Noradrenergic circuits and signaling in substance use disorders

Increases in Naloxone Administrations by Emergency Medical Services Providers During the COVID-19 Pandemic: Retrospective Time Series Study

(2021) Dalia Khoury et al.   JMIR Public Health and Surveillance

α2A-adrenergic heteroreceptors are required for stress-induced reinstatement of cocaine conditioned place preference

(2020) Rafael E. Perez et al.   NEUROPSYCHOPHARMACOLOGY

Doxazosin treatment in cocaine use disorder: pharmacogenetic response based on an alpha-1 adrenoreceptor subtype D genetic variant

(2020) Daryl I. Shorter et al.   AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE

Effects of Prazosin on Provoked Alcohol Craving and Autonomic and Neuroendocrine Response to Stress in Alcohol Use Disorder

(2020) Verica Milivojevic et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice

(2020) Shintaro Wada et al.   NEUROPHARMACOLOGY

Abstinence-dependent dissociable central amygdala microcircuits control drug craving

(2020) Marco Venniro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous Ethanol Administration and Operant Self‐Administration Alter Extracellular Norepinephrine Concentration in the Mesocorticolimbic Systems of Male Long Evans Rats

(2020) Saul Jaime et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms

(2020) Rajita Sinha et al.   AMERICAN JOURNAL OF PSYCHIATRY

Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

(2020) Liang Ye et al.   Nature Communications

The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming

(2019) Julie E. Finnell et al.   BRAIN BEHAVIOR AND IMMUNITY

Alpha1-adrenergic receptor blockade in the ventral tegmental area modulates conditional stimulus-induced cocaine seeking

(2019) Wojciech B. Solecki et al.   NEUROPHARMACOLOGY

Nicotine, cocaine, amphetamine, morphine, and ethanol increase norepinephrine output in the bed nucleus of stria terminalis of freely moving rats

(2019) Dragana Jadzic et al.   ADDICTION BIOLOGY

Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin

(2018) Xuefeng Zhang et al.   ADDICTION BIOLOGY

Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long-term ethanol intake

(2018) Omkar L. Patkar et al.   ADDICTION BIOLOGY

Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry

(2018) Fumiya Shinohara et al.   ADDICTION BIOLOGY

Noradrenergic β-receptor antagonism in the basolateral amygdala impairs reconsolidation, but not extinction, of alcohol self-administration

(2018) Rose Chesworth et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans

(2018) Murray A. Raskind et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning

(2018) Jorge Tovar-Díaz et al.   Cell Reports

Stress-Induced Alterations of Norepinephrine Release in the Bed Nucleus of the Stria Terminalis of Mice

(2018) Karl T. Schmidt et al.   ACS Chemical Neuroscience

Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder

(2018) Tracy L. Simpson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Sex differences in morphine-induced trafficking of mu-opioid and corticotropin-releasing factor receptors in locus coeruleus neurons

(2018) Nicole M. Enman et al.   BRAIN RESEARCH

Noradrenergic and corticosteroid receptors regulate somatic and motivational symptoms of morphine withdrawal

(2018) Wojciech B. Solecki et al.   BEHAVIOURAL BRAIN RESEARCH

Modular organization of the brainstem noradrenaline system coordinates opposing learning states

(2017) Akira Uematsu et al.   NATURE NEUROSCIENCE

Norepinephrine regulates cocaine-primed reinstatement via α1-adrenergic receptors in the medial prefrontal cortex

(2017) Karl T. Schmidt et al.   NEUROPHARMACOLOGY

The bed nucleus of the stria terminalis in drug-associated behavior and affect: A circuit-based perspective

(2017) Oliver Vranjkovic et al.   NEUROPHARMACOLOGY

Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability

(2017) Sudarat Nimitvilai et al.   NEUROPSYCHOPHARMACOLOGY

Voluntary Binge-like Ethanol Consumption Site-specifically Increases c-Fos Immunoexpression in Male C57BL6/J Mice

(2017) Nathan W. Burnham et al.   NEUROSCIENCE

Multiple Naloxone Administrations Among Emergency Medical Service Providers is Increasing

(2017) Mark Faul et al.   Prehospital Emergency Care

The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice

(2016) Omkar L. Patkar et al.   ADDICTION BIOLOGY

Disentangling the Role of Astrocytes in Alcohol Use Disorder

(2016) Louise Adermark et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Noradrenergic dysregulation in the pathophysiology of PTSD

(2016) Rebecca C. Hendrickson et al.   EXPERIMENTAL NEUROLOGY

Contributions of the Central Extended Amygdala to Fear and Anxiety

(2016) A. J. Shackman et al.   JOURNAL OF NEUROSCIENCE

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

(2016) M A Lebow et al.   MOLECULAR PSYCHIATRY

Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal

(2016) Megan E Fox et al.   NEUROPSYCHOPHARMACOLOGY

The blockade of GABA A receptors attenuates the inhibitory effect of orexin type 1 receptors antagonist on morphine withdrawal syndrome in rats

(2016) Mahnaz Davoudi et al.   NEUROSCIENCE LETTERS

Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model

(2016) Shelly B. Flagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noradrenergic inputs from locus coeruleus to posterior ventral tegmental area are essential to support ethanol reinforcement

(2015) Gajanan P. Shelkar et al.   ADDICTION BIOLOGY

A Pilot Trial of Prazosin, an Alpha-1 Adrenergic Antagonist, for Comorbid Alcohol Dependence and Posttraumatic Stress Disorder

(2015) Tracy L. Simpson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The Central Amygdala as an Integrative Hub for Anxiety and Alcohol Use Disorders

(2015) Nicholas W. Gilpin et al.   BIOLOGICAL PSYCHIATRY

The dark side of emotion: The addiction perspective

(2015) George F. Koob   EUROPEAN JOURNAL OF PHARMACOLOGY

CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety

(2015) Jordan G. McCall et al.   NEURON

The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice

(2015) Melanie M. Pina et al.   NEUROPHARMACOLOGY

Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference

(2015) M. Carmen Lasheras et al.   NEUROPHARMACOLOGY

Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress

(2015) John R Mantsch et al.   NEUROPSYCHOPHARMACOLOGY

The α2-adrenergic receptor agonist, clonidine, reduces alcohol drinking in alcohol-preferring (P) rats

(2014) Dennis D. Rasmussen et al.   ALCOHOL

Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area

(2014) O. Vranjkovic et al.   JOURNAL OF NEUROSCIENCE

Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats

(2014) J. Su et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Sex Differences in Guanfacine Effects on Drug Craving and Stress Arousal in Cocaine-Dependent Individuals

(2014) Helen C Fox et al.   NEUROPSYCHOPHARMACOLOGY

The Central Amygdala Nucleus is Critical for Incubation of Methamphetamine Craving

(2014) Xuan Li et al.   NEUROPSYCHOPHARMACOLOGY

Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice

(2014) Jayme R. McReynolds et al.   PSYCHOPHARMACOLOGY

Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use

(2014) Mary J. Skelly et al.   Brain and Behavior

A Trial of Prazosin for Combat Trauma PTSD With Nightmares in Active-Duty Soldiers Returned From Iraq and Afghanistan

(2013) Murray A. Raskind et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mechanisms in the Bed Nucleus of the Stria Terminalis Involved in Control of Autonomic and Neuroendocrine Functions: A Review

(2013) Carlos Crestani et al.   Current Neuropharmacology

The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study

(2013) D. Shorter et al.   DRUG AND ALCOHOL DEPENDENCE

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

Developmental origins of central norepinephrine neuron diversity

(2013) Sabrina D Robertson et al.   NATURE NEUROSCIENCE

Differential role of ventral tegmental area acetylcholine and N-methyl-d-aspartate receptors in cocaine-seeking

(2013) Wojciech Solecki et al.   NEUROPHARMACOLOGY

The Selective Dopamine β-Hydroxylase Inhibitor Nepicastat Attenuates Multiple Aspects of Cocaine-Seeking Behavior

(2013) Jason P Schroeder et al.   NEUROPSYCHOPHARMACOLOGY

Noradrenergic Synaptic Function in the Bed Nucleus of the Stria Terminalis Varies in Animal Models of Anxiety and Addiction

(2013) Zoé A McElligott et al.   NEUROPSYCHOPHARMACOLOGY

Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area and Locus Coeruleus Catecholamine Neurons

(2013) M. S. Mazei-Robison et al.   Cold Spring Harbor Perspectives in Medicine

Regulation of the ventral tegmental area by the bed nucleus of the stria terminalis is required for expression of cocaine preference

(2012) Gregory C. Sartor et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orienting and Reorienting: The Locus Coeruleus Mediates Cognition through Arousal

(2012) Susan J. Sara et al.   NEURON

Prazosin Effects on Stress- and Cue-Induced Craving and Stress Response in Alcohol-Dependent Individuals: Preliminary Findings

(2011) Helen C. Fox et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Amygdalar peptidergic circuits regulating noradrenergic locus coeruleus neurons: Linking limbic and arousal centers

(2011) B.A.S. Reyes et al.   EXPERIMENTAL NEUROLOGY

Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility

(2011) Kevin Snyder et al.   NEUROPSYCHOPHARMACOLOGY

Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functions

(2010) Linda Rinaman   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala

(2010) Zenya J. Brown et al.   BEHAVIOURAL BRAIN RESEARCH

Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons

(2010) J.-L. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

(2010) Nicholas W. Gilpin et al.   PSYCHOPHARMACOLOGY

Lofexidine, an α2-Receptor Agonist for Opioid Detoxification

(2009) Emily C Gish et al.   ANNALS OF PHARMACOTHERAPY

Chronic Stress, Drug Use, and Vulnerability to Addiction

(2009) Rajita Sinha   Annals of the New York Academy of Sciences

Central sympathetic overactivity: Maladies and mechanisms

(2009) James P. Fisher et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Brain stress systems in the amygdala and addiction

(2009) George F. Koob   BRAIN RESEARCH

α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis

(2009) A.D. Shields et al.   NEUROSCIENCE

Sex Differences in Drug-Related Stress-System Changes

(2009) Helen C. Fox et al.   HARVARD REVIEW OF PSYCHIATRY

α1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol

(2008) Brendan M. Walker et al.   ALCOHOL

Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence

(2008) Rachel J. Smith et al.   Brain Structure & Function

A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal☆

(2008) E YU et al.   DRUG AND ALCOHOL DEPENDENCE

Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice

(2008) Maria Torrecilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Double Dissociation of the Effects of Medial and Orbital Prefrontal Cortical Lesions on Attentional and Affective Shifts in Mice

(2008) G. B. Bissonette et al.   JOURNAL OF NEUROSCIENCE

Yohimbine impairs extinction of cocaine-conditioned place preference in an  2-adrenergic receptor independent process

(2008) A. R. Davis et al.   LEARNING & MEMORY

Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics.

(2008) Catherine Brawn Fortier et al.   NEUROPSYCHOLOGY

The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration

(2008) Thomas N. Greenwell et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Addiction and the Brain Antireward System

(2007) George F. Koob et al.   Annual Review of Psychology