3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

(2020) Maria-Patapia Zafeiriou et al.   Nature Communications

Modulating electrophysiology of motor neural networks via optogenetic stimulation during neurogenesis and synaptogenesis

(2020) Gelson J. Pagan-Diaz et al.   Scientific Reports

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

Ultrafast optical clearing method for three-dimensional imaging with cellular resolution

(2019) Xinpei Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo

(2019) Hyogeun Shin et al.   Nature Communications

Layer-By-Layer: The Case for 3D Bioprinting Neurons to Create Patient-Specific Epilepsy Models

(2019) Natasha Antill-O’Brien et al.   Materials

Formation of neural networks with structural and functional features consistent with small-world network topology on surface-grafted polymer particles

(2019) Vibeke Devold Valderhaug et al.   Royal Society Open Science

Action potential propagation recorded from single axonal arbors using multielectrode arrays

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PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

(2018) Claire C. Homan et al.   NEUROBIOLOGY OF DISEASE

Simultaneous two-photon imaging and two-photon optogenetics of cortical circuits in three dimensions

(2018) Weijian Yang et al.   eLife

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

(2018) Yoonhee Jin et al.   Nature Biomedical Engineering

Optogenetic Peripheral Nerve Immunogenicity

(2018) Benjamin E. Maimon et al.   Scientific Reports

Optogenetic control of iPS cell‐derived neurons in 2D and 3D culture systems using channelrhodopsin‐2 expressed by the SYN1 and CaMKII promoters

(2018) Si‐Yuen Lee et al.   Journal of Tissue Engineering and Regenerative Medicine

Three-dimensional neural cultures produce networks that mimic native brain activity

(2017) Justin L. Bourke et al.   Journal of Tissue Engineering and Regenerative Medicine

Fully integrated silicon probes for high-density recording of neural activity

(2017) James J. Jun et al.   NATURE

Preparation and implementation of optofluidic neural probes for in vivo wireless pharmacology and optogenetics

(2017) Jordan G McCall et al.   Nature Protocols

Modeling Physiological Events in 2D vs. 3D Cell Culture

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Miniaturized, Battery-Free Optofluidic Systems with Potential for Wireless Pharmacology and Optogenetics

(2017) Kyung Nim Noh et al.   Small

Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network

(2017) So Hyun Kim et al.   Nature Communications

Electrophysiological Properties and Viability of Neonatal Rat Ventricular Myocyte Cultures with Inducible ChR2 Expression

(2017) Qince Li et al.   Scientific Reports

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Characterization of nerve-cuff electrode interface for biocompatible and chronic stimulating application

(2016) Yi Jae Lee et al.   SENSORS AND ACTUATORS B-CHEMICAL

Natural lecithin promotes neural network complexity and activity

(2016) Shahrzad Latifi et al.   Scientific Reports

Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture

(2016) A. Odawara et al.   Scientific Reports

On the photovoltaic effect in local field potential recordings

(2016) Sanja Mikulovic et al.   Neurophotonics

Human neural stem cell-derived cultures in three-dimensional substrates form spontaneously functional neuronal networks

(2015) Imogen Smith et al.   Journal of Tissue Engineering and Regenerative Medicine

A multichannel neural probe with embedded microfluidic channels for simultaneous in vivo neural recording and drug delivery

(2015) Hyunjoo J. Lee et al.   LAB ON A CHIP

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

(2015) Jan Müller et al.   LAB ON A CHIP

Multifunctional fibers for simultaneous optical, electrical and chemical interrogation of neural circuits in vivo

(2015) Andres Canales et al.   NATURE BIOTECHNOLOGY

Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals

(2015) Fan Wu et al.   NEURON

Multipotent Caudal Neural Progenitors Derived from Human Pluripotent Stem Cells That Give Rise to Lineages of the Central and Peripheral Nervous System

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Functional connectivity in in vitro neuronal assemblies

(2015) Daniele Poli et al.   Frontiers in Neural Circuits

In Vitro Models for Neurogenesis

(2015) Hassan Azari et al.   Cold Spring Harbor Perspectives in Biology

Phasic Dopaminergic Activity Exerts Fast Control of Cholinergic Interneuron Firing via Sequential NMDA, D2, and D1 Receptor Activation

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Bioengineered functional brain-like cortical tissue

(2014) M. D. Tang-Schomer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

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Network dynamics of 3D engineered neuronal cultures: a new experimental model for in-vitro electrophysiology

(2014) Monica Frega et al.   Scientific Reports

Dynamics of Microvalve Operations in Integrated Microfluidics

(2014) Alan Lau et al.   Micromachines

Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons

(2013) Jiao Jiao et al.   HUMAN MOLECULAR GENETICS

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

(2013) Douglas J. Bakkum et al.   Nature Communications

A three-dimensional neuronal culture technique that controls the direction of neurite elongation and the position of soma to mimic the layered structure of the brain

(2013) Aoi Odawara et al.   RSC Advances

A human Dravet syndrome model from patient induced pluripotent stem cells

(2013) Norimichi Higurashi et al.   Molecular Brain

Monitoring spike train synchrony

(2012) Thomas Kreuz et al.   JOURNAL OF NEUROPHYSIOLOGY

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

(2012) Bozhi Tian et al.   NATURE MATERIALS

Minimum neuron density for synchronized bursts in a rat cortical culture on multi-electrode arrays

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Development of a Three Dimensional Neural Sensing Device by a Stacking Method

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Mesh-based Monte Carlo method using fast ray-tracing in Plücker coordinates

(2010) Qianqian Fang   Biomedical Optics Express

Monte Carlo Simulation of Photon Migration in 3D Turbid Media Accelerated by Graphics Processing Units

(2009) Qianqian Fang et al.   OPTICS EXPRESS

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Detection of bursts in neuronal spike trains by the mean inter-spike interval method

(2008) Lin Chen et al.   Progress in Natural Science-Materials International