Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

Helicobacter pylori Subdues Cytokine Signaling to Alter Mucosal Inflammation via Hypermethylation of Suppressor of Cytokine Signaling 1 Gene During Gastric Carcinogenesis

(2021) Iqra Jan et al.   Frontiers in Oncology

A primer on cytokines

(2021) Prashant Chauhan et al.   CYTOKINE

Complexation with Random Methyl-β-Cyclodextrin and (2-Hidroxypropyl)-β-Cyclodextrin Enhances In Vivo Anti-Fibrotic and Anti-Inflammatory Effects of Chrysin via the Inhibition of NF-κB and TGF-β1/Smad Signaling Pathways and Modulation of Hepatic Pro/Anti-Fibrotic miRNA

(2021) Alina Ciceu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In silico drug discovery for a complex immunotherapeutic target - human c-Rel protein

(2021) Austė Kanapeckaitė et al.   BIOPHYSICAL CHEMISTRY

TGF‐β signaling: A recap of SMAD‐independent and SMAD‐dependent pathways

(2021) Sabreena Aashaq et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer

(2021) Bilal Rah et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An Update

(2021) Pía Loren et al.   Pharmaceuticals

The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance

(2021) Bikash Chandra Jena et al.   CANCER LETTERS

Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency

(2020) Raffaella Rossetti et al.   HUMAN MUTATION

Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma

(2020) Antje Wick et al.   INVESTIGATIONAL NEW DRUGS

SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis

(2020) Chuandong Lang et al.   Molecular Oncology

Anti-Inflammatory Drugs as Anticancer Agents

(2020) Silvia Zappavigna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AVID200, first-in-class TGF-beta 1 and 3 selective and potent inhibitor: Safety and biomarker results of a phase I monotherapy dose-escalation study in patients with advanced solid tumors.

(2020) Timothy A Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Lipid regulation and transport in membrane remodeling

(2020) Francesca Giordano et al.   MOLECULAR BIOLOGY OF THE CELL

JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

(2020) Azucena Salas et al.   Nature Reviews Gastroenterology & Hepatology

Targeting Mouse Double Minute 2: Current Concepts in DNA Damage Repair and Therapeutic Approaches in Cancer

(2020) Wen Li et al.   Frontiers in Pharmacology

Mechanisms of JAK‑STAT signaling pathway mediated by CXCL8 gene silencing on epithelial‑mesenchymal transition of human cutaneous melanoma cells

(2020) Xiaorui Hu et al.   Oncology Letters

SMAD‑6, ‑7 and ‑9 are potential molecular biomarkers for the prognosis in human lung cancer

(2020) Shuxian Pan et al.   Oncology Letters

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

(2020) Sankhadip Bose et al.   Cells

The role of MDM2–p53 axis dysfunction in the hepatocellular carcinoma transformation

(2020) Hui Cao et al.   Cell Death Discovery

STAT3 transcription factor as target for anti-cancer therapy

(2020) Aliaa M. Mohassab et al.   Pharmacological Reports

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

(2020) Rui Liu et al.   Cell Death & Disease

Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights

(2020) Fatemeh Heydarpour et al.   Frontiers in Pharmacology

Targeting the JAK/STAT Signaling Pathway for Breast Cancer.

(2020) Fei Shao et al.   CURRENT MEDICINAL CHEMISTRY

TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

(2019) Veenu Tripathi et al.   ONCOGENE

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

(2019) Chin-Yap Loh et al.   Frontiers in Oncology

LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway

(2019) Xinghan Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer

(2019) Norelia Torrealba et al.   Aging Male

Proton pump inhibitors promote the growth of androgen-sensitive prostate cancer cells through ErbB2, ERK1/2, PI3K/Akt, GSK-3β signaling and inhibition of cellular prostatic acid phosphatase

(2019) Iacopo Gesmundo et al.   CANCER LETTERS

Long noncoding RNA ELIT-1 acts as a Smad3 cofactor to facilitate TGF-β/Smad signaling and promote epithelial-mesenchymal transition

(2019) Satoshi Sakai et al.   CANCER RESEARCH

Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC)

(2019) Catharina Melzer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis

(2019) Yang Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The adaptogenic anti-ageing potential of resveratrol against heat stress-mediated liver injury in aged rats: Role of HSP70 and NF-kB signalling

(2019) Asmaa F. Khafaga et al.   JOURNAL OF THERMAL BIOLOGY

An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms

(2019) Simon Mitchell et al.   Frontiers in Immunology

PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics

(2019) Alia Ghoneum et al.   Cancers

Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma

(2019) Panagiotis Papoutsoglou et al.   Cells

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling

(2019) Fernando de la Cuesta et al.   Cell Communication and Signaling

Distinct functions of AKT isoforms in breast cancer: a comprehensive review

(2019) Nico Hinz et al.   Cell Communication and Signaling

Role of regulatory miRNAs of the PI3K/AKT/mTOR signaling in the pathogenesis of hepatocellular carcinoma

(2019) Farzad Rahmani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in Splicing Factor Genes in Myeloid Malignancies: Significance and Impact on Clinical Features

(2019) Valeria Visconte et al.   Cancers

TGFβ Family Signaling Pathways in Pluripotent and Teratocarcinoma Stem Cells’ Fate Decisions: Balancing Between Self-Renewal, Differentiation, and Cancer

(2019) Olga Gordeeva   Cells

Contextual Regulation of TGF-β Signaling in Liver Cancer

(2019) Tu et al.   Cells

Parthenolide, an NF-κB inhibitor, alleviates peritoneal fibrosis by suppressing the TGF-β/Smad pathway

(2019) Ying Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

STAT5: From Pathogenesis Mechanism to Therapeutic Approach in Acute Leukemia

(2019) Mohammad Shahjahani et al.   Labmedicine

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

(2018) Tatsuo Hata et al.   AMERICAN JOURNAL OF PATHOLOGY

Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment

(2018) Lin Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

The regulation of JAKs in cytokine signaling and its breakdown in disease

(2018) Henrik M. Hammarén et al.   CYTOKINE

The role of TGF-β/SMAD4 signaling in cancer

(2018) Ming Zhao et al.   International Journal of Biological Sciences

A phase 1b study of transforming growth factor-beta receptor I inhibitor galunisertib in combination with sorafenib in Japanese patients with unresectable hepatocellular carcinoma

(2018) Masafumi Ikeda et al.   INVESTIGATIONAL NEW DRUGS

Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway

(2018) Yen-Hsiu Yeh et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone

(2018) Youngin Kwon et al.   LABORATORY INVESTIGATION

Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products

(2018) Kodappully S. Siveen et al.   Molecular Cancer

PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy

(2018) Nahal Haddadi et al.   Molecular Cancer

FoxO transcription factors in cancer metabolism

(2018) Raj Kumar Yadav et al.   SEMINARS IN CANCER BIOLOGY

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis

(2018) Katsunori Yoshida et al.   Cancers

Differential regulation of NF-kB and IRF target genes as they relate to fatigue in patients with head and neck cancer

(2018) Canhua Xiao et al.   BRAIN BEHAVIOR AND IMMUNITY

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

(2018) Alessandro Bertero et al.   NATURE

miR-218 overexpression suppresses tumorigenesis of papillary thyroid cancer via inactivation of PTEN /PI3K/AKT pathway by targeting Runx2

(2018) Mingkun Han et al.   OncoTargets and Therapy

Interleukin-6 and Type-I Collagen Production by Systemic Sclerosis Fibroblasts Are Differentially Regulated by Interleukin-17A in the Presence of Transforming Growth Factor-Beta 1

(2018) Aleksandra Maria Dufour et al.   Frontiers in Immunology

Smurfs in Protein Homeostasis, Signaling, and Cancer

(2018) Praveen Koganti et al.   Frontiers in Oncology

“Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway

(2018) Emira Bousoik et al.   Frontiers in Oncology

Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway

(2018) Tiffany J. Rios-Fuller et al.   Oncotarget

DT-13 Inhibits Proliferation and Metastasis of Human Prostate Cancer Cells Through Blocking PI3K/Akt Pathway

(2018) Zhengming Wang et al.   Frontiers in Pharmacology

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells

(2017) Ana Rodríguez-García et al.   FEBS Journal

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway

(2017) Zhiliang Lu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Jak Stat signaling and cancer: Opportunities, benefits and side effects of targeted inhibition

(2017) Bernd Groner et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling

(2017) Yi Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators

(2017) Ignacio Norambuena-Soto et al.   BioScience Trends

Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection

(2017) Shomyseh Sanjabi et al.   Cold Spring Harbor Perspectives in Biology

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

(2017) R E Piddock et al.   Blood Cancer Journal

Inflammatory responses and inflammation-associated diseases in organs

(2017) Linlin Chen et al.   Oncotarget

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor

(2017) Jonathan M. Yingling et al.   Oncotarget

Interactions between TGF-β1, canonical WNT/β-catenin pathway and PPAR γ in radiation-induced fibrosis

(2017) Alexandre Vallée et al.   Oncotarget

PI3K: A Crucial Piece in the RAS Signaling Puzzle

(2017) Agata Adelajda Krygowska et al.   Cold Spring Harbor Perspectives in Medicine

Peficitinib, a JAK Inhibitor, in Combination With Limited Conventional Synthetic Disease-Modifying Antirheumatic Drugs in the Treatment of Moderate-to-Severe Rheumatoid Arthritis

(2017) Mark C. Genovese et al.   Arthritis & Rheumatology

miR-133a Promotes TRAIL Resistance in Glioblastoma via Suppressing Death Receptor 5 and Activating NF-κB Signaling

(2017) Shan-shan Wang et al.   Molecular Therapy-Nucleic Acids

AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress

(2017) R U Rasool et al.   Oncogenesis

Canonical and Non-Canonical Aspects of JAK–STAT Signaling: Lessons from Interferons for Cytokine Responses

(2017) Andrea Majoros et al.   Frontiers in Immunology

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

(2017) Sunjida Ahmed et al.   Journal of Clinical Medicine

Towards Targeting PI3K-Dependent Regulation of Gene Expression in Brain Cancer

(2017) Theo Mantamadiotis   Cancers

Phase I/II study with trabedersen (AP 12009) monotherapy for the treatment of patients with advanced pancreatic cancer, malignant melanoma, and colorectal carcinoma.

(2017) H. Oettle et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated fibroblasts in digestive tumors

(2017) Lei Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

JAK-STAT signaling in cancer: From cytokines to non-coding genome

(2016) Jan Pencik et al.   CYTOKINE

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila

(2016) C. S. L. Hoi et al.   GENETICS

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β Signaling in Cancer

(2016) Viqar Syed   JOURNAL OF CELLULAR BIOCHEMISTRY

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Family Signaling in the Control of Cell Proliferation and Survival

(2016) Yun Zhang et al.   Cold Spring Harbor Perspectives in Biology

Regulation of TGF-β Family Signaling by Inhibitory Smads

(2016) Keiji Miyazawa et al.   Cold Spring Harbor Perspectives in Biology

IκB-α: At the crossroad between oncogenic and tumor-suppressive signals

(2016) Alessandro Morotti et al.   Oncology Letters

IKKε and TBK1 expression in gastric cancer

(2016) Seung Eun Lee et al.   Oncotarget

MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4

(2016) Dantong Cheng et al.   Oncotarget

ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation

(2016) Yi Yuan et al.   Oncotarget

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification

(2016) Ling Liu et al.   Scientific Reports

Mechanisms of TGFβ-Induced Epithelial–Mesenchymal Transition

(2016) Aristidis Moustakas et al.   Journal of Clinical Medicine

The Ubiquitination of NF-κB Subunits in the Control of Transcription

(2016) Patricia Collins et al.   Cells

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia

(2015) S. L. Maude et al.   BLOOD

Phase 1 study of galunisertib, a TGF-beta receptor I kinase inhibitor, in Japanese patients with advanced solid tumors

(2015) Yutaka Fujiwara et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

OverAKT3: tumor progression and chemoresistance

(2015) Ping Ji et al.   CELL CYCLE

NFkB is activated by multiple mechanisms in hairy cell leukemia

(2015) Stefan Nagel et al.   GENES CHROMOSOMES & CANCER

Regulation of signal transduction by spatial parameters: a case in NF–κB oscillation

(2015) Kazuhisa Ichikawa et al.   IET Systems Biology

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Structural determinants of Smad function in TGF-β signaling

(2015) Maria J. Macias et al.   TRENDS IN BIOCHEMICAL SCIENCES

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation

(2015) Jason S. L. Yu et al.   Nature Communications

Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway

(2015) Hao Zhang et al.   Oncotarget

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome

(2015) Ana Tufegdzic Vidakovic et al.   Cell Reports

Novel inhibitors are cytotoxic for myeloma cells with NFkB inducing kinase-dependent activation of NFkB

(2015) Yulia N. Demchenko et al.   Oncotarget

TGFβ: A player on multiple fronts in the tumor microenvironment

(2014) Fabian Caja et al.   Journal of Immunotoxicology

Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma

(2014) John C. Morris et al.   PLoS One

Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination

(2014) Feng Xie et al.   Cells

Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy

(2013) Yhun Yhong Sheen et al.   Biomolecules & Therapeutics

Transforming growth factor-β signalling: Role and consequences of Smad linker region phosphorylation

(2013) Danielle Kamato et al.   CELLULAR SIGNALLING

Targeting TGF-β signaling in cancer

(2013) Lior H Katz et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

TGF-β – an excellent servant but a bad master

(2012) Lenka Kubiczkova et al.   Journal of Translational Medicine

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

The secret ally: immunostimulation by anticancer drugs

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

A Novel MMP-2 Inhibitor 3-azidowithaferin A (3-azidoWA) Abrogates Cancer Cell Invasion and Angiogenesis by Modulating Extracellular Par-4

(2012) Bilal Rah et al.   PLoS One

TGF-β/TGF-β receptor system and its role in physiological and pathological conditions

(2011) Juan F. Santibañez et al.   CLINICAL SCIENCE

Alterations in the Smad pathway in human cancers

(2011) Debangshu Samanta   Frontiers in Bioscience-Landmark

Anti-Transforming Growth Factor   Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

(2010) Z. Zhong et al.   CLINICAL CANCER RESEARCH

IKK  controls canonical TGF -SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cells

(2010) M. Brandl et al.   JOURNAL OF CELL SCIENCE

The dynamic roles of TGF-β in cancer

(2010) Erik Meulmeester et al.   JOURNAL OF PATHOLOGY

Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients

(2009) J Nemunaitis et al.   CANCER GENE THERAPY

Increased IκBα expression is essential for the tolerogenic property of TGF-β-exposed APCs

(2009) Paiman Ghafoori et al.   FASEB JOURNAL

Cell Cycle Arrest by Transforming Growth Factor  1 near G1/S Is Mediated by Acute Abrogation of Prereplication Complex Activation Involving an Rb-MCM Interaction

(2009) P. Mukherjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

(2008) Anne Gingery et al.   EXPERIMENTAL CELL RESEARCH

TGF-β induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways

(2008) Charlotte Tacheau et al.   JOURNAL OF CELLULAR PHYSIOLOGY