Cancer-associated fibroblasts in digestive tumors

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis

(2014) M. Berdiel-Acer et al.   MOLECULAR CANCER RESEARCH

Carcinoma-associated fibroblasts provide operational flexibility in metastasis

(2014) Olivier De Wever et al.   SEMINARS IN CANCER BIOLOGY

miR-205 Hinders the Malignant Interplay Between Prostate Cancer Cells and Associated Fibroblasts

(2013) Paolo Gandellini et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

FGFR4 Promotes Stroma-Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer

(2013) R. Liu et al.   CANCER RESEARCH

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell Carcinoma

(2013) Daniela Elena Costea et al.   CANCER RESEARCH

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

(2013) Xiang H.-F. Zhang et al.   CELL

Progastrin-Induced Secretion of Insulin-Like Growth Factor 2 From Colonic Myofibroblasts Stimulates Colonic Epithelial Proliferation in Mice

(2013) Carrie A. Duckworth et al.   GASTROENTEROLOGY

Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis

(2013) Xin-Long Yan et al.   HEPATOLOGY

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver

(2013) Chunsheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity

(2013) Tuanjie Li et al.   MEDICAL ONCOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion

(2013) Chang-Chang Jia et al.   PLoS One

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors

(2013) Z. Castano et al.   Cancer Discovery

Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model

(2013) Falk Saupe et al.   Cell Reports

The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial

(2012) A. Huijbers et al.   ANNALS OF ONCOLOGY

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer

(2012) C. Pena et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling

(2012) Astrid De Boeck et al.   GUT

Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis*

(2012) Lei Zhao et al.   HEPATOLOGY

Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

(2012) Pallavi Chaturvedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2

(2012) Sonia Alcolea et al.   JOURNAL OF LIPID RESEARCH

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

GSTPi-positive tumour microenvironment-associated fibroblasts are significantly associated with GSTPi-negative cancer cells in paired cases of primary invasive breast cancer and axillary lymph node metastases

(2011) B Chaiwun et al.   BRITISH JOURNAL OF CANCER

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Role for Stromal Heterogeneity in Prostate Tumorigenesis

(2011) M. A. Kiskowski et al.   CANCER RESEARCH

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis

(2011) Zhiyong Mi et al.   CARCINOGENESIS

Discoidin domain receptor 2 deficiency predisposes hepatic tissue to colon carcinoma metastasis

(2011) Iker Badiola et al.   GUT

Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/ -catenin signalling pathway

(2011) L. Fu et al.   GUT

Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts

(2011) Antonio Mazzocca et al.   HEPATOLOGY

Sorafenib Inhibits the Hepatocyte Growth Factor-Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma

(2011) T. Nagai et al.   MOLECULAR CANCER THERAPEUTICS

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells

(2010) C.-P. Liao et al.   CANCER RESEARCH

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

(2010) Roy-Akira Saito et al.   CANCER RESEARCH

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts

(2010) K. Walter et al.   CLINICAL CANCER RESEARCH

Amelioration of hepatic fibrosis by NK cell activation

(2010) N. Muhanna et al.   GUT

p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways

(2010) Jing Fu et al.   HEPATOLOGY

Mesenchymal stem cells enhance growth and metastasis of colon cancer

(2010) Kei Shinagawa et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma

(2010) Marilena Vered et al.   INTERNATIONAL JOURNAL OF CANCER

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial-mesenchymal transition-like state in breast cancer cells in vitro

(2010) M.-Q. Gao et al.   JOURNAL OF CELL SCIENCE

CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients

(2010) Leilei Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma

(2010) Dong-Ming Kuang et al.   JOURNAL OF HEPATOLOGY

Reciprocal Functional Modulation of the Activation of T Lymphocytes and Fibroblasts Derived from Human Solid Tumors

(2010) J. L. Barnas et al.   JOURNAL OF IMMUNOLOGY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

(2010) K. D. Grugan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment

(2009) Yongping Crawford et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells

(2009) Dong-Ming Kuang et al.   HEPATOLOGY

The invasive potential of human melanoma cell lines correlates with their ability to alter fibroblast gene expressionin vitroand the stromal microenvironmentin vivo

(2009) Ling Li et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7

(2009) Da-Woon Jung et al.   INTERNATIONAL JOURNAL OF CANCER

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease

(2009) Hervé Acloque et al.   JOURNAL OF CLINICAL INVESTIGATION

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Responsiveness of Stromal Fibroblasts to IFN-  Blocks Tumor Growth via Angiostasis

(2009) Y. Lu et al.   JOURNAL OF IMMUNOLOGY

Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells

(2009) X. Su et al.   JOURNAL OF IMMUNOLOGY

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer associated fibroblasts in cancer pathogenesis

(2009) Omar E. Franco et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?

(2009) Tamas A. Gonda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Outcomes after radiotherapy for basaloid squamous cell carcinoma of the head and neck

(2008) Juliette Thariat et al.   CANCER

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

(2008) L. Jiang et al.   CANCER RESEARCH

Breast Carcinoma-Associated Fibroblasts and Their Counterparts Display Neoplastic-Specific Changes

(2008) N. M. Hawsawi et al.   CANCER RESEARCH

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Breast Cancer-Associated Fibroblasts Confer AKT1-Mediated Epigenetic Silencing of Cystatin M in Epithelial Cells

(2008) H.-J. L. Lin et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis

(2008) Sebastián Giulianelli et al.   INTERNATIONAL JOURNAL OF CANCER

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

(2008) Cornelia Liedtke et al.   JOURNAL OF CLINICAL ONCOLOGY

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas

(2008) Wen Qiu et al.   NATURE GENETICS

CANCER BIOLOGY: All in the Stroma: Cancer's Cosa Nostra

(2008) J. Marx   SCIENCE

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

(2008) Kristian Pietras et al.   PLOS MEDICINE