Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism

(2018) Shi-gang Qiao et al.   ACTA PHARMACOLOGICA SINICA

CoCl2 induces apoptosis via ROS-dependent pathway and Drp1-mediated mitochondria fission in the periodontal ligament stem cells

(2018) Yuting He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Glycine confers neuroprotection through PTEN/AKT signal pathway in experimental intracerebral hemorrhage

(2018) Dan Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

CpG-ODN exerts a neuroprotective effect via the TLR9/pAMPK signaling pathway by activation of autophagy in a neonatal HIE rat model

(2018) Lan Ye et al.   EXPERIMENTAL NEUROLOGY

Haemin attenuates intermittent hypoxia-induced cardiac injury via inhibiting mitochondrial fission

(2018) Qian Han et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TAK1 mediates excessive autophagy via p38 and ERK in cisplatin-induced acute kidney injury

(2018) Jun Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oxymatrine attenuates brain hypoxic-ischemic injury from apoptosis and oxidative stress: role of p-Akt/GSK3β/HO-1/Nrf-2 signaling pathway

(2018) Xu-Hua Ge et al.   METABOLIC BRAIN DISEASE

Quantifying autophagy using novel LC3B and p62 TR-FRET assays

(2018) Alberto Bresciani et al.   PLoS One

Mesenchymal Stem Cells Protect Against Hypoxia-Ischemia Brain Damage by Enhancing Autophagy Through Brain Derived Neurotrophic Factor/Mammalin Target of Rapamycin Signaling Pathway

(2018) Zhen Zheng et al.   STEM CELLS

PINK1/Parkin-mediated mitophagy was activated against 1,4-Benzoquinone-induced apoptosis in HL-60 cells

(2018) Chunxiao Zhang et al.   TOXICOLOGY IN VITRO

Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study

(2017) Viktoria Moschetti et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Reactive astrocyte COX2-PGE2 production inhibits oligodendrocyte maturation in neonatal white matter injury

(2017) Lawrence R. Shiow et al.   GLIA

Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture

(2017) Shengxiang Liang et al.   Journal of Stroke & Cerebrovascular Diseases

Amelioration by glycine of brain damage in neonatal rat brain following hypoxia-ischemia

(2017) Hiroko Mori et al.   PEDIATRICS INTERNATIONAL

Early neonatal death: A challenge worldwide

(2017) Liisa Lehtonen et al.   Seminars in Fetal & Neonatal Medicine

Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture

(2017) Shengxiang Liang et al.   Journal of Stroke & Cerebrovascular Diseases

Therapeutic effects of L -Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H 2 S system: Role of oxidative stress and endoplasmic reticulum stress

(2017) Song Liu et al.   Redox Biology

Evolution of Energy Related Metabolites in Plasma from Newborns with Hypoxic-Ischemic Encephalopathy during Hypothermia Treatment

(2017) Ángel Sánchez-Illana et al.   Scientific Reports

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

(2016) Yair Romero et al.   AGING CELL

The yin and yang of autophagy in acute kidney injury

(2016) Anette Melk et al.   Autophagy

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling

(2016) Hyowon Choi et al.   Autophagy

Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease

(2016) Alice Nardin et al.   Current Neuropharmacology

Icariside II, a novel phosphodiesterase 5 inhibitor, protects against H2O2-induced PC12 cells death by inhibiting mitochondria-mediated autophagy

(2016) Jianmei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury

(2016) Wenting Zhang et al.   NEUROBIOLOGY OF DISEASE

Glycine inhibits ethanol-induced oxidative stress, neuroinflammation and apoptotic neurodegeneration in postnatal rat brain

(2016) Faiz Ul Amin et al.   NEUROCHEMISTRY INTERNATIONAL

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

(2016) Danielle N. Feather-Schussler et al.   Jove-Journal of Visualized Experiments

Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro

(2015) Alicia K. Au et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy

(2015) Clàudia Cerveró et al.   Neurotherapeutics

AMPK: energy sensor and survival mechanism in the ischemic heart

(2015) Dake Qi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Hypoxic-Ischemic Encephalopathy

(2015) Martha Douglas-Escobar et al.   JAMA Pediatrics

Autophagy in neonatal hypoxia ischemic brain is associated with oxidative stress

(2015) Qing Lu et al.   Redox Biology

Autophagy and mammalian development

(2015) Xiaoting Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SUMO1 promotes Aβ production via the modulation of autophagy

(2014) Sun-Jung Cho et al.   Autophagy

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink–parkin pathway

(2014) Giuseppina Amadoro et al.   Frontiers in Aging Neuroscience

The protective role of AMP-activated protein kinase in alpha-synuclein neurotoxicity in vitro

(2013) Marija Dulovic et al.   NEUROBIOLOGY OF DISEASE

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

(2012) José Manuel Rodríguez-Vargas et al.   CELL RESEARCH

Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge

(2011) Frank Petrat et al.   BRITISH JOURNAL OF PHARMACOLOGY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Autophagy Signaling Through Reactive Oxygen Species

(2010) Ju Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Selective Autophagy in Cancer Development and Therapy

(2010) Ivan Dikic et al.   CANCER RESEARCH

Glycine-induced cytoprotection is mediated by ERK1/2 and AKT in renal cells with ATP depletion

(2010) Linglin Jiang et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A Pharmacological Activator of AMP-Activated Protein Kinase Protects Hypoxic Neurons in a Concentration-Dependent Manner

(2010) Xiaolu Zhang et al.   NEUROCHEMICAL RESEARCH

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

(2009) Narasimman Gurusamy et al.   CARDIOVASCULAR RESEARCH

Glycine and glycine receptor signalling in non-neuronal cells

(2009) Jimmy Van den Eynden   Frontiers in Molecular Neuroscience

Brain damage related to hemorrhagic transformation following cerebral ischemia and the role of KATP channels

(2008) Yi Yang et al.   BRAIN RESEARCH

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE