Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo

Aspiration-assisted bioprinting for precise positioning of biologics

(2020) Bugra Ayan et al.   Science Advances

Sensing tissue engineered cartilage quality with Raman spectroscopy and statistical learning for the development of advanced characterization assays

(2020) Laura J. Power et al.   BIOSENSORS & BIOELECTRONICS

Collagen I-based scaffolds negatively impact fracture healing in a mouse-osteotomy-model although used routinely in research and clinical application

(2019) Annemarie Lang et al.   Acta Biomaterialia

Reduction of BMP6‐induced bone formation by calcium phosphate in wild‐type compared with nude mice

(2019) Hiroki Katagiri et al.   Journal of Tissue Engineering and Regenerative Medicine

Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers

(2019) Andrew C. Daly et al.   BIOMATERIALS

Grow with the Flow: When Morphogenesis Meets Microfluidics

(2019) Pinak Samal et al.   ADVANCED MATERIALS

Retinoic-acid-induced osteogenesis of hiPSCs

(2019) Christina Jacobsen et al.   Nature Biomedical Engineering

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

(2019) Hiroyuki Koike et al.   NATURE

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels

(2019) Mark A. Skylar-Scott et al.   Science Advances

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway

(2019) Solvig Diederichs et al.   Frontiers in Cell and Developmental Biology

Investigation of multiphasic 3D‐bioplotted scaffolds for site‐specific chondrogenic and osteogenic differentiation of human adipose‐derived stem cells for osteochondral tissue engineering applications

(2019) Liliana F. Mellor et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

(2019) Gabriella Nilsson Hall et al.   Advanced Science

Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

(2019) Zixuan Lin et al.   Frontiers in Bioengineering and Biotechnology

Spatially confined induction of endochondral ossification by functionalized hydrogels for ectopic engineering of osteochondral tissues

(2018) Chiara Stüdle et al.   BIOMATERIALS

High-throughput image-based monitoring of cell aggregation and microspheroid formation

(2018) Thomas Deckers et al.   PLoS One

Developmentally inspired programming of adult human mesenchymal stromal cells toward stable chondrogenesis

(2018) Paola Occhetta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advancing osteochondral tissue engineering: bone morphogenetic protein, transforming growth factor, and fibroblast growth factor signaling drive ordered differentiation of periosteal cells resulting in stable cartilage and bone formation in vivo

(2018) L. F. Mendes et al.   Stem Cell Research & Therapy

Osteochondral Lesions of the Knee: Differentiating the Most Common Entities at MRI

(2018) Tetyana Gorbachova et al.   RADIOGRAPHICS

Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation

(2018) Pieter-Jan Stiers et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regeneration of Osteochondral Defects Using Developmentally Inspired Cartilaginous Templates

(2018) Susan Critchley et al.   TISSUE ENGINEERING PART A

Ectopic implantation of juvenile osteochondral tissues recapitulates endochondral ossification

(2017) Johnathan Ng et al.   Journal of Tissue Engineering and Regenerative Medicine

No superior surgical treatment for secondary osteochondral defects of the talus

(2017) Kaj T. A. Lambers et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects: the importance of long-term studies in a large animal model

(2017) R.A. Vindas Bolaños et al.   OSTEOARTHRITIS AND CARTILAGE

Incidence of symptomatic osteochondritis dissecans lesions of the knee: a population-based study in Olmsted County

(2017) A. Pareek et al.   OSTEOARTHRITIS AND CARTILAGE

Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage

(2017) Johnathan J. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Articular cartilage and joint development from embryogenesis to adulthood

(2017) Rebekah S. Decker   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells

(2016) Luis Filipe Mendes et al.   TISSUE ENGINEERING PART C-METHODS

Tuning Cell Differentiation into a 3D Scaffold Presenting a Pore Shape Gradient for Osteochondral Regeneration

(2016) Andrea Di Luca et al.   Advanced Healthcare Materials

Systematic Reconstruction of Molecular Cascades Regulating GP Development Using Single-Cell RNA-Seq

(2016) Junxiang Li et al.   Cell Reports

Joint Development Involves a Continuous Influx of Gdf5-Positive Cells

(2016) Yulia Shwartz et al.   Cell Reports

Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage

(2016) Mads S. Bergholt et al.   ACS Central Science

Bioinspired seeding of biomaterials using three dimensional microtissues induces chondrogenic stem cell differentiation and cartilage formation under growth factor free conditions

(2016) J. Leijten et al.   Scientific Reports

Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles

(2015) Jetze Visser et al.   BIOMATERIALS

High-throughput bone and cartilage micropellet manufacture, followed by assembly of micropellets into biphasic osteochondral tissue

(2015) Betul Kul Babur et al.   CELL AND TISSUE RESEARCH

Challenges in engineering osteochondral tissue grafts with hierarchical structures

(2015) Ivana Gadjanski et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Generation of articular chondrocytes from human pluripotent stem cells

(2015) April M Craft et al.   NATURE BIOTECHNOLOGY

Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells

(2015) W.D. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

(2015) Akihiro Yamashita et al.   Stem Cell Reports

Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation

(2014) S. Bhumiratana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vibrational Spectroscopic Imaging for the Evaluation of Matrix and Mineral Chemistry

(2014) S. Gamsjaeger et al.   Current Osteoporosis Reports

A histological comparison of the repair tissue formed when using either Chondrogide® or periosteum during autologous chondrocyte implantation

(2013) H.S. McCarthy et al.   OSTEOARTHRITIS AND CARTILAGE

The Impact of Compact Layer in Biphasic Scaffold on Osteochondral Tissue Engineering

(2013) Hu Da et al.   PLoS One

Engineering of a functional bone organ through endochondral ossification

(2013) C. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering bone tissue substitutes from human induced pluripotent stem cells

(2013) G. M. de Peppo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contrast-Enhanced Nanofocus X-Ray Computed Tomography Allows Virtual Three-Dimensional Histopathology and Morphometric Analysis of Osteoarthritis in Small Animal Models

(2013) Greet Kerckhofs et al.   Cartilage

Engineering osteochondral constructs through spatial regulation of endochondral ossification

(2012) Eamon J. Sheehy et al.   Acta Biomaterialia

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

(2012) J. C. H. Leijten et al.   ARTHRITIS AND RHEUMATISM

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

In-vivo generation of bone via endochondral ossification by in-vitro chondrogenic priming of adult human and rat mesenchymal stem cells

(2011) Eric Farrell et al.   BMC MUSCULOSKELETAL DISORDERS

An Emerging Paradigm in Tissue Engineering: From Chemical Engineering to Developmental Engineering for Bioartificial Tissue Formation through a Series of Unit Operations that Simulate the In Vivo Successive Developmental Stages†

(2011) Petros Lenas et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification

(2011) E J Mackie et al.   JOURNAL OF ENDOCRINOLOGY

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Clinical Efficacy of the Microfracture Technique for Articular Cartilage Repair in the Knee

(2009) Kai Mithoefer et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling

(2009) J. Eyckmans et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Developmental Engineering: A New Paradigm for the Design and Manufacturing of Cell-Based Products. Part I: From Three-Dimensional Cell Growth to Biomimetics of In Vivo Development

(2009) Petros Lenas et al.   TISSUE ENGINEERING PART B-REVIEWS