The role of mitochondrial fission in cardiovascular health and disease

DRP1 interacts directly with BAX to induce its activation and apoptosis

(2022) Andreas Jenner et al.   EMBO JOURNAL

Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion

(2021) Maximillian A Rogers et al.   CARDIOVASCULAR RESEARCH

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

(2021) Mohamed Bekhite et al.   FREE RADICAL BIOLOGY AND MEDICINE

High glucose induces Drp1-mediated mitochondrial fission via the Orai1 calcium channel to participate in diabetic cardiomyocyte hypertrophy

(2021) Qing-Rui Wu et al.   Cell Death & Disease

Pharmacological advances in mitochondrial therapy

(2021) Aarti Singh et al.   EBioMedicine

Distinct fission signatures predict mitochondrial degradation or biogenesis

(2021) Tatjana Kleele et al.   NATURE

Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy

(2021) Yung Ting Hsiao et al.   Scientific Reports

A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression

(2021) Evanthia Pangou et al.   Cell Reports

Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation

(2021) Grigor Varuzhanyan et al.   DEVELOPMENT

ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division

(2021) Maxime Boutry et al.   Nature Communications

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation

(2021) Miriam Valera-Alberni et al.   Cell Reports

Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport

(2021) Aaron Ramonett et al.   MOLECULAR BIOLOGY OF THE CELL

The assembly, regulation and function of the mitochondrial respiratory chain

(2021) Irene Vercellino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2

(2021) Chenyang Duan et al.   Cell Death & Disease

Exercise Enhanced Cardiac Function in Mice With Radiation-Induced Heart Disease via the FNDC5/Irisin-Dependent Mitochondrial Turnover Pathway

(2021) Wuyang He et al.   Frontiers in Physiology

Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy

(2020) Yi Zhu et al.   APOPTOSIS

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

(2020) Tyler M. Bauer et al.   CIRCULATION RESEARCH

Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction

(2020) Qingxun Hu et al.   CIRCULATION RESEARCH

Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm

(2020) Hannah A Cooper et al.   CARDIOVASCULAR RESEARCH

Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II

(2020) Masashi Miyao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway

(2020) Wei Ren Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Golgi-derived PI(4)P-containing vesicles drive late steps of mitochondrial division

(2020) Shun Nagashima et al.   SCIENCE

Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury

(2020) Ryuta Umezu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission

(2020) Xinyue Liang et al.   PHARMACOLOGICAL RESEARCH

Crocetin Attenuates Sepsis-Induced Cardiac Dysfunction via Regulation of Inflammatory Response and Mitochondrial Function

(2020) Yanpeng Wang et al.   Frontiers in Physiology

Downregulation of Drp1 and Fis1 Inhibits Mitochondrial Fission and Prevents High Glucose-Induced Apoptosis in Retinal Endothelial Cells

(2020) Dongjoon Kim et al.   Cells

Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise

(2020) Alexandra G. Moyzis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

(2020) Li‐Ming Yu et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial Fusion: The Machineries In and Out

(2020) Song Gao et al.   TRENDS IN CELL BIOLOGY

Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes

(2020) Richa Aishwarya et al.   Redox Biology

AMPKα2 Overexpression Reduces Cardiomyocyte Ischemia-Reperfusion Injury Through Normalization of Mitochondrial Dynamics

(2020) Yuanyan Deng et al.   Frontiers in Cell and Developmental Biology

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

(2020) Siavash Beikoghli Kalkhoran et al.   CARDIOVASCULAR RESEARCH

Vitamin D Attenuates Ischemia/Reperfusion-Induced Cardiac Injury by Reducing Mitochondrial Fission and Mitophagy

(2020) Tzu-Lin Lee et al.   Frontiers in Pharmacology

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

(2019) Bereketeab Haileselassie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac fibrosis – A short review of causes and therapeutic strategies

(2019) Svenja Hinderer et al.   ADVANCED DRUG DELIVERY REVIEWS

Lysophosphatidylcholine-induced mitochondrial fission contributes to collagen production in human cardiac fibroblasts

(2019) Hui-Ching Tseng et al.   JOURNAL OF LIPID RESEARCH

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

(2019) Sang-Bing Ong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial fusion mediated by fusion promotion and fission inhibition directs adult mouse heart function toward a different direction

(2019) Yuan Qin et al.   FASEB JOURNAL

The phosphorylation status of Ser-637 in dynamin-related protein 1 (Drp1) does not determine Drp1 recruitment to mitochondria

(2019) Rong Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

(2019) Danchen Wu et al.   FASEB JOURNAL

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Involvement of mitochondrial fission in calcium sensing receptor-mediated vascular smooth muscle cells proliferation during hypertension

(2018) Xin Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide

(2018) Hani N. Sabbah et al.   CARDIOVASCULAR DRUGS AND THERAPY

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

(2018) Andrew L Durham et al.   CARDIOVASCULAR RESEARCH

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension

(2018) Kuang-Hueih Chen et al.   CIRCULATION

Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats

(2018) Prottoy Hasan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes

(2018) Bong Sook Jhun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis

(2018) Yvette C. Wong et al.   NATURE

Nitric oxide signalling in cardiovascular health and disease

(2018) Charlotte Farah et al.   Nature Reviews Cardiology

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

S-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

(2018) Salvatore Rizza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence

(2018) Young-Mee Kim et al.   Cell Reports

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation–Induced Cardiac Proteotoxicity

(2018) Shafiul Alam et al.   Journal of the American Heart Association

Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

(2018) Jia Qi et al.   Frontiers in Pharmacology

Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

(2018) Lian Tian et al.   Frontiers in Physiology

Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission

(2018) Hao Zhou et al.   Redox Biology

Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons

(2018) Duk-shin Lee et al.   Cell Death & Disease

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo

(2018) Opher S. Kornfeld et al.   Scientific Reports

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia

(2018) Toshiro Saito et al.   JOURNAL OF CLINICAL INVESTIGATION

Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System

(2018) Hyo Min Cho et al.   MOLECULAR CELL

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process

(2018) Åsa B. Gustafsson et al.   PHYSIOLOGICAL REVIEWS

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission–associated myocardial senescence

(2018) Akiyuki Nishimura et al.   Science Signaling

Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming

(2018) Luca Simula et al.   Cell Reports

Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response

(2018) Farhan Basit et al.   Frontiers in Immunology

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

(2018) Timothy M. Moore et al.   Molecular Metabolism

Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease

(2018) A.U. Joshi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division

(2017) Rajarshi Chakrabarti et al.   JOURNAL OF CELL BIOLOGY

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

(2017) Wei-Ke Ji et al.   JOURNAL OF CELL BIOLOGY

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission

(2017) Lei Cui et al.   VASCULAR PHARMACOLOGY

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

(2017) Babette C. Hammerling et al.   Nature Communications

Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability

(2017) Zhengjun Gao et al.   Nature Communications

Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division

(2017) Bongki Cho et al.   Nature Communications

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

(2017) Chun Guo et al.   Scientific Reports

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

(2017) Hao Zhou et al.   Journal of the American Heart Association

Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand

(2017) Michael Coronado et al.   CIRCULATION RESEARCH

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission

(2017) Kensuke Tsushima et al.   CIRCULATION RESEARCH

S-Nitrosylation of DRP1 Does Not Affect Enzymatic Activity and is Not Specific to Alzheimer's Disease

(2017) Blaise Bossy et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

(2016) Björn Oettinghaus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration

(2016) Huiliang Zhang et al.   CARDIOVASCULAR RESEARCH

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

(2016) Shun-ichi Yamashita et al.   JOURNAL OF CELL BIOLOGY

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

(2016) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

(2016) Shangcheng Xu et al.   Nature Communications

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia

(2015) Li Wang et al.   CARDIOVASCULAR RESEARCH

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

(2015) Moshi Song et al.   Cell Metabolism

Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse HeartsNovelty and Significance

(2015) Moshi Song et al.   CIRCULATION RESEARCH

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

(2015) Lixiang Wang et al.   DIABETOLOGIA

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure

(2015) Thomas J. Cahill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Titration of mitochondrial fusion rescuesMff-deficient cardiomyopathy

(2015) Hsiuchen Chen et al.   JOURNAL OF CELL BIOLOGY

MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death

(2015) Julien Prudent et al.   MOLECULAR CELL

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

(2015) T Touvier et al.   Cell Death & Disease

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

(2014) Ramiro Zepeda et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Dynamics of Mitochondrial DNA Nucleoids Regulated by Mitochondrial Fission Is Essential for Maintenance of Homogeneously Active Mitochondria during Neonatal Heart Development

(2014) Takaya Ishihara et al.   MOLECULAR AND CELLULAR BIOLOGY

Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death

(2013) Valentina Parra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

(2013) Chris Fröhlich et al.   EMBO JOURNAL

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

Calcification as a Risk Factor for Rupture of Abdominal Aortic Aneurysm

(2013) R.V.C. Buijs et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Quantitative Phosphoproteomic Study of Pressure-Overloaded Mouse Heart Reveals Dynamin-Related Protein 1 as a Modulator of Cardiac Hypertrophy

(2013) Yu-Wang Chang et al.   MOLECULAR & CELLULAR PROTEOMICS

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

(2013) Qinfang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c

(2013) R. Ban-Ishihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Mitofusins 1 and 2 Are Essential for Postnatal Metabolic Remodeling in Heart

(2012) Kyriakos N. Papanicolaou et al.   CIRCULATION RESEARCH

Transgenic Control of Mitochondrial Fission Induces Mitochondrial Uncoupling and Relieves Diabetic Oxidative Stress

(2012) C. A. Galloway et al.   DIABETES

Modulation of Dynamin-related Protein 1 (DRP1) Function by IncreasedO-linked-β-N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

(2012) Thomas Gawlowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Regulation byS-Nitrosylation of Protein Post-translational Modification

(2011) Douglas T. Hess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RALA and RALBP1 regulate mitochondrial fission at mitosis

(2011) David F. Kashatus et al.   NATURE CELL BIOLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle

(2009) Claudia Figueroa-Romero et al.   FASEB JOURNAL

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

(2008) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA