Phenotypic analysis of extracellular vesicles: a review on the applications of fluorescence

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

(2019) Frederik J. Verweij et al.   DEVELOPMENTAL CELL

Extracellular vesicle measurements with nanoparticle tracking analysis – An accuracy and repeatability comparison between NanoSight NS300 and ZetaView

(2019) Daniel Bachurski et al.   Journal of Extracellular Vesicles

Multiplexed Profiling of Single Extracellular Vesicles

(2018) Kyungheon Lee et al.   ACS Nano

Wash-free instant detection of giant plasma membrane vesicles

(2018) Saya Okada et al.   ANALYTICAL BIOCHEMISTRY

Nanoparticle Counting by Microscopic Digital Detection: Selective Quantitative Analysis of Exosomes via Surface-Anchored Nucleic Acid Amplification

(2018) Qingchang Tian et al.   ANALYTICAL CHEMISTRY

PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles

(2018) Pia Pužar Dominkuš et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

(2018) Mark Barok et al.   BMC CANCER

Endogenous exosome labelling with an amphiphilic NIR-fluorescent probe

(2018) Marco P. Monopoli et al.   CHEMICAL COMMUNICATIONS

Imaging of extracellular vesicles derived from human bone marrow mesenchymal stem cells using fluorescent and magnetic labels

(2018) Sylwia Dabrowska et al.   International Journal of Nanomedicine

FLIM reveals alternative EV-mediated cellular up-take pathways of paclitaxel

(2018) H. Saari et al.   JOURNAL OF CONTROLLED RELEASE

Isolation of anti-extra-cellular vesicle single-domain antibodies by direct panning on vesicle-enriched fractions

(2018) Milica Popovic et al.   Microbial Cell Factories

Single-Exosome-Counting Immunoassays for Cancer Diagnostics

(2018) Chunchen Liu et al.   NANO LETTERS

Technical challenges of working with extracellular vesicles

(2018) Marcel I. Ramirez et al.   Nanoscale

Gold–carbon dots for the intracellular imaging of cancer-derived exosomes

(2018) Xiaoyue Jiang et al.   NANOTECHNOLOGY

Single molecule localization imaging of exosomes using blinking silicon quantum dots

(2018) Shenfei Zong et al.   NANOTECHNOLOGY

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth

(2018) Jezid Miranda et al.   PLACENTA

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

DNase I enzyme-aided fluorescence signal amplification based on graphene oxide-DNA aptamer interactions for colorectal cancer exosome detection

(2018) Hui Wang et al.   TALANTA

Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles

(2018) Eduardo Reátegui et al.   Nature Communications

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

(2018) Maria Yu. Konoshenko et al.   Biomed Research International

Rapid Detection and Trapping of Extracellular Vesicles by Electrokinetic Concentration for Liquid Biopsy on Chip

(2018) Lucia Cheung et al.   Micromachines

Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses

(2018) Gautam N. Shenoy et al.   Cancer Immunology Research

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

(2018) Juan Carlos Polanco et al.   Acta Neuropathologica Communications

Visualization and intracellular dynamic tracking of exosomes and exosomal miRNAs using single molecule localization microscopy

(2018) Chen Chen et al.   Nanoscale

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

(2018) Sander A. A. Kooijmans et al.   Nanoscale

Lab-on-Chip for Exosomes and Microvesicles Detection and Characterization

(2018) Maria Chiriacò et al.   SENSORS

Imaging of human cells exposed to an antifungal antibiotic amphotericin B reveals the mechanisms associated with the drug toxicity and cell defence

(2018) Ewa Grela et al.   Scientific Reports

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

(2018) Mariangela Garofalo et al.   Viruses-Basel

A nano flow cytometer for single lipid vesicle analysis

(2017) Remo Friedrich et al.   LAB ON A CHIP

Imaging flow cytometry for the characterization of extracellular vesicles

(2017) Joanne Lannigan et al.   METHODS

Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation

(2017) Omar Elfeky et al.   PLACENTA

Detection of tissue factor-positive extracellular vesicles by laser scanning confocal microscopy

(2017) Yohei Hisada et al.   THROMBOSIS RESEARCH

A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection

(2017) Jiaming Hu et al.   Nature Communications

Exosomes Isolated from Ascites of T-Cell Lymphoma-Bearing Mice Expressing Surface CD24 and HSP-90 Induce a Tumor-Specific Immune Response

(2017) Florencia Menay et al.   Frontiers in Immunology

Extracellular vesicles mediate signaling between the aqueous humor producing and draining cells in the ocular system

(2017) Natalie Lerner et al.   PLoS One

Imaging and Intracellular Tracking of Cancer-Derived Exosomes Using Single-Molecule Localization-Based Super-Resolution Microscope

(2016) Chen Chen et al.   ACS Applied Materials & Interfaces

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

(2016) Jina Ko et al.   ANALYST

Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells

(2016) Kyung Jin Son et al.   ANALYST

Intrinsically Labeled Fluorescent Oligonucleotide Probes on Quantum Dots for Transduction of Nucleic Acid Hybridization

(2016) Anna Shahmuradyan et al.   ANALYTICAL CHEMISTRY

Development of exosome surface display technology in living human cells

(2016) Zachary Stickney et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overcoming limitations of FRET measurements

(2016) Silas J. Leavesley et al.   CYTOMETRY PART A

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating

(2016) Peng Zhang et al.   LAB ON A CHIP

A Blue-Light-Emitting BODIPY Probe for Lipid Membranes

(2016) Mihaela Bacalum et al.   LANGMUIR

Nanoparticle metrology of silica colloids and super-resolution studies using the ADOTA fluorophore

(2016) Hazel L Stewart et al.   MEASUREMENT SCIENCE and TECHNOLOGY

Flow analysis of individual blood extracellular vesicles in acute coronary syndrome

(2016) Murad Vagida et al.   PLATELETS

Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

(2016) Rebecca Macklin et al.   Oncotarget

Nanobodies as Versatile Tools to Understand, Diagnose, Visualize and Treat Cancer

(2016) Isabel Van Audenhove et al.   EBioMedicine

Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF)

(2016) Johnny C. Akers et al.   PLoS One

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

(2016) Barbara W Sódar et al.   Scientific Reports

Smartphone-enabled optofluidic exosome diagnostic for concussion recovery

(2016) Jina Ko et al.   Scientific Reports

Extracellular vesicle microRNAs: biomarker discovery in various diseases based on RT-qPCR

(2015) Ying Liu et al.   Biomarkers in Medicine

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

SRYgene transferred by extracellular vesicles accelerates atherosclerosis by promotion of leucocyte adherence to endothelial cells

(2015) Jin Cai et al.   CLINICAL SCIENCE

High sensitivity flow cytometry of membrane vesicles

(2015) Samuel A. Stoner et al.   CYTOMETRY PART A

Analytical challenges of extracellular vesicle detection: A comparison of different techniques

(2015) Uta Erdbrügger et al.   CYTOMETRY PART A

Prerequisites for the analysis and sorting of extracellular vesicle subpopulations by high-resolution flow cytometry

(2015) Tom Groot Kormelink et al.   CYTOMETRY PART A

Surface plasmon enhanced energy transfer between gold nanorods and fluorophores: application to endocytosis study and RNA detection

(2015) Yinan Zhang et al.   FARADAY DISCUSSIONS

Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics

(2015) Sybren L.N. Maas et al.   JOURNAL OF CONTROLLED RELEASE

Practical limitations of superresolution imaging due to conventional sample preparation revealed by a direct comparison of CLSM, SIM and dSTORM

(2015) MICHAEL BACHMANN et al.   JOURNAL OF MICROSCOPY

Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain

(2015) Kristan E. van der Vos et al.   NEURO-ONCOLOGY

A high speed multifocal multiphoton fluorescence lifetime imaging microscope for live-cell FRET imaging

(2015) Simon P. Poland et al.   Biomedical Optics Express

Single-Molecule Localization Microscopy allows for the analysis of cancer metastasis-specific miRNA distribution on the nanoscale

(2015) Olga Oleksiuk et al.   Oncotarget

Surface plasmon enhanced energy transfer between gold nanorods and fluorophores: application to endocytosis study and RNA detection

(2015) Yinan Zhang et al.   FARADAY DISCUSSIONS

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Small Quantum Dots Conjugated to Nanobodies as Immunofluorescence Probes for Nanometric Microscopy

(2014) Yong Wang et al.   BIOCONJUGATE CHEMISTRY

Super-resolution Microscopy Approaches for Live Cell Imaging

(2014) Antoine G. Godin et al.   BIOPHYSICAL JOURNAL

Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry

(2014) Uta Erdbrügger et al.   CYTOMETRY PART A

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

(2014) CRISTINA GRANGE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

(2014) Mei He et al.   LAB ON A CHIP

Microfluidic device (ExoChip) for on-chip isolation, quantification and characterization of circulating exosomes

(2014) Shailender Singh Kanwar et al.   LAB ON A CHIP

Proton-induced endocytosis is dependent on cell membrane fluidity, lipid-phase order and the membrane resting potential

(2013) Nadav Ben-Dov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Intraoperative fluorescence delineation of head and neck cancer with a fluorescent Anti-epidermal growth factor receptor nanobody

(2013) P.B.A.A. van Driel et al.   INTERNATIONAL JOURNAL OF CANCER

Intercellular Communication by Exosome-Derived microRNAs in Cancer

(2013) Bethany Hannafon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Luminescent nanoparticles and their applications in the life sciences

(2013) Varun K A Sreenivasan et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Quantification of human urinary exosomes by nanoparticle tracking analysis

(2013) Wilna Oosthuyzen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Innovation in detection of microparticles and exosomes

(2013) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Characterization of a New Series of Fluorescent Probes for Imaging Membrane Order

(2013) Joanna M. Kwiatek et al.   PLoS One

Azadioxatriangulenium: a long fluorescence lifetime fluorophore for large biomolecule binding assay

(2013) Thomas Just Sørensen et al.   Methods and Applications in Fluorescence

Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients

(2012) Cicek Gercel-Taylor et al.   ANALYTICAL BIOCHEMISTRY

Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells

(2012) Chin Y. Soo et al.   IMMUNOLOGY

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

A simple, versatile method for GFP-based super-resolution microscopy via nanobodies

(2012) Jonas Ries et al.   NATURE METHODS

Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry

(2012) Els J van der Vlist et al.   Nature Protocols

Super-resolution microscopy at a glance

(2011) C. G. Galbraith et al.   JOURNAL OF CELL SCIENCE

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

(2011) Rebecca A. Dragovic et al.   Nanomedicine-Nanotechnology Biology and Medicine

Direct stochastic optical reconstruction microscopy with standard fluorescent probes

(2011) Sebastian van de Linde et al.   Nature Protocols

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

(2010) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Overcoming Limitations of Microparticle Measurement by Flow Cytometry

(2010) Romaric Lacroix et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

Why do cells release vesicles?

(2010) Rienk Nieuwland et al.   THROMBOSIS RESEARCH

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

(2009) J Nilsson et al.   BRITISH JOURNAL OF CANCER

Horizontal transfer of tumor DNA to endothelial cells in vivo

(2009) J Ehnfors et al.   CELL DEATH AND DIFFERENTIATION

Lipophilic Dye Staining ofCryptococcus neoformansExtracellular Vesicles and Capsule

(2009) André Moraes Nicola et al.   EUKARYOTIC CELL

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Video-Rate Far-Field Optical Nanoscopy Dissects Synaptic Vesicle Movement

(2008) V. Westphal et al.   SCIENCE