Development of New Strategies Using Extracellular Vesicles Loaded with Exogenous Nucleic Acid

Direct comparison of optical and electron microscopy methods for structural characterization of extracellular vesicles

(2020) Jade M. Noble et al.   JOURNAL OF STRUCTURAL BIOLOGY

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes

(2020) Max Tschuschke et al.   Journal of Clinical Medicine

RNA delivery by extracellular vesicles in mammalian cells and its applications

(2020) Killian O’Brien et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging small molecule-induced endosomal escape of siRNA

(2020) Hampus Du Rietz et al.   Nature Communications

Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors

(2019) Hildegard Büning et al.   Molecular Therapy-Methods & Clinical Development

Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Diseases

(2019) Tao-Tao Tang et al.   Frontiers in Physiology

Adeno-Associated Viral Vectors as a Tool for Large Gene Delivery to the Retina

(2019) Trapani   Genes

Exosomes regulate neurogenesis and circuit assembly

(2019) Pranav Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance

(2019) Tanita Wein et al.   Nature Communications

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

How to Choose the Right Inducible Gene Expression System for Mammalian Studies?

(2019) Kallunki et al.   Cells

Extracellular Vesicles and Their Potential Use in Monitoring Cancer Progression and Therapy: The Contribution of Proteomics

(2019) Maria Concetta Cufaro et al.   Journal of Oncology

Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

(2019) Nicola Salvatore Orefice et al.   Molecular Therapy-Methods & Clinical Development

Evaluation of novel cationic gene based liposomes with cyclodextrin prepared by thin film hydration and microfluidic systems

(2019) Hassan Elsana et al.   Scientific Reports

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

(2019) Liuwan Zhao et al.   JOURNAL OF CONTROLLED RELEASE

Contribution of the exosome-associated form of secreted endoplasmic reticulum aminopeptidase 1 to exosome-mediated macrophage activation

(2018) Yoshikuni Goto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FDA approves hereditary blindness gene therapy

(2018)   NATURE BIOTECHNOLOGY

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Linear mitochondrial DNA is rapidly degraded by components of the replication machinery

(2018) Viktoriya Peeva et al.   Nature Communications

Expression and replication of virus-like circular DNA in human cells

(2018) Sebastian Eilebrecht et al.   Scientific Reports

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Pharmacology of Recombinant Adeno-associated Virus Production

(2018) Magalie Penaud-Budloo et al.   Molecular Therapy-Methods & Clinical Development

Enhanced Production of Exosome-Associated AAV by Overexpression of the Tetraspanin CD9

(2018) Lara Timantra Schiller et al.   Molecular Therapy-Methods & Clinical Development

Intercellular Spread of Protein Aggregates in Neurodegenerative Disease

(2018) Albert A. Davis et al.   Annual Review of Cell and Developmental Biology

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

Replicate Once Per Cell Cycle: Replication Control of Secondary Chromosomes

(2018) Florian Fournes et al.   Frontiers in Microbiology

Nano based drug delivery systems: recent developments and future prospects

(2018) Jayanta Kumar Patra et al.   JOURNAL OF NANOBIOTECHNOLOGY

Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65

(2018) Eloise Hudry et al.   Molecular Therapy-Methods & Clinical Development

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

(2018) Wen Liao et al.   Acta Biomaterialia

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

(2018) Dan Wang et al.   Molecular Therapy-Methods & Clinical Development

Rapid AAV-Neutralizing Antibody Determination with a Cell-Binding Assay

(2018) Ping Guo et al.   Molecular Therapy-Methods & Clinical Development

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial

(2017) Céline Vandamme et al.   HUMAN GENE THERAPY

Impact of AAV Capsid-Specific T-Cell Responses on Design and Outcome of Clinical Gene Transfer Trials with Recombinant Adeno-Associated Viral Vectors: An Evolving Controversy

(2017) Hildegund C.J. Ertl et al.   HUMAN GENE THERAPY

Regulatory and Exhausted T Cell Responses to AAV Capsid

(2017) Gwladys Gernoux et al.   HUMAN GENE THERAPY

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Rescue of Hearing by Gene Delivery to Inner-Ear Hair Cells Using Exosome-Associated AAV

(2017) Bence György et al.   MOLECULAR THERAPY

Extracellular vesicles: nature's nanoparticles for improving gene transfer with adeno-associated virus vectors

(2017) Bence György et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

(2017) Sarah J. Wassmer et al.   Scientific Reports

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting

(2017) Livia S. Carvalho et al.   Frontiers in Neuroscience

Biomimetic Lipid-Based Nanosystems for Enhanced Dermal Delivery of Drugs and Bioactive Agents

(2017) Niranjan G. Kotla et al.   ACS Biomaterials-Science & Engineering

Biomimetic Lipid-Based Nanosystems for Enhanced Dermal Delivery of Drugs and Bioactive Agents

(2017) Niranjan G. Kotla et al.   ACS Biomaterials Science & Engineering

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?

(2017) Yoon-Ju Lim et al.   Acta Neuropathologica Communications

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

(2016) Kasper Bendix Johnsen et al.   CYTOTECHNOLOGY

Exosome-associated AAV vector as a robust and convenient neuroscience tool

(2016) E Hudry et al.   GENE THERAPY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Transfer of DNA from Bacteria to Eukaryotes

(2016) Benoît Lacroix et al.   mBio

Adenovirus sensing by the immune system

(2016) Svetlana Atasheva et al.   Current Opinion in Virology

Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids

(2016) Kyle Chamberlain et al.   Human Gene Therapy Methods

Manufacturing of recombinant adeno-associated viral vectors for clinical trials

(2016) Nathalie Clément et al.   Molecular Therapy-Methods & Clinical Development

17. Targeted Delivery of Plasmid DNA and siRNA with Modified Dendritic Cell-Derived Exosomes

(2016)   MOLECULAR THERAPY

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

Treatment of ocular disorders by gene therapy

(2015) M. Ángeles Solinís et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Strategies to circumvent humoral immunity to adeno-associated viral vectors

(2015) Longping V Tse et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Capsosomes as Long-Term Delivery Vehicles for Protein Therapeutics

(2015) James W. Maina et al.   LANGMUIR

Survival of Enveloped and Non-Enveloped Viruses on Inanimate Surfaces

(2015) Swan Firquet et al.   MICROBES AND ENVIRONMENTS

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Membrane Disintegration Caused by the Steroid Saponin Digitonin Is Related to the Presence of Cholesterol

(2015) Ikhwan Sudji et al.   MOLECULES

Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis

(2015) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of Eleven Methods for Genomic DNA Extraction Suitable for Large-Scale Whole-Genome Genotyping and Long-Term DNA Banking Using Blood Samples

(2015) Androniki Psifidi et al.   PLoS One

Emerging picture of the distinct traits and functions of microvesicles and exosomes

(2015) Marc A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A comparison of AAV strategies distinguishes overlapping vectors for efficient systemic delivery of the 6.2 kb Dysferlin coding sequence

(2015) Marina Pryadkina et al.   Molecular Therapy-Methods & Clinical Development

Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo

(2014) Bence György et al.   BIOMATERIALS

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

DNA Ministrings: Highly Safe and Effective Gene Delivery Vectors

(2014) Nafiseh Nafissi et al.   Molecular Therapy-Nucleic Acids

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

Adeno-associated virus structural biology as a tool in vector development

(2013) Lauren M Drouin et al.   Future Virology

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Biomimetic Liposome- and Polymersome-Based Multicompartmentalized Assemblies

(2012) Rona Chandrawati et al.   LANGMUIR

Minimizing the Inhibitory Effect of Neutralizing Antibody for Efficient Gene Expression in the Liver With Adeno-associated Virus 8 Vectors

(2012) Jun Mimuro et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Proteasome Inhibition Is Partially Effective in Attenuating Pre-Existing Immunity against Recombinant Adeno-Associated Viral Vectors

(2012) Jozsef Karman et al.   PLoS One

Implications of the innate immune response to adenovirus and adenoviral vectors

(2011) Seth M Gregory et al.   Future Virology

Humoral Immunity to AAV-6, 8, and 9 in Normal and Dystrophic Dogs

(2011) Jin-Hong Shin et al.   HUMAN GENE THERAPY

Compartmentalized reactions as a case of soft-matter biotechnology: synthesis of proteins and nucleic acids inside lipid vesicles

(2011) Pasquale Stano et al.   JOURNAL OF MATERIALS CHEMISTRY

Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models

(2011) Kleopatra Rapti et al.   MOLECULAR THERAPY

Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector

(2011) Dawn E Bowles et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Immune Responses to rAAV6: The Influence of Canine Parvovirus Vaccination and Neonatal Administration of Viral Vector

(2011) Andrea L. H. Arnett et al.   Frontiers in Microbiology

Mammalian cell transfection: the present and the future

(2010) Tae Kyung Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Introducing the bacterial ‘chromid’: not a chromosome, not a plasmid

(2010) Peter W. Harrison et al.   TRENDS IN MICROBIOLOGY

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

(2009) E Ayuso et al.   GENE THERAPY

Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection

(2009) Richard N. Cohen et al.   JOURNAL OF CONTROLLED RELEASE

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Somatic evolutionary genomics: Mutations during development cause highly variable genetic mosaicism with risk of cancer and neurodegeneration

(2009) S. A. Frank   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liposomes: Technologies and Analytical Applications

(2008) Aldo Jesorka et al.   Annual Review of Analytical Chemistry

Gene Therapy Using Adeno-Associated Virus Vectors

(2008) S. Daya et al.   CLINICAL MICROBIOLOGY REVIEWS

Manufacturing and characterizing AAV-based vectors for use in clinical studies

(2008) J F Wright   GENE THERAPY

Adaptive Plasmid Evolution Results in Host-Range Expansion of a Broad-Host-Range Plasmid

(2008) L. De Gelder et al.   GENETICS

Adeno-Associated Virus Vector Genomes Persist as Episomal Chromatin in Primate Muscle

(2008) M. Penaud-Budloo et al.   JOURNAL OF VIROLOGY

Recombinant Adeno-associated Virus Transduction and Integration

(2008) Brian R Schultz et al.   MOLECULAR THERAPY