Article
Neurosciences
Angela E. Gonzalez, Emily T. Jorgensen, Jonathan D. Ramos, John H. Harkness, Jake A. Aadland, Travis E. Brown, Barbara A. Sorg
Summary: Parvalbumin (PV) positive cells in the medial prefrontal cortex (mPFC) regulate the activity of pyramidal neurons and are surrounded by a structure called the perineuronal net (PNN). The removal of PNNs with chondroitinase-ABC (Ch-ABC) prevents the consolidation and reconsolidation of cocaine-associated conditioned place preference (CPP) memories. This study explores the effects of CPP memory retrieval during cocaine-primed reinstatement on PV neurons and PNNs, and the impact of PNN removal on PV intensity and function. The findings suggest that PNN removal partially reduces reinstatement and that cocaine-induced reinstatement leads to changes in PV intensity and excitability, potentially affecting the maintenance of cocaine memory during reconsolidation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Wanyu Tu, Tengteng Zhang, Chenchen Li, Wenge Jia, Zhijun Yao, Shanyong Yi, Hongyun Chen, Yuan Liu, Danya Zhou, Chuansheng Wang, Ruiling Zhang, Zhe Shi, Tifei Yuan, Bin Zhao, Lai Wei
Summary: This study investigated the role of alpha 1 adrenoceptor in the ventrolateral orbital cortex of rats with repeated morphine treatment and its underlying molecular mechanisms. The results showed that prazosin enhanced the addictive effects of morphine and affected neurotransmitter NE and peripheral inflammatory factors. These findings suggest that the NE system may be a potential therapeutic target in morphine addiction.
Article
Neurosciences
Shole Jamali, Shahram Zarrabian, Abbas Haghparast
Summary: The study demonstrated that Orx1Rs in the mPFC regulate the reward-related effects of morphine- and food-induced reward behaviors.
Article
Neurosciences
Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen
Summary: The study demonstrates that simvastatin can prevent the reinstatement of cocaine-induced conditioned place preference without affecting its acquisition, likely due to its administration during extinction phase. Lipidomic analysis reveals that the nucleus accumbens is the most affected brain region by simvastatin, with alterations in fatty acids, phospholipids, and triacylglycerol metabolism. Simvastatin reverses most effects on phospholipids induced by cocaine and reshapes lipid metabolic pathways in specific brain regions, ultimately facilitating cocaine extinction and preventing relapse.
NEUROSCIENCE BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Christina R. Merritt, Ashley E. Smith, Kamil Khanipov, George Golovko, Kelly T. Dineley, Noelle C. Anastasio, Kathryn A. Cunningham
Summary: The lack of FDA-approved medications for the treatment of cocaine use disorder (CUD) has contributed to the increase in drug overdose deaths involving cocaine. This study used next-generation sequencing to identify specific genes associated with cue-evoked cocaine-seeking behavior in the medial prefrontal cortex (mPFC) of rats. The findings provide potential candidates for future pharmacotherapeutics aimed at maintaining abstinence in CUD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Jinling Chu, Satoshi Deyama, Xueting Li, Mei Motono, Atsuki Otoda, Atsushi Saito, Hirohito Esaki, Naoya Nishitani, Katsuyuki Kaneda
Summary: The study revealed that stress can enhance cocaine craving by increasing serotonin levels in the mPFC, with the 5-HT1A receptor playing a crucial role in this process, thus suggesting it as a potential therapeutic target for stress-induced cocaine craving.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Summary: Women show a faster progression, increased consumption, more positive subjective effects, and higher relapse rates during abstinence in cocaine addiction. Estradiol is a key mediator of these effects, and ERK1/2 and mTOR play a role in the underlying neurobiological mechanisms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Olga Rodriguez-Borillo, Lorena Rosello-Jimenez, Julian Guarque-Chabrera, Maria Palau-Batet, Isis Gil-Miravet, Raul Pastor, Marta Miquel, Laura Font
Summary: After cocaine exposure, increased cFos activity was observed in the granular cell layer at the top of the posterior vermis (lobules VIII and IX) in mice, and this activity was positively correlated with cFos expression in the medial prefrontal cortex. These findings suggest that certain regions of the cerebellum may be involved in the regulation of cocaine-conditioned behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Laila Asth, Lia P. Iglesias, Rayssa C. Brianis, Anna P. Marcal, Nicia P. Soares, Daniele C. Aguiar, Fabricio A. Moreira
Summary: This study examined the effects of monoamine stabilizers and aripiprazole on cocaine-induced behaviors. The results showed that aripiprazole could prevent cocaine-induced hyperlocomotion, but also impaired spontaneous locomotion, while (-)-OSU6162 had a minor effect. (-)-OSU6162 also played a role in preventing the acquisition of cocaine-induced conditioned place preference.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Elizabeth A. Birmingham, Megan M. Wickens, Julia M. Kirkland, Melissa C. Knouse, Anna G. McGrath, Lisa A. Briand
Summary: Protein interacting with C kinase 1 (PICK1) and glutamate receptor interacting protein (GRIP) regulate the number of GluA2-containing AMPARs in the synapse. Knockdown of PICK1 in male mice decreases cue-induced cocaine seeking, while knockdown of GRIP has the opposite effect. However, knockdown of either PICK1 or GRIP in female mice leads to similar increases in cue-induced cocaine seeking. This study examines the contribution of ovarian hormones to the effect of prefrontal PICK1 knockdown on cocaine seeking, showing that ovarian hormones interact with PICK1 in modulating cue-induced reinstatement.
HORMONES AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Kozlowska, Bai-Chung Shyu, Andrew Chih Wei Huang
Summary: The study aimed to re-examine the paradoxical effect hypothesis of abused drugs by investigating the impact of different doses of morphine on neuronal activity and connectivity between subareas of the medial prefrontal cortex (mPFC), subregions of the nucleus accumbens (NAc), and the basolateral amygdala (BLA) after conditioned taste aversion (CTA) and conditioned place preference (CPP) tests. The results revealed differential effects of morphine doses on c-Fos expression in various brain regions. Furthermore, correlation analysis demonstrated distinct patterns of neural connectivity between different doses of morphine and the CTA and CPP tests. These findings expand our understanding of the paradoxical effects of abused drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Estela Diaz-Sanchez, Alexander Lopez-Salas, Marina Mirchandani-Duque, Jose Erik Alvarez-Contino, Jose Andres Sanchez-Perez, Kjell Fuxe, Dasiel O. Borroto-Escuela, Natalia Garcia-Casares, Manuel Narvaez
Summary: The interaction between Neuropeptide Y (NPY) and Galanin (GAL) in specific brain regions has been implicated in neurological diseases, suggesting a potential therapeutic target for neurodegenerative and psychiatric disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Gunasingh Jeyaraj Masilamoni, Allison Weinkle, Stella M. Papa, Yoland Smith
Summary: This study found decreased serotonergic and catecholaminergic innervation in the frontal cortex at early stages of Parkinson's disease. The use of MPTP-treated monkeys as animal models revealed that these changes may contribute to early non-motor symptoms in PD.
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Biochemistry & Molecular Biology
Birgit Kaehler, Eva Viktoria Romswinkel, Mira Jakovcevski, Ashley Moses, Melitta Schachner, Fabio Morellini
Summary: Studies in humans and rodents suggest a link between impulsivity, stress response, and addiction vulnerability. NCAM deficiency in mice affects responses to cocaine, leading to enhanced sensitization, CPP, impaired extinction, and increased hyperlocomotion. NCAM-/- mice show specific behavioral alterations in response to cocaine, indicating a correlation between stress response system hyperfunction, novelty reactivity, and behavioral responses to cocaine.
Article
Pharmacology & Pharmacy
Koki Nagaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: In this study, the researchers analyzed databases to find a drug that can be used together with dopamine D2 receptor antagonists to reduce the risk of akathisia. Acetaminophen was found to be the most effective drug in suppressing tardive akathisia. Experimental validation showed that chronic treatment of rats with haloperidol caused akathisia symptoms, while acute treatment with acetaminophen significantly attenuated these symptoms.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Neurosciences
Satoshi Deyama, Katsuyuki Kaneda
Summary: The neurotrophic hypothesis of depression suggests that reduced levels of BDNF and VEGF are associated with depressive symptoms. Typical monoaminergic antidepressants can partially reverse these deficits by inducing the expression of BDNF and/or VEGF, but the effects are delayed. Ketamine, on the other hand, rapidly increases the release and/or expression of BDNF and VEGF, improving neuronal connectivity and neurogenesis, as well as leading to the sustained release of IGF-1, resulting in rapid and sustained antidepressant effects.
Article
Clinical Neurology
Satoshi Deyama, Shun Aoki, Rinako Sugie, Hayato Fukuda, Satoshi Shuto, Masabumi Minami, Katsuyuki Kaneda
Summary: The intranasal administration of RvE1, a compound with anti-inflammatory and immunomodulatory properties, has shown promising results in treating depression. This compound acts on the mPFC and dorsal DG brain regions, and its antidepressant effects are mediated by the regulation of BDNF/VEGF and mTORC1 signaling pathways.
Article
Neurosciences
Koki Nagaoka, Nozomi Asaoka, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Repeated administration of dopamine D-2 receptor antagonists for the treatment of psychosis often leads to tardive dyskinesia. This study found that activating adenosine A2A receptors in the striatum can alleviate dyskinetic symptoms caused by TD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Immunology
Keisuke Nozawa, Takahide Suzuki, Gen Kayanuma, Hiroki Yamamoto, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Recent studies have found that DPP4 inhibitors increase the risk of bullous pemphigoid (BP), a common autoimmune blistering skin disease. The mechanisms behind this association are unclear, and there are currently no identified therapeutic targets for drug-induced BP. However, clinical data mining revealed that concomitant use of lisinopril, an angiotensin-converting enzyme inhibitor, significantly decreased the incidence of BP in patients receiving DPP4 inhibitors. In vitro experiments further showed that DPP4 inhibitors upregulated MMP9 and ACE2 mRNA expression, which play a role in the pathophysiology of BP, and that lisinopril and Mas receptor inhibitors could suppress this upregulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Hiroki Yamamoto, Gen Kayanuma, Takuya Nagashima, Chihiro Toda, Kazuki Nagayasu, Shuji Kaneko
Summary: This study aimed to identify methods for the early detection of a wide range of adverse drug reactions (ADRs). A data-mining approach using large-scale medical records was used, and association rule mining (ARM) was applied to patient symptoms and medications. The results showed that ARM of claims data may be effective in the early detection of a wide range of ADR signals.
Article
Biochemistry & Molecular Biology
Shiori Yamashita, Naoki Dozono, Shota Tobori, Kazuki Nagayasu, Shuji Kaneko, Hisashi Shirakawa, Hiroshi Ueda
Summary: Abnormalities in the peripheral immune system are involved in the pathophysiology of fibromyalgia, and the activation of peripheral beta 2-adrenergic receptors plays an important role in the efferent pathway from the CNS to splenocytes in pain development. The administration of selective beta 2-blockers prevented the development but not the maintenance of pain-like behavior, and beta 2-blockade in donor mice eliminated pain reproduction in recipient mice injected with AcGP splenocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yuma Nagai, Yuri Kisaka, Kento Nomura, Naoya Nishitani, Chihiro Andoh, Masashi Koda, Hiroyuki Kawai, Kaoru Seiriki, Kazuki Nagayasu, Atsushi Kasai, Hisashi Shirakawa, Takanobu Nakazawa, Hitoshi Hashimoto, Shuji Kaneko
Summary: Major depressive disorder (MDD) is a common mental illness, and serotonergic neurons play a crucial role in its pathophysiology and treatment. Recalling positive memories repeatedly is effective for MDD. This study found that activating 5-HT neurons can activate specific neuronal ensembles associated with positive memories, providing insights into the antidepressive effects of serotonin.
Article
Pharmacology & Pharmacy
Zijian Zhou, Takuya Nagashima, Chihiro Toda, Mone Kobayashi, Takahide Suzuki, Kazuki Nagayasu, Hisashi Shirakawa, Satoshi Asai, Shuji Kaneko
Summary: Olanzapine is an atypical antipsychotic drug used for schizophrenia. Vitamin D has been found to reduce the risk of olanzapine-induced dyslipidemia. By analyzing clinical data and conducting experiments, it was discovered that vitamin D improves dyslipidemia by inhibiting cholesterol biosynthesis. This clinical big-data-based drug repurposing approach provides a novel treatment with high clinical predictability and a well-defined molecular mechanism.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Haruka Furuta, Mari Yamada, Takuya Nagashima, Shuichi Matsuda, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: The short-term use of dexamethasone prevents fluoroquinolone-induced and age-related tendinopathy by suppressing oxidative stress through upregulation of the antioxidant enzyme glutathione peroxidase 3 (GPX3).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Satoshi Deyama, Rinako Sugie, Masaki Tabata, Katsuyuki Kaneda
Summary: Tomatidine and tomatine exerted prophylactic and therapeutic antidepressant-like effects via mTORC1 activation in the mPFC, making them promising candidates for novel prophylactic and therapeutic agents for depression.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Zijian Zhou, Kazuki Nagayasu, Hisashi Shirakawa, Shuji Kaneko
Summary: Low concentrations of bortezomib (BTZ) can induce changes in peripheral nervous system cells, including dedifferentiation of Schwann cells, increased GFAP levels in satellite glial cells, and decreased expression levels of sensor and transducer ion channels in dorsal root ganglion neurons. These findings contribute to a better understanding of the mechanisms underlying BTZ-induced peripheral neuropathy.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Neurosciences
Satoshi Deyama, Xiao-Yuan Li, Ronald S. Duman
Summary: This study found that neuronal VEGF-Flk-1 signaling contributes to the antidepressant-like effects of conventional antidepressants.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Kazuki Nagayasu, Chihiro Andoh, Hisashi Shirakawa, Shuji Kaneko
Summary: In this study, a novel method for genome-wide functional screening of enhancer activity in vivo with minimal handling was described. The method allows identification of enhancers with cell-type specific and brain-structure specific activity, which is helpful for cell-type specific manipulations.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Respiratory System
Koji Kuronuma, Natsumi Susai, Tomohiro Kuroita, Hiroki Yamamoto, Takeshi Yoshioka, Shuji Kaneko, Hirofumi Chiba
Summary: This study found that PFD may cause pellagra or pellagra-like symptoms such as photosensitivity. Experiments on mice confirmed this hypothesis and suggested that it may be mediated by the actions of NNMT. Urine analysis also supported this hypothesis.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.