Article
Neurosciences
Marzena Stefaniuk, Monika Pawlowska, Marcin Baranski, Klaudia Nowicka, Zbigniew Zielinski, Lukasz Bijoch, Diana Legutko, Piotr Majka, Sylwia Bednarek, Natalia Jermakow, Daniel Wojck, Leszek Kaczmarek
Summary: Many fundamental questions on alcohol use disorder (AUD) should be examined from the perspective of the whole brain, rather than focusing on a single brain structure. By studying c-Fos expression in a mouse model, researchers have identified changes in brain functional networks caused by alcohol drinking and reexposure. These findings suggest potential targets for pharmacotherapy and highlight the importance of understanding the networks and modules involved in addiction development.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Substance Abuse
Antonia M. Savarese, Angela R. Ozburn, Amanda M. Barkley-Levenson, Pamela Metten, John C. Crabbe
Summary: The High Drinking in the Dark mouse lines (HDID-1 and HDID-2) were selectively bred for high blood ethanol concentrations. Through a series of experiments, it was found that the lack of choice and the length of ethanol access are important factors contributing to high ethanol intake in HDID mice.
Letter
Medicine, General & Internal
Jeffrey T. Howard, Jessica K. Perrotte, Kassandra Flores, Caleb Leong, Joseph David Nocito, Krista J. Howard
Summary: This cross-sectional study examines the prevalence trends of binge drinking and heavy alcohol consumption among pregnant women and nonpregnant women from 2011 to 2020.
Article
Neurosciences
Sonia Aroni, Rosa A. M. Marino, Kasey S. Girven, James M. Irving, Joseph F. Cheer, Dennis R. Sparta
Summary: Binge ethanol drinking is a major financial burden in the United States and leads to significant neuroplasticity changes in the brain. Corticotropin releasing factor (CRF) neurons in the central amygdala are believed to play a key role in modulating binge drinking. Research shows that these neurons exhibit diverse responses and enhanced electrical activity during binge drinking sessions.
Article
Substance Abuse
Leandro Ruiz Leyva, Agustin Salguero, Miriam Beatriz Virgolini, Veronica Leonor Romero, Leonardo Marengo, Maria Carolina Fabio, Ignacio Moron, Cruz Miguel Cendan, Ricardo Marcos Pautassi
Summary: The study reveals a significant interaction between adolescent ethanol exposure and binge eating behavior in female rats, leading to increased ethanol consumption. This finding provides valuable insights into the underlying mechanisms of alcohol intake and the long-term consequences of binge drinking.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Multidisciplinary Sciences
Jonathan K. Gore-Langton, Elena Varlinskaya, David F. Werner
Summary: Individuals who start drinking alcohol at a young age and engage in binge drinking during adolescence are more likely to develop alcohol use disorder. Adolescents are less sensitive to the adverse effects of alcohol and tend to consume more alcohol per occasion than adults. This insensitivity may promote higher alcohol intake in adolescents by reducing internal cues that inhibit consumption. A loss of sensitivity to the aversive effects of alcohol is associated with a disrupted insular-prefrontal cortex-accumbens core circuit.
Article
Substance Abuse
Meera Rath, Jasmin Tawfic, Aziza Abrorkhujaeva, Sam Sowell, Sara Wu, Shainnel O. Eans, Joanna Peris, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu
Summary: The study successfully modeled acute movement impairments and anxiety-like behaviors in mice after binge ethanol consumption using a modified drinking-in-the-dark model. The individual mice's ethanol intake positively correlated with blood ethanol concentration levels.
Article
Biochemistry & Molecular Biology
Pierre Sauton, Chloe Deschamps, Virginie Jeanblanc, Olivier Pierrefiche, Jerome Jeanblanc, Mickael Naassila
Summary: The study found that Long-Evans rats consumed the most ethanol in the BD model, while Wistar rats consumed the least and Sprague-Dawley rats consumed an intermediate amount. Additionally, Long-Evans rats displayed increased sensitivity to the deleterious effects of BD on hippocampal synaptic plasticity under acute ethanol exposure.
Article
Neurosciences
Nathan W. Burnham, Corryn N. Chaimowitz, Cortland C. Vis, Ana Paula Segantine Dornellas, Montserrat Navarro, Todd E. Thiele
Summary: This study found that increased NE tone in a circuit from the LC to the LH can reduce binge-like ethanol consumption in mice, providing a potential novel approach for treating binge drinking before the development of dependence.
Article
Psychology, Multidisciplinary
Maria-Teresa Cortes-Tomas, Jose-Antonio Gimenez-Costa, Patricia Motos-Selles, Maria-Dolores Sancerni-Beitia
Summary: This study analyzes the motives, expectancies, and consequences of alcohol use among college women, particularly in relation to binge drinking. The results highlight the importance of social motives and positive expectancies in predicting binge drinking behavior. Women with high-risk consequences have a significantly higher probability of engaging in binge drinking compared to those with low-risk consequences.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Chemistry, Medicinal
Bruno Goncalves Pinheiro, Diandra Araujo Luz, Sabrina de Carvalho Cartagenes, Luanna de Melo Pereira Fernandes, Sarah Viana Farias, Natalia Harumi Correa Kobayashi, Eneas Andrade Fontes-Junior, Samira G. Ferreira, Rodrigo A. Cunha, Rui Daniel Prediger, Cristiane do Socorro Ferraz Maia
Summary: This review comprehensively discusses the role of the adenosinergic system in emotional and cognitive disturbances induced by alcohol consumption during adolescence, and explores the potential benefits of caffeine as a non-selective antagonist of adenosine receptors.
Article
Biochemistry & Molecular Biology
Beatriz Rodrigues Risuenho Peinado, Walessa Alana Braganca Aragao, Cristian dos Santos Pereira, Diane Cleydes Baia da Silva, Railson de Oliveira Ferreira, Antonio Hernandes Chaves-Neto, Luanna Melo Pereira Fernandes, Rafael Rodrigues Lima
Summary: This study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. The results showed that moderate physical exercise can significantly recover antioxidant activity, reducing the damage caused by ethanol.
Article
Neurosciences
Rosa A. M. Marino, Kasey S. Girven, Antonio Figueiredo, Jovana Navarrete, Carolyn Doty, Dennis R. Sparta
Summary: Changes in brain regions involved in reward-seeking may contribute to persistent behaviors associated with alcohol-use disorder. The BNST is a critical node linked to alcohol consumption and anxiety-related disorders. Previous research suggests that the IC-vBNST projection is important in emotional and reward-seeking processes.
Article
Geriatrics & Gerontology
Tassiane C. S. Paula, Camila Chagas, Amanda E. G. Henrique, Erico Castro-Costa, Maria Fernanda Lima-Costa, Cleusa P. Ferri
Summary: This study found a high prevalence of heavy drinking and binge drinking behaviors among older Brazilians, particularly among males, those with higher education, and in the younger age groups. All drinking patterns were associated with similar factors, including being male, younger, having higher education, tobacco smoking, and falls. Additionally, a higher number of chronic diseases was linked to lower prevalence of current drinking and binge drinking.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychology, Developmental
Samuel A. J. Lowe, Sujan Basnet, Scott T. Leatherdale, Karen A. Patte, Roman Pabayo
Summary: Purpose: This study aims to examine the association between income inequality and alcohol consumption and abuse among junior high and high school students. The findings suggest a significant association between income inequality and alcohol consumption, but no significant association with current alcohol abuse among adolescents.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.