yuxia Yue et al.   CARDIOVASCULAR PATHOLOGY

Exosomes/microvesicles microRNA-423-3p derived from cardiac fibroblasts mediates the cardioprotective effects of ischemic postconditioning

(2018) Hui Luo et al.   CARDIOVASCULAR RESEARCH

Mesenchymal Stem Cell-Mediated Autophagy Inhibition

(2018) Benjamin P. Woodall et al.   CIRCULATION RESEARCH

MiR-145 expression and rare NOTCH1 variants in bicuspid aortic valve-associated aortopathy

(2018) Evaldas Girdauskas et al.   PLoS One

Post-transcriptional control of miRNA biogenesis

(2018) Gracjan Michlewski et al.   RNA

The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease

(2018) Francesca Vacante et al.   VASCULAR PHARMACOLOGY

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Circulating exosomal miR-92b-5p is a promising diagnostic biomarker of heart failure with reduced ejection fraction patients hospitalized for acute heart failure

(2018) Tao Wu et al.   Journal of Thoracic Disease

Exosomes derived miR-126 attenuates oxidative stress and apoptosis from ischemia and reperfusion injury by targeting ERRFI1

(2018) Wenyi Wang et al.   GENE

Role of the immune system in cardiac tissue damage and repair following myocardial infarction

(2017) Arman Saparov et al.   INFLAMMATION RESEARCH

Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis

(2017) Bin Zheng et al.   MOLECULAR THERAPY

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response

(2017) Jiannan Li et al.   THROMBOSIS RESEARCH

MicroRNA in cardiovascular biology and disease

(2017) Anna Wojciechowska et al.   Advances in Clinical and Experimental Medicine

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

(2017) My-Anh Nguyen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inducible miR-145 expression by HIF-1α protects cardiomyocytes against apoptosis via regulating SGK1 in simulated myocardial infarction hypoxic microenvironment

(2017) Nianzi Sun et al.   Cardiology Journal

Circulating miR-155, miR-145 and let-7c as diagnostic biomarkers of the coronary artery disease

(2017) Julien Faccini et al.   Scientific Reports

Autophagy and the endo/exosomal pathways in health and disease

(2016) Margarita-Elena Papandreou et al.   Biotechnology Journal

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

Cortactin promotes exosome secretion by controlling branched actin dynamics

(2016) Seema Sinha et al.   JOURNAL OF CELL BIOLOGY

Regulation of chronic inflammatory and immune processes by extracellular vesicles

(2016) Paul D. Robbins et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging roles for vascular smooth muscle cell exosomes in calcification and coagulation

(2016) A. N. Kapustin et al.   JOURNAL OF PHYSIOLOGY-LONDON

miR-145 mediated the role of aspirin in resisting VSMCs proliferation and anti-inflammation through CD40

(2016) Xin Guo et al.   Journal of Translational Medicine

miRNA Biogenesis: A Dynamic Pathway

(2016) Natalia P. Achkar et al.   TRENDS IN PLANT SCIENCE

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21

(2016) Kan Wang et al.   Stem Cells Translational Medicine

Autophagy and the endo/exosomal pathways in health and disease

(2016) Margarita-Elena Papandreou et al.   Biotechnology Journal

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Rheumatic Heart Disease: Causes, Symptoms, and Treatments

(2015) Min Liu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction

(2015) M. Khan et al.   CIRCULATION RESEARCH

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

Novel directions in inflammation as a therapeutic target in atherosclerosis

(2015) Simone L. Verweij et al.   CURRENT OPINION IN LIPIDOLOGY

Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial)

(2015) Anders Bruun Mathiasen et al.   EUROPEAN HEART JOURNAL

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

(2015) Borja Ibáñez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Mesenchymal stem cells attenuate acute ischemia-reperfusion injury in a rat model

(2015) WEIFENG LU et al.   Experimental and Therapeutic Medicine

Runx2/miR-3960/miR-2861 Positive Feedback Loop Is Responsible for Osteogenic Transdifferentiation of Vascular Smooth Muscle Cells

(2015) Zhu-Ying Xia et al.   Biomed Research International

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Cross Talk of Combined Gene and Cell Therapy in Ischemic Heart Disease: Role of Exosomal MicroRNA Transfer

(2014) S.-G. Ong et al.   CIRCULATION

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Exosomes and Cardiac Repair After Myocardial Infarction

(2014) Susmita Sahoo et al.   CIRCULATION RESEARCH

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

(2014) Lars Maegdefessel et al.   Nature Communications

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity

(2013) Rajamma Mathew   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease

(2013) Maarten Hulsmans et al.   CARDIOVASCULAR RESEARCH

Aneurysm Global Epidemiology Study

(2013) David Sidloff et al.   CIRCULATION

Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice

(2013) Xavier Loyer et al.   CIRCULATION RESEARCH

Intercellular Communication by Exosome-Derived microRNAs in Cancer

(2013) Bethany Hannafon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Flank Sequences of miR‐145/143 and Their Aberrant Expression in Vascular Disease: Mechanism and Therapeutic Application

(2013) Xiaojun Liu et al.   Journal of the American Heart Association

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

MicroRNA-145 Targeted Therapy Reduces Atherosclerosis

(2012) F. Lovren et al.   CIRCULATION

Vascular Smooth Muscle Cell Sirtuin 1 Protects Against DNA Damage and Inhibits Atherosclerosis

(2012) Isabelle Gorenne et al.   CIRCULATION

A Role for miR-145 in Pulmonary Arterial Hypertension

(2012) Paola Caruso et al.   CIRCULATION RESEARCH

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

MicroRNAs that target Ca2+ transporters are involved in vascular smooth muscle cell calcification

(2012) Ting Gui et al.   LABORATORY INVESTIGATION

Rheumatic heart disease

(2012) Eloi Marijon et al.   LANCET

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Management of Abdominal Aortic Aneurysms Clinical Practice Guidelines of the European Society for Vascular Surgery

(2011) F.L. Moll et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

CELL BIOLOGY: No ESCRTs for Exosomes

(2008) M. Marsh et al.   SCIENCE