Article
Behavioral Sciences
Prableen K. Singh, Kabirullah Lutfy
Summary: The study found differences in cocaine-induced conditioned place preference (CPP) between male and female mice lacking beta-endorphin, with gender-related distinctions in CPP reinstatement. The results suggest a functional role for beta-endorphin in cocaine-induced CPP and reinstatement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Gabrielle M. Henriques, Alexia Anjos-Santos, Isa R. S. Rodrigues, Victor Nascimento-Rocha, Henrique S. Reis, Matheus Libarino-Santos, Thaisa Barros-Santos, Thais S. Yokoyama, Natalia B. Bertagna, Cristiane A. Favoretto, Celia R. G. Moraes, Fabio C. Cruz, Paulo C. R. Barbosa, Eduardo A. Marinho, Alexandre J. Oliveira-Lima, Lais F. Berro
Summary: Ibogaine may have therapeutic properties for the treatment of alcohol use disorder without having rewarding effects per se. The study results show that ibogaine can block the reinstatement of ethanol-induced CPP, suggesting its potential as a treatment option for alcohol use disorder.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Francisco Rodenas-Gonzalez, Maria del Carmen Blanco-Gandia, Maria Pascual, Irene Molari, Consuelo Guerri, Jose Minarro Lopez, Marta Rodriguez-Arias
Summary: Studies suggest that consuming high-fat foods may decrease vulnerability to drug abuse, and limiting exposure to high-fat diets during extinction and reinstatement processes can be beneficial in reducing cocaine-induced reinstatement. Additionally, gender differences may exist in the effects of fat consumption on drug-related memories.
PSYCHOPHARMACOLOGY
(2021)
Article
Plant Sciences
Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Shu
Summary: The study found that processed Aconiti tuber (PAT) shortens the extinction of morphine-induced CPP when administered before CPP formation, but extends the extinction when administered after CPP acquisition. PAT has no effect on the reinstatement of CPP. The dynorphin concentration in the nucleus accumbens increases with PAT administration.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Federica Fugazzotto, Francesco Occhiuto, Maria P. Garcia-Pardo, Maria A. Aguilar
Summary: Hypericum perforatum L. shows positive effects in reducing the rewarding effects of cocaine and preventing stress-induced reinstatement of cocaine CPP in mice. These results support the potential of Hypericum as a natural treatment for cocaine dependence.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Caibing Gao, Hua Guo, Tao Sun, Feng Wang
Summary: This study investigates the potential effects of GLP-1R agonist Ex4 on cocaine relapse behaviors and finds that Ex4 can attenuate cocaine- and stress-induced reinstatement of conditioned place preference (CPP). Furthermore, Ex4 normalizes the expression of NF-kappa beta, which is upregulated by cocaine. These findings suggest that GLP-1R agonists have promising potential in the treatment of cocaine use disorder.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Adel Kashefi, Carlos Tomaz, Shole Jamali, Ali Rashidy-Pour, Abbas Ali Vafaei, Abbas Haghparast
Summary: The study showed that CBD administration had a significant impact on extinction and reinstatement of MPH-induced conditioning place preference (CPP) in rats, suggesting its potential as a method to alleviate symptoms of drug addiction.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen
Summary: The study demonstrates that simvastatin can prevent the reinstatement of cocaine-induced conditioned place preference without affecting its acquisition, likely due to its administration during extinction phase. Lipidomic analysis reveals that the nucleus accumbens is the most affected brain region by simvastatin, with alterations in fatty acids, phospholipids, and triacylglycerol metabolism. Simvastatin reverses most effects on phospholipids induced by cocaine and reshapes lipid metabolic pathways in specific brain regions, ultimately facilitating cocaine extinction and preventing relapse.
NEUROSCIENCE BULLETIN
(2021)
Article
Behavioral Sciences
Andleeb Shahzadi, Oruc Yunusoglu, Enes Karabulut, Haktan Sonmez, Zeliha Yazici
Summary: The present study aimed to investigate the effects of ropinirole D2/3 agonist on the rewarding and reinforcing properties of morphine. The results showed that ropinirole attenuated the conditioned place preference (CPP) and reinstatement of morphine, while leading to the extinction of morphine-induced CPP. Ropinirole also alleviated naloxone-precipitated morphine withdrawal symptoms, although increased jumping behavior. Thus, ropinirole influences the dopaminergic system to reduce drug seeking and weaken reinstatement, showing its potential in attenuating dependence.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Claudia Calpe-Lopez, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares, Jose Minarro, Maria A. Aguilar
Summary: The study found that CBD may reduce reinstatement of seeking cocaine in mice, and CBD itself does not induce reinstatement but can block the reinstating effects of cocaine priming and social defeat. Furthermore, cocaine priming increased the gene expression of DAT in the ventral tegmental area, which was completely reversed by CBD.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Arlene Martinez-Rivera, Jin Hao, Richard Rice, Charles E. Inturrisi, Anjali M. Rajadhyaksha
Summary: In this study, the researchers demonstrated that Cav1.3 channels in the ventral tegmental area (VTA) are required for cocaine reward behavior. They also found that the CaMKII alpha/ERK/CREB signaling pathway in the VTA is necessary for long-lasting changes in the nucleus accumbens (NAc) following cocaine conditioned place preference (CPP).
Article
Neurosciences
Jialing Cai, Xiaohang Che, Tianyu Xu, Yuanchao Luo, Meixue Yin, Xianda Lu, Chunfu Wu, Jingyu Yang
Summary: Repeated OXT treatment during abstinence inhibits both context-and restraint stress-induced METH-CPP reinstatement and promotes AHN in mice. Further evidence suggests that AHN is closely involved in mediating OXT's inhibitory effects on reinstatement induced by both triggers. This study provides valuable insights into the mechanisms underlying OXT's beneficial effects on METH addiction.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Behavioral Sciences
Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Summary: Women show a faster progression, increased consumption, more positive subjective effects, and higher relapse rates during abstinence in cocaine addiction. Estradiol is a key mediator of these effects, and ERK1/2 and mTOR play a role in the underlying neurobiological mechanisms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Oruc Yunusoglu
Summary: Nicotine addiction poses a significant burden on global public health and economy. Resveratrol has positive effects on drug addiction and substance addiction, inhibiting the reward properties and reinstatement of nicotine. It could be beneficial as an adjuvant pharmacotherapy for nicotine addiction.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Neurosciences
Jordan A. Brown, Nicholas Petersen, Samuel W. Centanni, Allie Y. Jin, Hye Jean Yoon, Stephanie A. Cajigas, Michelle N. Bedenbaugh, Joseph R. Luchsinger, Sachin Patel, Erin S. Calipari, Richard B. Simerly, Danny G. Winder
Summary: Alpha(2a)-adrenergic receptor agonists have the potential to be therapeutics for substance use disorder due to their ability to regulate stress system engagement. However, recent findings suggest that postsynaptic alpha(2a)-ARs are necessary for stress-induced reinstatement of drug-seeking behavior. In this study, the researchers utilized FosTRAP mice to identify a population of cells in the bed nucleus of the stria terminalis that are activated by the partial agonist guanfacine. They found that these cells, called Guansembles, differ from cells activated by restraint stress. Guanfacine inhibited cAMP-dependent signaling in Guansembles, while chronic restraint stress increased signaling. Additionally, the researchers found that active coping events during restraint stress and exposure to unexpected shocks were associated with Guansemble recruitment. Using viral tracing, they identified a network of regions involved in stress and homeostatic functions that project to the BNST Guansembles. Activation of Guansembles also produced alterations in behavior consistent with task-specific anxiety-like behavior. Overall, this study provides important insights into the role of alpha(2a)-AR signaling and stress in regulating drug-seeking behavior.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nicholas A. Harris, Danny G. Winder
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Neurosciences
Nicholas A. Harris, Austin T. Isaac, Anne Guenther, Kevin Merkel, James Melchior, Michelle Xu, Eghosa Eguakun, Rafael Perez, Brett P. Nabit, Stephanie Flavin, Ralf Gilsbach, Brian Shonesy, Lutz Hein, Ted Abel, Arnd Baumann, Robert Matthews, Samuel W. Centanni, Danny G. Winder
JOURNAL OF NEUROSCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Amelia B. Hadler, Nicholas A. Harris, Daniel C. Fredrickson
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2013)
Article
Chemistry, Inorganic & Nuclear
Nicholas A. Harris, Amelia B. Hadler, Daniel C. Fredrickson
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2011)
Article
Biochemistry & Molecular Biology
Zack Zurawski, Analisa D. Thompson Gray, Lillian J. Brady, Brian Page, Emily Church, Nicholas A. Harris, Michael R. Dohn, Yun Young Yim, Karren Hyde, Douglas P. Mortlock, Carrie K. Jones, Danny G. Winder, Simon Alford, Heidi E. Hamm
Article
Neurosciences
Max E. Joffe, Chiaki I. Santiago, Kendra H. Oliver, James Maksymetz, Nicholas A. Harris, Julie L. Engers, Craig W. Lindsley, Danny G. Winder, P. Jeffrey Conn
Meeting Abstract
Substance Abuse
O. Vranjkovic, A. A. Jaramillo, S. W. Centanni, N. A. Harris, D. G. Winder
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2018)