Review
Behavioral Sciences
Paul J. Fitzgerald
Summary: Major depressive disorder (MDD) continues to be a significant public health issue globally. While drugs that boost monoamines have shown antidepressant properties, there is also evidence that drugs reducing monoaminergic transmission may have antidepressant-like behavioral effects. It remains to be determined whether these drugs are effective antidepressants in human subjects.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Anthony M. Downs, Zoe A. McElligott
Summary: This review discusses recent advances in understanding the role of the noradrenergic system in substance use disorders, including potential therapeutic targets and new treatment approaches.
Article
Endocrinology & Metabolism
Agustin Benitez, Raul Riquelme, Miguel del Campo, Camila Araya, Hernan E. Lara
Summary: The study finds that NGF may be one of the main regulators of the ovary, suggesting its role in the cholinergic system of the ovary as well.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaojing Zhai, Dongyu Zhou, Yi Han, Ming-Hu Han, Hongxing Zhang
Summary: Resilience is an active adaption process in response to adversity, trauma, tragedy, threats, or stress. The neurobiological mechanisms of resilience have provided new insights for preclinical research and drug development for stress-related disorders. The locus coeruleus norepinephrine system plays a key role in mediating stress susceptibility versus resilience and has gained significant attention in recent years. This review article discusses resilience-related concepts, rodent paradigms for studying susceptibility and resilience, recent findings on neuronal and molecular substrates of active resilience in the locus coeruleus, and potential future directions for resilience research.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Nathan W. Burnham, Corryn N. Chaimowitz, Cortland C. Vis, Ana Paula Segantine Dornellas, Montserrat Navarro, Todd E. Thiele
Summary: This study found that increased NE tone in a circuit from the LC to the LH can reduce binge-like ethanol consumption in mice, providing a potential novel approach for treating binge drinking before the development of dependence.
Article
Neurosciences
Ana Paula S. Dornellas, Nathan W. Burnham, Kendall L. Luhn, Maxwell Petruzzi, Todd E. Thiele, Montserrat Navarro
Summary: There is evidence showing that ethanol has aversive effects that reduce consumption. The study found that the LC to RMTg pathway plays a key role in modulating ethanol intake.
Article
Biochemistry & Molecular Biology
Alejandro Osorio-Forero, Romain Cardis, Gil Vantomme, Aurelie Guillaume-Gentil, Georgia Katsioudi, Christiane Devenoges, Laura M. J. Fernandez, Anita Luthi
Summary: During NREMS, fluctuation of noradrenaline levels in thalamus are associated with sleep spindle rhythms and heart-rate variations, indicating vigilance-promoting mechanism by LC neurons. Optogenetic activation or inhibition of LC neurons can modulate sleep-spindle clustering and heart-rate variations, affecting sensory arousability during NREMS. Noradrenergic modulation of thalamic circuits plays a key role in maintaining sensory arousability in mammalian NREMS.
Article
Neurosciences
Theodoros Tsetsenis, Julia K. Badyna, Rebecca Li, John A. Dani
Summary: Processing of contextual information is crucial for learning and memory. This study demonstrates that increasing noradrenergic activity in the hippocampus enhances contextual associative learning, and this effect requires activation of specific receptors. Additionally, it shows that increasing norepinephrine release can ameliorate contextual fear learning impairments caused by dopaminergic dysregulation in the hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Antonio Malvasi, Antonella Vimercati, Ilaria Ricci, Nico Picardi, Ettore Cicinelli, Ioannis Kosmas, Giorgio Maria Baldini, Andrea Tinelli
Summary: This study investigated the changes in catecholaminergic neurotransmitters in the lower uterine segment during prolonged labor with different fetal positions. The reduction of these neurotransmitters was found to negatively interfere with uterine contraction during labor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Simone R. Potje, Ayman Isbatan, Rita C. Tostes, Lusiane M. Bendhack, Randal O. Dull, Joao L. Carvalho-de-Souza, Andreia Z. Chignalia
Summary: The study demonstrated that glypican 1 plays a crucial role in the development of noradrenergic hypertension by acting through IP3R and calcium-dependent signaling pathways. Knockout mice lacking glypican 1 were uniquely protected from a norepinephrine hypertensive challenge, indicating its potential as a target for new therapies for resistant hypertension or conditions with increased norepinephrine levels.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Xiaoyi Lin, Daoming Zhu, Kaiyang Wang, Pengbo Luo, Gang Rui, Youshui Gao, Fuan Liu, Hongping Yu
Summary: Activated ALDH 2 has been demonstrated to have a protective role in ethanol-induced ONFH by promoting new bone formation, reducing adipogenesis, and stimulating vascularization.
CELL PROLIFERATION
(2022)
Article
Clinical Neurology
Michael A. Urbin, Charles W. Lafe, Tyler W. Simpson, George F. Wittenberg, Bharath Chandrasekaran, Douglas J. Weber
Summary: The study investigated the acute pupillary responses elicited by transcutaneous stimulation of the external ear, finding that stimulation at different locations can provoke such responses, with effects influenced by pulse amplitude and frequency. Further research is needed to distinguish the roles of vagal and non-vagal afferents in mediating biomarker activation.
Article
Neurosciences
Fei Zeng, Yan Fan, Russell W. Brown, Wesley Drew Gill, Jennifer B. Price, Thomas C. Jones, Meng-Yang Zhu
Summary: This study found that enhancing noradrenergic activity in the brain can improve the function of dopaminergic neurons in aged animals, potentially indicating biochemical therapeutic benefits but not necessarily behavioral improvements.
Article
Neurosciences
Angelica Salinas-Birt, Xiangyu Zhu, Eunice Y. Lim, Aryana J. Cruz J. Santory, Liang Ye, Martin Paukert
Summary: Behavioral state plays an important role in astroglia Ca2+ signaling, with locomotion-induced vigilance triggering norepinephrine-dependent Ca2+ elevations. The speed of locomotion has little effect on Ca2+ signals, but prolonged locomotion events result in steady-state Ca2+ elevation. Coordinated activity among noradrenergic terminals determines Bergmann glia Ca2+ activity.
Article
Neurosciences
Dong-oh Seo, Eric T. Zhang, Sean C. Piantadosi, David J. Marcus, Laura E. Motard, Bryce K. Kan, Adrian M. Gomez, Tammy K. Nguyen, Li Xia, Michael R. Bruchas
Summary: The study found that the activation of noradrenergic neurons can lead to contextual generalization, which requires b-adrenergic-mediated modulation to promote aversive generalization. This suggests that disruption of noradrenergic tone may be an important avenue for treating stress-induced disorders.
Article
Substance Abuse
Atefeh Bakhtazad, Afsaneh Asgari Taei, Fatemeh Parvizi, Mehdi Kadivar, Maryam Farahmandfar
Summary: This study found that repeated morphine pretreatment can reverse the impairment of spatial learning and memory caused by ethanol, and this effect may be explained by the modulation of CaMKII and BDNF expressions in the hippocampus and amygdala.