Review
Gastroenterology & Hepatology
Eduardo E. E. Montalvo-Jave, Natalia Nuno-Lambarri, Guillermo Nahum Lopez-Sanchez, Edwin A. A. Ayala-Moreno, Gabriela Gutierrez-Reyes, Joal Beane, Timothy M. M. Pawlik
Summary: Pancreatic cancer is a lethal disease driven by multiple genetic and epigenetic alterations. Advances in microarray and omics-based sequencing techniques have led to the discovery of novel disease markers, prognostic factors, and therapeutic targets for pancreatic ductal adenocarcinoma (PDAC).
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Oncology
Shanshan Liu, Qiuyue Li, Yan Ma, Christopher Corpe, Jin Wang
Summary: The article mainly introduces the biogenesis, characteristics, and roles of circRNAs in cancer regulation, as well as their potential as novel biomarkers and therapeutic targets in pancreatic cancer.
Article
Gastroenterology & Hepatology
Ylenia Nodari, Manuel Gentiluomo, Beatrice Mohelnikova-Duchonova, Edita Kreivenaite, Anna Caterina Milanetto, Jurgita Skieceviciene, Stefano Landi, Rita Lawlor, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Martin Lovecek, Maria Gazouli, Maarten F. Bijlsma, Luca Morelli, Vytautas Kiudelis, Matteo Tacelli, Dalila Luciola Zanette, Pavel Soucek Kaaks, Faik Uzunoglu, Rudolf Kaaks, Jakob Izbicki, Ugo Boggi, Raffaele Pezzilli, Andrea Mambrini, Claudio Pasquali, Hanneke W. van Laarhove, Verena Katzke, Giulia Martina Cavestro, Cosimo Sperti, Martin Loos, Anna Latiano, Balint Eross, Martin Oliverius, Theron Johnson, Daniela Basso, John P. Neoptolemos, Mateus Nobrega Aoki, William Greenhalf, Pavel Vodick, Livia Archibugi, Giuseppe Vanella, Maurizio Lucchesi, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Mohammed Al Saeedi, Casper H. J. van Eijck, Juozas Kupcinskas, Tamas Hussein, Marta Puzzono, Stefania Bunduc, Mara Gotz, Silvia Carrara, Andrea Szentesi, Francesca Tavano, Stefania Moz, Peter Hegyi, Claudio Luchini, Gabriele Capurso, Francesco Perri, Stefano Ermini, George Theodoropoulos, Giovanni Capretti, Orazio Palmieri, Laura Ginocchi, Niccolo Furbetta, Federico Canzian, Daniele Campa
Summary: This study found that established risk factors for pancreatic cancer may not have a strong age-related effect on early-onset pancreatic cancer (EOPC) patients. Furthermore, smoking and diabetes play important roles in EOPC.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Stefan Harsanyi, Zuzana Varchulova Novakova, Katarina Bevizova, Lubos Danisovic, Stanislav Ziaran
Summary: Bladder cancer is the 10th most common cancer worldwide, with a variety of diagnostic methods available, including standard cystoscopy and urine cytology. Liquid biopsy as a new trend is proving to be almost equally effective in detecting bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Valentina Ferradini, Davide Vacca, Beatrice Belmonte, Ruggiero Mango, Letizia Scola, Giuseppe Novelli, Carmela Rita Balistreri, Federica Sangiuolo
Summary: Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a rare pathology with individual heterogeneity, predominantly affecting postmenopausal women. While a genetic basis in TTS pathogenesis is suspected, clear evidence is lacking. Further research is needed to understand the pathophysiology of TTS and to identify specific and effective treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Anastasia P. Koval, Konstantin A. Blagodatskikh, Nikolay E. Kushlinskii, Dmitry S. Shcherbo
Summary: Nucleic acid fragments in blood circulation come from dying cells and carry indicators of the parental cell types. While progress has been made in detecting sequence alterations in cell-free DNA, decoding epigenetic information from methylation and fragmentation patterns requires more sophisticated approaches.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Akash Bararia, Prosenjeet Chakraborty, Paromita Roy, Bitan Kumar Chattopadhay, Amlan Das, Aniruddha Chatterjee, Nilabja Sikdar
Summary: There is a global increase in the incidence of pancreatic cancer, which poses a major health concern. Traditional diagnostic techniques based on tissue have limitations in terms of diagnosis difficulties and tissue availability. Cell free markers have the potential to discriminate pancreatic cancer from other diseases and precancerous lesions. Non-invasive disease detection approaches are gaining popularity due to their early-stage diagnostic capability and clinical feasibility.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ying Xu, Qing Zhu
Summary: Pancreatic cancer is a lethal disease characterized by high invasiveness, early metastasis, rapid progression, and late diagnosis. The ability of pancreatic cancer cells to undergo EMT plays a crucial role in their tumorigenic and metastatic potential, as well as therapeutic resistance. Histone modifications, a central epigenetic modification, are closely involved in EMT. In this review, we discuss the mechanisms by which histone-modifying enzymes regulate EMT in pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jinshou Yang, Bo Ren, Jie Ren, Gang Yang, Yuan Fang, Xing Wang, Feihan Zhou, Lei You, Yupei Zhao
Summary: Metabolic remodelling and epigenetic reprogramming play important roles in PDAC tumorigenesis and metastasis. This study focused on guanidinoacetic acid (GAA) and revealed its association with PDAC liver metastasis through the GAA-c-Myc-HMGA axis and transcription-activating histone modifications reprogramming.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Melissa C. Southey, Pierre-Antoine Dugue
Summary: In the past decade, advancements in breast cancer risk prediction models have mainly come from new insights into genetic risk factors and improvements in mammogram-based risk scores. Epigenetic risk factors hold potential for further enhancing risk stratification; however, the recently developed DNA methylation score (the WID-BC index) is not yet convincing for predicting breast cancer risk.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Jamie R. Johnston, Daniel F. Selgrade, Elizabeth M. McNally
Summary: Mutations in the LMNA gene are a common cause of adult-onset cardiomyopathy and heart failure, with a prenatal feature of impaired cardiomyocyte development and maturation identified in a Laminopathy model. Treatment of the LMNA H222P mouse model improved congenital cardiomyopathy and increased survival in utero, presenting a unique therapeutic strategy for cardiomyopathy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Gastroenterology & Hepatology
Alison P. Klein
Summary: Pancreatic cancer is a leading cause of cancer death globally, with significant risk factors including smoking, obesity, diabetes, and genetic factors. Efforts to understand and address these modifiable and inherited risk factors are crucial for early detection and prevention strategies for pancreatic cancer.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Jiangfan Yu, Rui Tang, Ke Ding
Summary: Systemic sclerosis is a rare chronic autoimmune disease that involves genetic and environmental factors, as well as the influence of epigenetic regulation.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sarah S. Wang, Jihao Xu, Keely Y. Ji, Chang-Il Hwang
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a significant cause of cancer-related deaths in the United States. While genetic mutations driving PDA initiation and progression have been identified, the mechanisms underlying PDA metastasis remain elusive. It is suggested that epigenetic fluctuations may play a critical role in driving PDA metastasis.
Review
Cell Biology
Daniel J. Zabransky, Elizabeth M. Jaffee, Ashani T. Weeraratna
Summary: This review provides a detailed discussion on the genetic and epigenetic changes associated with normal aging and the mechanisms responsible for these changes. By highlighting the genetic and epigenetic alterations in the context of tumorigenesis, cancer progression, and the aging tumor microenvironment, it explores the possible impacts of the normal aging process on malignant transformation. Furthermore, it examines the implications of age-related genetic and epigenetic alterations in both tumors and patients for cancer treatment.
TRENDS IN CELL BIOLOGY
(2022)