BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

Nix/BNIP3L-dependent mitophagy accounts for airway epithelial cell injury induced by cigarette smoke

(2019) Ming Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation

(2019) Mark A. Lampert et al.   Autophagy

Mild Acidosis Protects Neurons during Oxygen-Glucose Deprivation by Reducing Loss of Mitochondrial Respiration

(2019) Ming-Yue Zhu et al.   ACS Chemical Neuroscience

Potential Roles of NIX/BNIP3L Pathway in Rat Traumatic Brain Injury

(2019) Jialing Ma et al.   CELL TRANSPLANTATION

Somatic autophagy of axonal mitochondria in ischemic neurons

(2019) Yanrong Zheng et al.   JOURNAL OF CELL BIOLOGY

Multimorbidity in Stroke

(2019) Katie I. Gallacher et al.   STROKE

Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13

(2019) Dongxiao Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs

(2018) Rowena Rodrigo et al.   Autophagy

Hyperglycemia abolished Drp-1-mediated mitophagy at the early stage of cerebral ischemia

(2018) Wei Zuo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib

(2018) Betul Karademir et al.   Scientific Reports

Opening a New Time Window for Treatment of Stroke by Targeting HDAC2

(2017) Yu-Hui Lin et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury

(2017) Anthony R. Anzell et al.   MOLECULAR NEUROBIOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

(2016) Mariana Lazarini et al.   HAEMATOLOGICA

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

(2016) Thomas G. McWilliams et al.   JOURNAL OF CELL BIOLOGY

Reversible Disruption of Neuronal Mitochondria by Ischemic and Traumatic Injury Revealed by Quantitative Two-Photon Imaging in the Neocortex of Anesthetized Mice

(2016) Mikhail Kislin et al.   JOURNAL OF NEUROSCIENCE

Autophagy in acute brain injury

(2016) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion

(2016) Eun Il Jeong et al.   Cell Death & Disease

The critical roles of mitophagy in cerebral ischemia

(2016) Yan-Cheng Tang et al.   Protein & Cell

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

(2016) Mariana Lazarini et al.   HAEMATOLOGICA

BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32

(2015) Kinya Otsu et al.   Autophagy

BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Regulation of mitophagy in ischemic brain injury

(2015) Yang Yuan et al.   Neuroscience Bulletin

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

Role of Glucose Metabolism and ATP in Maintaining PINK1 Levels during Parkin-mediated Mitochondrial Damage Responses

(2014) Schuyler Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

U.S. Food and Drug Administration Approval: Carfilzomib for the Treatment of Multiple Myeloma

(2013) T. M. Herndon et al.   CLINICAL CANCER RESEARCH

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Excitotoxic stimulation downregulates the ubiquitin–proteasome system through activation of NMDA receptors in cultured hippocampal neurons

(2012) Margarida V. Caldeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma

(2012) R. Vij et al.   BLOOD

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

BNIP3 and NIX Mediate Mieap-Induced Accumulation of Lysosomal Proteins within Mitochondria

(2012) Yasuyuki Nakamura et al.   PLoS One

Combination Treatment With VELCADE and Low-Dose Tissue Plasminogen Activator Provides Potent Neuroprotection in Aged Rats After Embolic Focal Ischemia

(2010) Li Zhang et al.   STROKE

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

(2008) Chikanori Kuramori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitophagy in Yeast Occurs through a Selective Mechanism

(2008) Tomotake Kanki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapidly Increased Neuronal Mitochondrial Biogenesis After Hypoxic-Ischemic Brain Injury

(2008) Wei Yin et al.   STROKE