Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

(2019) Sang-Bing Ong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardioprotection of hydralazine against myocardial ischemia/reperfusion injury in rats

(2019) Chengzong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

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Drugs for treating severe hypertension in pregnancy: a network meta-analysis and trial sequential analysis of randomized clinical trials

(2018) Kannan Sridharan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Hydralazine protects against renal ischemia-reperfusion injury in rats

(2018) Yong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury–to–chronic kidney disease progression

(2017) Björn Tampe et al.   KIDNEY INTERNATIONAL

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

(2017) Verónica Eisner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mdivi-1 Protects Human W8B2+ Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury

(2017) Ayeshah A. Rosdah et al.   STEM CELLS AND DEVELOPMENT

High glucose concentration abrogates sevoflurane post-conditioning cardioprotection by advancing mitochondrial fission but dynamin-related protein 1 inhibitor restores these effects

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A novel fission-independent role of dynamin-related protein 1 in cardiac mitochondrial respiration

(2016) Huiliang Zhang et al.   CARDIOVASCULAR RESEARCH

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

Reduction of no-reflow and reperfusion injury with the synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade

(2015) Sauri Hernández-Reséndiz et al.   BASIC RESEARCH IN CARDIOLOGY

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

(2015) Sang-Bing Ong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

(2014) Ramiro Zepeda et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Dipeptidyl peptidase-4 inhibitors and GLP-1 reduce myocardial infarct size in a glucose-dependent manner

(2013) Derek J Hausenloy et al.   Cardiovascular Diabetology

Hydralazine and Organic Nitrates Restore Impaired Excitation-Contraction Coupling by Reducing Calcium Leak Associated with Nitroso-Redox Imbalance

(2013) Raul A. Dulce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

(2013) Hilary K. Siddall et al.   PLoS One

Functional Mapping of Human Dynamin-1-Like GTPase Domain Based on X-ray Structure Analyses

(2013) Julia Wenger et al.   PLoS One

Kissing and nanotunneling mediate intermitochondrial communication in the heart

(2013) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics

(2012) Anh H. Pham et al.   GENESIS

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Inhibition of semicarbazide-sensitive amine oxidase attenuates myocardial ischemia–reperfusion injury in an in vivo rat model

(2010) Wei Yang et al.   LIFE SCIENCES

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

The novel adipocytokine visfatin exerts direct cardioprotective effects

(2008) Shiang Y. Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myocardial protection: is primary PCI enough?

(2008) Derek J Hausenloy et al.   Nature clinical practice. Cardiovascular medicine