Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy

Mitochondrial Functionality in Male Fertility: From Spermatogenesis to Fertilization

(2021) Yoo-Jin Park et al.   Antioxidants

Mitophagy in tumorigenesis and metastasis

(2021) Logan P. Poole et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Apelin-36 Protects HT22 Cells Against Oxygen-Glucose Deprivation/Reperfusion-Induced Oxidative Stress and Mitochondrial Dysfunction by Promoting SIRT1-Mediated PINK1/Parkin-Dependent Mitophagy

(2021) Ziqi Shao et al.   NEUROTOXICITY RESEARCH

Reactive oxygen species (ROS) and their impact in neurodegenerative diseases: literature landscape analysis

(2020) Andy Wai Kan Yeung et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial ROS and Mitophagy: A Complex and Nuanced Relationship

(2020) James H. Schofield et al.   ANTIOXIDANTS & REDOX SIGNALING

Transforming growth factor β1 accelerates and enhances in vitro red blood cell formation from hematopoietic stem cells by stimulating mitophagy

(2020) Rutuja Kuhikar et al.   Stem Cell Research & Therapy

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

(2020) Xiaoli Wu et al.   Autophagy

Mitochondrial ROS in myocardial ischemia reperfusion and remodeling

(2020) Heiko Bugger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

miR-330 regulates Drp-1 mediated mitophagy by targeting PGAM5 in a rat model of permanent focal cerebral ischemia

(2020) Wei Zuo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased PINK1/Parkin-mediated mitophagy explains the improved brain protective effects of slow rewarming following hypothermia after cardiac arrest in rats

(2020) Yue Hu et al.   EXPERIMENTAL NEUROLOGY

Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation

(2020) Yifan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction

(2020) Chen Li et al.   Frontiers in Cell and Developmental Biology

Selective autophagy as a therapeutic target for neurological diseases

(2020) Weilin Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Management of Acute Ischemic Stroke

(2020) Franziska Herpich et al.   CRITICAL CARE MEDICINE

Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives

(2020) Diji Kuriakose et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy

(2020) Ming Ye et al.   Molecular Medicine Reports

The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons

(2020) Md. Nazmul Haque et al.   PHYTOMEDICINE

FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury

(2020) Ying Cai et al.   Redox Biology

Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

(2019) Chen-chen Cai et al.   Oxidative Medicine and Cellular Longevity

Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy

(2019) Victoria Riccio et al.   JOURNAL OF CELL BIOLOGY

Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future

(2019) Keita Shibata et al.   CURRENT PHARMACEUTICAL DESIGN

Health benefits of resveratrol administration

(2019) Sabina Galiniak et al.   ACTA BIOCHIMICA POLONICA

Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI

(2019) Yuhua Chen et al.   BRAIN RESEARCH

Stroke in China: advances and challenges in epidemiology, prevention, and management

(2019) Simiao Wu et al.   LANCET NEUROLOGY

Mitophagy Reduces Oxidative Stress Via Keap1 (Kelch-Like Epichlorohydrin-Associated Protein 1)/Nrf2 (Nuclear Factor-E2-Related Factor 2)/PHB2 (Prohibitin 2) Pathway After Subarachnoid Hemorrhage in Rats

(2019) Tongyu Zhang et al.   STROKE

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

(2019) Maria Zachari et al.   DEVELOPMENTAL CELL

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

(2019) He et al.   Cells

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles

(2019) Sylwia Dabrowska et al.   Journal of Neuroinflammation

Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion

(2019) Huanyuan Wang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Structure effect of water-soluble iron porphyrins on catalyzing protein tyrosine nitration in the presence of nitrite and hydrogen peroxide

(2019) Jiayu Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Resveratrol in experimental Alzheimer’s disease models: A systematic review of preclinical studies

(2019) Jia-Yue Chen et al.   PHARMACOLOGICAL RESEARCH

Viral Strategies for Triggering and Manipulating Mitophagy

(2018) Linliang Zhang et al.   Autophagy

Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights

(2018) Jessica A. Williams et al.   BIOLOGICAL CHEMISTRY

Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway

(2018) Xinwei Wu et al.   BRAIN RESEARCH

Necroptosis signaling pathways in stroke: from mechanisms to therapies

(2018) Huang Jun-Long et al.   Current Neuropharmacology

Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation

(2018) Qiong Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tele-Rehabilitation after Stroke: An Updated Systematic Review of the Literature

(2018) Fred S. Sarfo et al.   Journal of Stroke & Cerebrovascular Diseases

Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation

(2018) Jinghan Feng et al.   MOLECULAR NEUROBIOLOGY

Inhibition of Peroxynitrite-Induced Mitophagy Activation Attenuates Cerebral Ischemia-Reperfusion Injury

(2018) Jinghan Feng et al.   MOLECULAR NEUROBIOLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

(2018) Charleen T. Chu   NEUROBIOLOGY OF DISEASE

Stigmasterol upregulates immediate early genes and promotes neuronal cytoarchitecture in primary hippocampal neurons as revealed by transcriptome analysis

(2018) Md. Nazmul Haque et al.   PHYTOMEDICINE

Global Burden of Stroke

(2018) Mira Katan et al.   SEMINARS IN NEUROLOGY

Tele-Rehabilitation after Stroke: An Updated Systematic Review of the Literature

(2018) Fred S. Sarfo et al.   Journal of Stroke & Cerebrovascular Diseases

The structure of the deubiquitinase USP15 reveals a misaligned catalytic triad and an open ubiquitin-binding channel

(2018) Stephanie J Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin Upregulates Nuclear Factor Erythroid-2 Related Factor 2 (Nrf2) and Mediates Mitophagy to Protect Against Early Brain Injury After Subarachnoid Hemorrhage

(2018) Bin Sun et al.   MEDICAL SCIENCE MONITOR

Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke

(2018) Nandan K. Mondal et al.   NEUROCHEMISTRY INTERNATIONAL

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

(2018) Qiang Li et al.   Frontiers in Neuroscience

Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life

(2017) Caroline A. McHutchison et al.   EPIDEMIOLOGY

Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study

(2017) Viktoria Moschetti et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

(2017) Shanshan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New methods for monitoring mitochondrial biogenesis and mitophagy in vitro and in vivo

(2017) Jessica A Williams et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

(2017) Claire Thornton et al.   FEBS LETTERS

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

(2017) Nikolaos D. Georgakopoulos et al.   Scientific Reports

Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke

(2017) Jian Qiu et al.   Frontiers in Neurology

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury

(2016) Qiong Wu et al.   BRAIN RESEARCH

Phospho-ubiquitin: upending the PINK–Parkin–ubiquitin cascade

(2016) Noriyuki Matsuda   JOURNAL OF BIOCHEMISTRY

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

(2016) Thomas G. McWilliams et al.   JOURNAL OF CELL BIOLOGY

Sex-dependent mitophagy and neuronal death following rat neonatal hypoxia–ischemia

(2016) T.G. Demarest et al.   NEUROSCIENCE

Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy

(2016) Shoushui Yu et al.   NEUROSCIENCE LETTERS

Structure of phosphorylated UBL domain and insights into PINK1-orchestrated parkin activation

(2016) Jacob D. Aguirre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical roles of mitophagy in cerebral ischemia

(2016) Yan-Cheng Tang et al.   Protein & Cell

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

The effect of mitochondrial calcium uniporter on mitochondrial fission in hippocampus cells ischemia/reperfusion injury

(2015) Lantao Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

(2015) Hélène C. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

Unknown

(2015) Yao Di et al.   MOLECULAR MEDICINE

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

(2015) J. Claude Hemphill et al.   STROKE

To be or not to be? Examples of incorrect identification of autophagic compartments in conventional transmission electron microscopy of mammalian cells

(2014) Eeva-Liisa Eskelinen   Autophagy

Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats

(2014) Hai-Yang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Voltage-dependent anion channels (VDACs) promote mitophagy to protect neuron from death in an early brain injury following a subarachnoid hemorrhage in rats

(2014) Jian Li et al.   BRAIN RESEARCH

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart

(2014) Roberta A. Gottlieb et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Application and interpretation of current autophagy inhibitors and activators

(2013) Ya-ping Yang et al.   ACTA PHARMACOLOGICA SINICA

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

(2013) Andrew W Ferree et al.   Autophagy

MitoTimer

(2013) Genaro Hernandez et al.   Autophagy

Role of histidine/histamine in carnosine-induced neuroprotection during ischemic brain damage

(2013) Ok-Nam Bae et al.   BRAIN RESEARCH

A Novel Neuroprotective Strategy for Ischemic Stroke: Transient Mild Acidosis Treatment by CO2 Inhalation at Reperfusion

(2013) Yan-Ying Fan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin

(2013) X. Sun et al.   JOURNAL OF NEUROSCIENCE

Common Variants Within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage

(2013) Christopher D. Anderson et al.   STROKE

Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival MitophagyversusApoptosis

(2012) Yanyan Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy

(2012) Yu Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion

(2012) Santosh Kumari et al.   Translational Stroke Research

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy

(2010) Jennifer J. Kurinczuk et al.   EARLY HUMAN DEVELOPMENT

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters

(2009) Jeong-Sun Ju et al.   Autophagy

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions

(2009) Clelia Miracco et al.   HUMAN PATHOLOGY

Dynamics and diversity in autophagy mechanisms: lessons from yeast

(2009) Hitoshi Nakatogawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions

(2009) G Chinnadurai et al.   ONCOGENE

Pretreatment With Electroacupuncture Induces Rapid Tolerance to Focal Cerebral Ischemia Through Regulation of Endocannabinoid System

(2009) Qiang Wang et al.   STROKE

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE