Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
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Title
Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
Authors
Keywords
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Journal
Nature Communications
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-04-20
DOI
10.1038/s41467-022-29506-y
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Note: Only part of the references are listed.- Nebulosa recovers single-cell gene expression signals by kernel density estimation
- (2021) Jose Alquicira-Hernandez et al. BIOINFORMATICS
- Restoring metabolism of myeloid cells reverses cognitive decline in ageing
- (2021) Paras S. Minhas et al. NATURE
- Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
- (2020) Annerieke Sierksma et al. EMBO Molecular Medicine
- Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain
- (2020) Jeroen F.J. Bogie et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- SciBet as a portable and fast single cell type identifier
- (2020) Chenwei Li et al. Nature Communications
- A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α ‐Synuclein Mice
- (2020) Silke Nuber et al. ANNALS OF NEUROLOGY
- Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
- (2020) Yun Chen et al. NEURON
- Pharmacokinetics of Supplemental Omega-3 Fatty Acids Esterified in Monoglycerides, Ethyl Esters, or Triglycerides in Adults in a Randomized Crossover Trial
- (2020) Laurie Chevalier et al. JOURNAL OF NUTRITION
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- A comparison of single-cell trajectory inference methods
- (2019) Wouter Saelens et al. NATURE BIOTECHNOLOGY
- The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
- (2019) Carlo Sala Frigerio et al. Cell Reports
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease
- (2019) Sung Hoon Baik et al. Cell Metabolism
- The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
- (2019) Adiv A. Johnson et al. AGING CELL
- Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase
- (2019) Thibaut Imberdis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
- (2019) Tiffany Wu et al. Cell Reports
- Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
- (2019) Anne-Laure Hemonnot et al. Frontiers in Aging Neuroscience
- Stem-cell-derived human microglia transplanted in mouse brain to study human disease
- (2019) Renzo Mancuso et al. NATURE NEUROSCIENCE
- Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
- (2019) Elizabeth Spangenberg et al. Nature Communications
- ShinyGO: a graphical gene-set enrichment tool for animals and plants
- (2019) Steven Xijin Ge et al. BIOINFORMATICS
- Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
- (2018) Kelly Street et al. BMC GENOMICS
- Mapping the Mouse Cell Atlas by Microwell-Seq
- (2018) Xiaoping Han et al. CELL
- Microglia-Mediated Synapse Loss in Alzheimer's Disease
- (2018) Lawrence Rajendran et al. JOURNAL OF NEUROSCIENCE
- Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
- (2018) Justyna Sosna et al. Molecular Neurodegeneration
- Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
- (2018) Brad A. Friedman et al. Cell Reports
- Plasma and Brain Fatty Acid Profiles in Mild Cognitive Impairment and Alzheimer's Disease
- (2018) Stephen C. Cunnane et al. JOURNAL OF ALZHEIMERS DISEASE
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
- (2018) Saranna Fanning et al. MOLECULAR CELL
- Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity
- (2018) Benjamin M. Vincent et al. Cell Reports
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
- (2017) Qiaoqiao Shi et al. Science Translational Medicine
- Synaptic Impairment in Alzheimer’s Disease: A Dysregulated Symphony
- (2017) Stefania Forner et al. TRENDS IN NEUROSCIENCES
- Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability
- (2016) Martijn C. de Wilde et al. Alzheimers & Dementia
- Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology
- (2016) Elizabeth E. Spangenberg et al. BRAIN
- Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study
- (2016) Pratishtha Chatterjee et al. JOURNAL OF ALZHEIMERS DISEASE
- Wishbone identifies bifurcating developmental trajectories from single-cell data
- (2016) Manu Setty et al. NATURE BIOTECHNOLOGY
- Microglia development follows a stepwise program to regulate brain homeostasis
- (2016) O. Matcovitch-Natan et al. SCIENCE
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease
- (2015) Laura K. Hamilton et al. Cell Stem Cell
- Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice
- (2015) Nabil N. Dagher et al. Journal of Neuroinflammation
- Genetics ignite focus on microglial inflammation in Alzheimer’s disease
- (2015) Manasi Malik et al. Molecular Neurodegeneration
- HISAT: a fast spliced aligner with low memory requirements
- (2015) Daehwan Kim et al. NATURE METHODS
- Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals
- (2014) Mélanie Plourde et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Synapse elimination and learning rules co-regulated by MHC class I H2-Db
- (2014) Hanmi Lee et al. NATURE
- Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis
- (2014) D. C. Ryman et al. NEUROLOGY
- Untangling the Influences of Voluntary Running, Environmental Complexity, Social Housing and Stress on Adult Hippocampal Neurogenesis
- (2014) Catherine-Alexandra Grégoire et al. PLoS One
- TCC: an R package for comparing tag count data with robust normalization strategies
- (2013) Jianqiang Sun et al. BMC BIOINFORMATICS
- MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression
- (2013) P. A. Nelson et al. LEARNING & MEMORY
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases
- (2013) Bai Lu et al. NATURE REVIEWS NEUROSCIENCE
- Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer’s disease
- (2012) Jonny Daborg et al. JOURNAL OF NEURAL TRANSMISSION
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Age-related changes in neuroactive steroid levels in 3xTg-AD mice
- (2012) Donatella Caruso et al. NEUROBIOLOGY OF AGING
- Synapses and Alzheimer's Disease
- (2012) M. Sheng et al. Cold Spring Harbor Perspectives in Biology
- Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain
- (2011) S. Snigdha et al. NEUROSCIENCE
- Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease
- (2011) Giuseppe Astarita et al. PLoS One
- Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
- (2011) R. C. Paolicelli et al. SCIENCE
- Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease
- (2010) Laura K. Hamilton et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Homer 1a Gates the Induction Mechanism for Endocannabinoid-Mediated Synaptic Plasticity
- (2010) A. M. Roloff et al. JOURNAL OF NEUROSCIENCE
- Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
- (2010) Michael C Chang et al. NATURE NEUROSCIENCE
- Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
- (2009) Stefan A Grathwohl et al. NATURE NEUROSCIENCE
- Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease
- (2009) Thomas Fraser et al. NEUROCHEMICAL RESEARCH
- Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
- (2009) Akash Datwani et al. NEURON
- Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
- (2008) Matthew T Flowers et al. CURRENT OPINION IN LIPIDOLOGY
- Eicosapentaenoic acid decreases postprandial β-hydroxybutyrate and free fatty acid responses in healthy young and elderly
- (2008) Mélanie Plourde et al. NUTRITION
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