A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α ‐Synuclein Mice
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A Stearoyl–Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in
α
‐Synuclein Mice
Authors
Keywords
-
Journal
ANNALS OF NEUROLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-09-30
DOI
10.1002/ana.25920
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity
- (2019) Matteo Rovere et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes
- (2019) Sarah H. Shahmoradian et al. NATURE NEUROSCIENCE
- And three’s a party: lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis
- (2019) Mike Henne CURRENT OPINION IN CELL BIOLOGY
- Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice
- (2019) Molly M. Rajsombath et al. JOURNAL OF NEUROSCIENCE
- Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase
- (2019) Thibaut Imberdis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein
- (2018) Emma I. O'Leary et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies
- (2018) Vedad Delic et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Pathological role of lipid interaction with α-synuclein in Parkinson's disease
- (2018) Mari Suzuki et al. NEUROCHEMISTRY INTERNATIONAL
- Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease
- (2018) Mélanie Bourque et al. NEUROPHARMACOLOGY
- Octanoic acid prevents reduction of striatal dopamine in the MPTP mouse model of Parkinson's disease.
- (2018) Ilona Joniec-Maciejak et al. Pharmacological Reports
- GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
- (2018) Sangjune Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Isolation of recombinant tetrameric N-acetylated α-synuclein
- (2018) Ricardo D. Fernández et al. PROTEIN EXPRESSION AND PURIFICATION
- Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
- (2018) Saranna Fanning et al. MOLECULAR CELL
- Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease
- (2018) Silke Nuber et al. NEURON
- Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity
- (2018) Benjamin M. Vincent et al. Cell Reports
- Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells
- (2017) Ulf Dettmer et al. HUMAN MOLECULAR GENETICS
- Hair Growth Cycle Is Arrested in SCD1 Deficiency by Impaired Wnt3a-Palmitoleoylation and Retrieved by the Artificial Lipid Barrier
- (2017) Wilhelm Stoffel et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Stearic Acid Supplementation in High Protein to Carbohydrate (P:C) Ratio Diet Improves Physiological and Mitochondrial Functions of Drosophila melanogaster parkin Null Mutants
- (2017) Rijan Bajracharya et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- α-Synuclein promotes dilation of the exocytotic fusion pore
- (2017) Todd Logan et al. NATURE NEUROSCIENCE
- New insights into cellular α-synuclein homeostasis in health and disease
- (2016) Ulf Dettmer et al. CURRENT OPINION IN NEUROBIOLOGY
- Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges
- (2016) Lauren R. Kett et al. MOVEMENT DISORDERS
- Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
- (2016) Maria Xilouri et al. MOVEMENT DISORDERS
- Morphologically and Functionally Distinct Lipid Droplet Subpopulations
- (2016) Shuyan Zhang et al. Scientific Reports
- Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition
- (2015) Simon Sebastian Raesch et al. ACS Nano
- Regulation of mitochondrial morphology and function by stearoylation of TFR1
- (2015) Deniz Senyilmaz et al. NATURE
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Total and Proteinase K-Resistant α-Synuclein Levels in Erythrocytes, Determined by their Ability to Bind Phospholipids, Associate with Parkinson’s Disease
- (2015) Suaad Abd-Elhadi et al. Scientific Reports
- α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
- (2014) Lina Wang et al. CURRENT BIOLOGY
- Pharmacology of dimethyl sulfoxide in cardiac and CNS damage
- (2014) Stanley W. Jacob et al. Pharmacological Reports
- Structures of the E46K Mutant-Type α-Synuclein Protein and Impact of E46K Mutation on the Structures of the Wild-Type α-Synuclein Protein
- (2013) Olivia Wise-Scira et al. ACS Chemical Neuroscience
- A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats
- (2013) Silke Nuber et al. BRAIN
- In VivoCross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells
- (2013) Ulf Dettmer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Properties of native brain α-synuclein
- (2013) Jacqueline Burré et al. NATURE
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- Monomeric Synucleins Generate Membrane Curvature
- (2012) Christopher H. Westphal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein
- (2012) Adam J. Trexler et al. PROTEIN SCIENCE
- N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors
- (2011) Karen A. Atkinson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
- (2011) Frank Soldner et al. CELL
- Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase
- (2011) Natalie Krahmer et al. Cell Metabolism
- Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae
- (2011) N. Jacquier et al. JOURNAL OF CELL SCIENCE
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- A soluble -synuclein construct forms a dynamic tetramer
- (2011) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More