Review
Cell Biology
Ruben Gomez-Sanchez, Sharon A. Tooze, Fulvio Reggiori
Summary: This review highlights recent advances in understanding the intracellular membrane sources and lipid delivery mechanisms involved in autophagosome biogenesis, emphasizing the importance of vesicular transport and membrane contact sites. Furthermore, it discusses the crucial role of lipid biosynthesis and lipid remodeling events in both phagophore nucleation and expansion.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Review
Plant Sciences
Linhui Yu, Chao Zhou, Jilian Fan, John Shanklin, Changcheng Xu
Summary: Lipid remodeling, defined as post-synthetic modifications of membrane lipids, plays a crucial role in regulating cellular membrane properties and functions. Processes affected by lipid remodeling include lipid metabolism, membrane repair, cellular homeostasis, fatty acid trafficking, cellular signaling, and stress tolerance. Recent research focuses on understanding the mechanisms of membrane lipid remodeling, particularly the enzymes involved in modifying major membrane lipids such as phosphatidylcholine and monogalactosyldiacylglycerol.
Article
Biochemistry & Molecular Biology
Mike F. Renne, Xue Bao, Margriet W. J. Hokken, Adolf S. Bierhuizen, Martin Hermansson, Richard R. Sprenger, Tom A. Ewing, Xiao Ma, Ruud C. Cox, Jos F. Brouwers, Cedric H. De Smet, Christer S. Ejsing, Anton I. P. M. de Kroon
Summary: Our study reveals the importance of ERMES and Vps39p in mediating the transfer of di-unsaturated phospholipids to mitochondria. This supports the concept that lipid flow between membranes is limited by molecular species-dependent lipid efflux and concentration gradients between membranes.
Article
Biochemistry & Molecular Biology
Laidy M. Alvero-Gonzalez, D. Aurora Perini, Maria Queralt-Martin, Alex Peralvarez-Marin, Clara Vinas, Antonio Alcaraz
Summary: DynA is an endogenous neuropeptide that has non-opioid pathophysiological properties and can induce cell permeability similar to cell-penetrating peptides. The interaction of DynA with cellular membrane is modulated by lipid charge distribution, enabling passive ionic transport via membrane remodeling and pore formation, as well as peptide direct internalization independent of cellular transduction pathways.
BIOELECTROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Johanna Ude, Vishwachi Tripathi, Julien M. Buyck, Sandra Soderholm, Olivier Cunrath, Joseph Fanous, Beatrice Claudi, Adrian Egli, Christian Schleberger, Sebastian Hiller, Dirk Bumann
Summary: This study found that all porins in Pseudomonas aeruginosa were not essential for bacterial growth in rich medium and consumption of diverse hydrophilic nutrients. However, nutrients with multiple carboxylate groups permeated poorly in the absence of porins. Porins provided efficient pathways for nutrient uptake while effectively excluding most antibiotics except carbapenems, with outer-membrane lipid bilayer serving as a major pathway for nutrient and drug entry into the bacterial cell.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Varnavas D. Mouchlis, Daiki Hayashi, Alexis M. Vasquez, Jian Cao, J. Andrew McCammon, Edward A. Dennis
Summary: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) associates with lipoproteins in human plasma and hydrolyzes oxidized phospholipids. The mechanism of enzyme-membrane association and substrate specificity were studied using lipidomics and mass spectrometry techniques.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Sanjoy Paul, Anjon Audhya, Qiang Cui
Summary: The Sar1 GTPase plays a key role in COPII-mediated protein transport by generating membrane curvature on the endoplasmic reticulum. However, the molecular mechanism by which Sar1 is activated and regulates membrane remodeling remains unclear. Using molecular dynamics simulations, we show that Sar1-GTP inserts into the membrane more efficiently and generates higher positive curvature compared to Sar1-GDP. Dimerization of Sar1-GTP further amplifies curvature generation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Physiology
Yucan Dai, Haiqing Tang, Shanshan Pang
Summary: Phospholipids, as major membrane lipids, play important roles in protecting cells, promoting cellular processes, and are linked to signal transductions, organelle functions, physiological processes, and human diseases. Recent studies have shown crucial roles of membrane lipids in the aging process, with investigations on changing patterns of phospholipid species with age and their functions in regulating healthspan and lifespan. This advances our understanding of the relationship between membrane lipids and aging.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Colin Brownlee, Katherine E. Helliwell, Yasmin Meeda, Deirdre McLachlan, Eleanor A. Murphy, Glen L. Wheeler
Summary: Diatoms are highly successful marine phytoplankton and play a crucial role in ocean biogeochemical cycling. They inhabit various marine, freshwater, and ice environments across the globe. Their success is attributed to their ability to regulate growth and metabolism in response to nutrient availability. This review highlights the transport mechanisms involved in nutrient acquisition (N, C, P, Si, Fe) by marine diatoms, emphasizing their complexity, sophistication, and multi-level control.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Yagmur Azbazdar, Mustafa Karabicici, Esra Erdal, Gunes Ozhan
Summary: Wnt signaling pathway plays a crucial role in physiological activities and has significant implications in cancer development and progression. By regulating plasma membrane composition and lipid organization, Wnt signaling can be activated or inhibited, leading to the development of more targeted anticancer drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ian J. Roney, David Z. Rudner
Summary: Sorting of phospholipids between membrane bilayers is a fundamental problem, and the enzymes that catalyze phospholipid reorientation in bacteria remain unknown. Members of the DedA superfamily have been implicated in lipid carrier transport and lipid scrambling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Yasuo Yamazaki, Yuka Eura, Koichi Kokame
Summary: V0a1 is identified as a crucial factor for membrane fission of Weibel-Palade bodies (WPBs) in vascular endothelial cells, while protein kinase D (PKD) is found to be essential for WPB biogenesis. The discovery of V0a1 as a new membrane fission regulator is expected to improve understanding of the molecular events enabling membrane fission.
Article
Agronomy
Shengnan Ge, Debin Liu, Min Chu, Xinyu Liu, Yulei Wei, Xinyang Che, Lei Zhu, Lin He, Jingyu Xu
Summary: This study investigated the changes in membrane lipids in sorghum leaves under salt stress. Salt stress increased the content of phospholipids in sorghum leaves while decreasing the proportion of MGDG and PG. The adjustment of glycerolipid pathways between the cytosolic and plastidic compartments was triggered by salt stress.
Article
Biochemistry & Molecular Biology
Sungmin Shin, Hyunhyuk Tae, Soohyun Park, Nam-Joon Cho
Summary: Antimicrobial fatty acids derived from natural sources and renewable feedstocks are a promising surface-active substance with a wide range of applications. Their ability to target bacterial membrane in multiple mechanisms offers a promising antimicrobial approach. However, the interaction and destabilization of bacterial cell membranes by these compounds are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chinta M. Aryal, Nhat Nguyen Bui, Likai Song, Jianjun Pan
Summary: This study investigates the membrane interactions of the helix 0 of amphiphysin (H0-Amph) and endophilin (H0-Endo) and their effects on membrane properties. It was found that H0-Amph reduces lipid mobility, increases membrane polarity, and decreases lipid chain orientational order. H0-Endo acts as a more potent modulator in anionic membranes. Atomic force microscopy revealed membrane structural changes induced by both peptides, with only H0-Amph inducing membrane fusion. These findings contribute to our understanding of membrane curvature regulation mechanisms.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
