Article
Immunology
Xiaolong Yan, Xueyan Zhao, Ming Zhou, Yuena Sun, Tianjun Xu
Summary: IRF4b and IRF8 negatively regulate the MITA-mediated NF-kappa B signaling pathway in fish by downregulating MITA expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Tong Zhang, Jianxuan Sun, Jiali Cheng, Wei Yin, Jingwen Li, Heather Miller, Andres A. Herrada, Heng Gu, Hongmei Song, Yan Chen, Quan Gong, Chaohong Liu
Summary: Ubiquitinases are crucial enzymes that modify target proteins through ubiquitination, playing important roles in regulating protein degradation, localization, and function. B lymphocytes differentiate into plasma cells to produce antibodies, participating in humoral immune functions, with ubiquitination playing important roles in B lymphocyte development and function.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Fisheries
Yang Chen, Ya Chen, Xiaolong Yan, Qi Li, Pengfei Wang, Yuena Sun, Tianjun Xu
Summary: This study reveals that hnRNPub inhibits the NF-kappa B signaling pathway by targeting TRAF6, thereby limiting LPS-induced innate activation.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Panpan Hou, Penghui Jia, Kongxiang Yang, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu, Deyin Guo
Summary: The study demonstrates that ASB1 positively regulates inflammatory responses by stabilizing TAB2, leading to protection against septic shock and colitis in mice. This finding sheds light on immune regulation in pathogen infection and inflammatory disorders with therapeutic implications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Xiangqin Kuang, Zhuojun Zhang, Difeng Li, Wenhao Bao, Jinyuan Pan, Ping Zhou, Han Chen, Zhiqing Gao, Xiaoyi Xie, Chunxiao Yang, Ge Zhu, Zhongqiu Zhou, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Xiaoli Feng, Lan Wang, Jianan Yang, Lili Jiang
Summary: In bladder cancer, the downregulation of PI16 is associated with disease progression and poor survival. PI16 inhibits tumor growth and metastasis by suppressing the activation of the NF-kappa B pathway through its interaction with ANXA1. These findings suggest that PI16 may serve as both a tumor suppressor and a potential biomarker for metastatic bladder cancer.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Oncology
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li
Summary: In this study, it was found that overexpression of TRIM47 is associated with tumor progression and poor prognosis in triple-negative breast cancer. The researchers demonstrated that TRIM47 directly interacts with BRCA1 and induces proteasome turnover of BRCA1, leading to a decrease in BRCA1 protein levels in TNBC. Additionally, TRIM47 overexpression confers sensitivity to the PARP inhibitor olaparib, while TRIM47 inhibition confers resistance to olaparib in TNBC. Overexpression of BRCA1 also increases resistance to olaparib in TRIM47-overexpression-induced PARP inhibition sensitivity. These findings suggest that targeting the TRIM47/BRCA1 axis may be a promising prognostic factor and therapeutic target for TNBC.
Review
Cell Biology
Jack Li, Sijin Liu, Shitao Li
Summary: Linear ubiquitination is an important protein modification that attaches a head-to-tail polyubiquitin chain to a substrate protein to mediate signaling pathways. It plays a critical role in various types of cancers, and dysregulation of linear ubiquitination may contribute to tumorigenesis and cancer development.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Virology
Zhili Qu, Yuqin Sun, Xuefeng Zhou, Xiaolong Yan, Tianjun Xu
Summary: This study found that overexpression of Smyd3 facilitates the replication of Siniperca chuatsi rhabdovirus (SCRV) and promotes the degradation of TAK1 protein, thus exerting a negative regulatory effect on the NF-kappa B and IRF3 signaling pathways.
JOURNAL OF VIROLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, the post-translational modification of Tollip by ubiquitination was identified. Tollip interacts with RNF167 and RNF167 functions as the E3 ligase to attach poly-ubiquitin chains to Tollip. The ubiquitination of Tollip plays a crucial role in TNF-alpha signaling.
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Plant Sciences
Tianle Zhan, Baoli Wang, Jiayao Fu, Yanxiong Shao, Lei Ye, Huan Shi, Lingyan Zheng
Summary: The study demonstrated that artesunate (ART) can attenuate BAFF-induced B cell hyperactivation and Sjogren's syndrome (SS)-like symptoms in NOD/Ltj mice. ART inhibited lymphocytic foci formation, B cell infiltration and autoantibody secretion in mice, while also targeting BAFF-activated NF kappa B pathway by regulating TRAF6 degradation to determine B cell survival and proliferation.
Article
Biochemistry & Molecular Biology
Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang
Summary: The study demonstrated that SNX27 inhibits TNF-induced NF-kappa B signaling activation by facilitating the localization of OTULIN to the TNF receptor complex. Additionally, SNX27 interferes with the formation of linear ubiquitin chains mediated by LUBAC, contributing to the inhibition of signaling activation.
CELL AND BIOSCIENCE
(2021)
Review
Immunology
Laura Barnabei, Emmanuel Laplantine, William Mbongo, Frederic Rieux-Laucat, Robert Weil
Summary: NF-kappa B transcription factor plays a crucial role in regulating various aspects of innate and adaptive immune functions, serving as a key mediator of immune homeostasis. It is involved in central and peripheral tolerance, as well as the inactivation and destruction of autoreactive immune cells, contributing to immune tolerance. Furthermore, NF-kappa B plays a role in the pathogenesis of autoimmune diseases and has informed new therapeutic approaches for treating these conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Izaskun Mitxitorena, Elena Saavedra, Carlos Barcia
IMMUNOLOGY AND CELL BIOLOGY
(2015)
Review
Neurosciences
Carlos Barcia, Izaskun Mitxitorena, Maria A. Carrillo-de Sauvage, Jose-Maria Gallego, Ana Perez-Valles, Carlos Barcia
FRONTIERS IN CELLULAR NEUROSCIENCE
(2013)
Article
Multidisciplinary Sciences
Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J. Lindsay, Pier Paolo Pandolfi, Mary W. McCaffrey, Karen Keeshan, Youhai H. Chen, Ruaidhri J. Carmody
SCIENTIFIC REPORTS
(2017)
Article
Medicine, Research & Experimental
Laura R. Diaz, Elena Saavedra-Lopez, Leire Romarate, Izaskun Mitxitorena, Paola Casanova, George P. Cribaro, Jose M. Gallego, Ana Perez-Valles, Jeronimo Forteza-Vila, Clara Alfaro-Cervello, Jose M. Garcia-Verdugo, Carlos Barcia