Article
Biochemistry & Molecular Biology
Giang Thanh Nguyen-Dien, Keri-Lyn Kozul, Yi Cui, Brendan Townsend, Prajakta Gosavi Kulkarni, Soo Siang Ooi, Antonio Marzio, Nissa Carrodus, Steven Zuryn, Michele Pagano, Robert G. Parton, Michael Lazarou, S. Sean Millard, Robert W. Taylor, Brett M. Collins, Mathew J. K. Jones, Julia K. Pagan
Summary: To maintain mitochondrial quality and quantity, cells use mitophagy to selectively remove damaged or excessive mitochondria. SCFFBXL4, a protein ubiquitin ligase complex that localises to the mitochondrial outer membrane, plays a role in constitutive ubiquitylation and degradation of mitophagy receptors NIX and BNIP3, thus suppressing basal levels of mitophagy.
Article
Biochemistry & Molecular Biology
Yanning Huang, Qiaolin Wen, Jinfeng Huang, Man Luo, Yousheng Xiao, Ruikang Mo, Jin Wang
Summary: The study demonstrated that MnCl2 induces mitophagy and neurotoxicity in dopaminergic SH-SY5Y cells through BNIP3-mediated ROS generation. This suggests that BNIP3 plays a role in manganese-induced neurotoxicity by acting as a mitophagy receptor protein.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Immunology
Liyun Wu, Qiaozhen Chen, Bo Dong, Hancheng Geng, Yu Wang, Dong Han, Xiaoming Zhu, Haokun Liu, Zhimin Zhang, Yunxia Yang, Shouqi Xie, Junyan Jin
Summary: This study aimed to determine whether and how resveratrol (RES) can alleviate liver injury in lipopolysaccharide (LPS)-induced gibel carp. The results suggested that RES attenuated oxidative stress and inflammation by activating the Nrf2/Keap1 pathway and inhibiting the NF-kappa B pathway. Furthermore, RES cleared damaged mitochondria and enhanced mitochondrial biogenesis to mitigate reactive oxygen species (ROS) accumulation. Overall, RES alleviated LPS-induced oxidative stress and inflammation in gibel carp through mitochondria-related mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Anna Li, Man Zhao, Zexin Yang, Zhenya Fang, Weiyi Qi, Changqing Zhang, Meijuan Zhou, Junjun Guo, Shuxian Li, Xietong Wang, Meihua Zhang
Summary: The protective effect of 6-Gingerol against placental injury in preeclampsia was demonstrated through reducing oxidative stress and inhibiting excessive mitophagy caused by mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Huixian Zheng, Chaoyi Hu, Yunyun Quan, Xiaoxia Ye, Xiangchao Shi, Zijian Guo, Xiaoyong Wang
Summary: A phenanthroline copper(ii) complex CPT8 modified with an alkyl chain-linked triphenylphosphonium group showed potent antiproliferative activity against TNBC cells and induced mitophagy through activation of PINK1/Parkin and BNIP3 pathways. It also exhibited anti-angiogenic effects by decreasing the tube formation ability of HUVEC and downregulating the expression of Nrf2, VEGF, and CD34. Furthermore, CPT8 inhibited vasculogenic mimicry formation and suppressed the metastatic potential of MDA-MB-231 cells, making it a promising metal drug candidate for TNBC treatment.
DALTON TRANSACTIONS
(2023)
Article
Environmental Sciences
Xin-Le Lai, Wen-Jie Xiong, Li-Shu Li, Meng-Fan Lan, Jin-Xin Zhang, Yu-Ting Zhou, Dong Niu, Xing Duan
Summary: Zinc, an essential trace mineral, plays a critical role in various cellular processes. Zinc deficiency in patients with polycystic ovary syndrome (PCOS) has been found to affect the reproductive system, particularly oocyte quality. This study established an in vitro model to investigate the regulatory function of zinc in porcine oocyte maturation. The results showed that zinc deficiency disrupted meiotic progress and cytoskeleton structure, impaired mitochondrial function, perturbed cytosolic Ca2+ homeostasis, and induced mitophagy in porcine oocytes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: Mitochondria play vital roles in plant metabolism and stress responses. Quality control systems, including mitophagy, are important for maintaining a healthy mitochondrial pool. The 'Friendly Mitochondria' protein (FMT) has been identified as a crucial player in mitophagy during dark-induced senescence in Arabidopsis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Editorial Material
Cell Biology
Kun Gao, Yingji Chen, Ren Mo, Chenji Wang
Summary: Mitophagy is important for cell survival, but excessive or uncontrolled mitophagy can lead to cell death. FBXL4 mutations are linked to mitochondrial DNA depletion syndrome, and the CRL1-FBXL4 complex regulates basal mitophagy.
Article
Biochemistry & Molecular Biology
Jingzeng Cai, Jiaqiang Huang, Jie Yang, Xiaoming Chen, Haoran Zhang, Yue Zhu, Qi Liu, Ziwei Zhang
Summary: This study reveals the role of selenoprotein M (SELENOM) in maintaining mitophagy in high-fat diet-induced non-alcoholic fatty liver disease (NAFLD). SELENOM downregulation aggravates hepatic steatosis, inflammation, and fibrosis, while reducing mitophagy and increasing mitochondrial apoptosis. SELENOM overexpression activates Parkin-mediated mitophagy, reducing mitochondrial apoptosis and removing damaged mitochondria.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Renal aging is a degenerative process associated with harmful accumulation. Mitochondria, the energy factories of the cell, play important roles in renal aging through abnormal mitochondrial homeostasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar
Summary: This study found that supplementing GlyNAC can increase the lifespan of mice and improve multiple age-associated defects. GlyNAC could be a new nutritional supplement to improve lifespan and healthspan.
Article
Medicine, Research & Experimental
Zafer Yonden, Farzaneh Bonyadi, Yavar Yousefi, Amin Daemi, Seyyedeh Touran Hosseini, Sana Moshari
Summary: This study reveals that chronic and high-dose nano-micelle curcumin (NMC) can suppress the redox capacity and stimulate mitophagy signaling in the testicles.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Vedavathi Madhu, Miriam Hernandez-Meadows, Paige K. Boneski, Yunping Qiu, Anyonya R. Guntur, Irwin J. Kurland, Ruteja A. Barve, Makarand V. Risbud
Summary: The contribution of mitochondria to the metabolic function of hypoxic NP cells has been overlooked. We have shown that BNIP3 mediates hypoxia-induced mitophagy, and now we find that BNIP3 also plays a role in governing mitochondrial function and metabolism in hypoxic NP cells.
Article
Biochemistry & Molecular Biology
Hannah Elcocks, Ailbhe J. Brazel, Katy R. McCarron, Manuel Kaulich, Koraljka Husnjak, Heather Mortiboys, Michael J. Clague, Sylvie Urbe
Summary: Selective autophagy of mitochondria, mitophagy, is critical to maintain mitochondrial quality control. Through a CRISPR/Cas9 approach, we identified two proteins, VHL and FBXL4, which act as negative regulators of basal mitophagy by controlling the levels of mitophagy adaptors BNIP3 and BNIP3L/NIX via different mechanisms. Depletion of NIX, but not BNIP3, restores mitophagy levels, providing insights into the pathogenesis of early-onset mitochondrial encephalomyopathy. We also found that a compound called MLN4924 can induce mitophagy, making it a potential therapeutic agent for mitochondrial dysfunction-related conditions.
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)