Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

Mitochondria-Associated Endoplasmic Reticulum Membrane (MAM) Integrity Is Required for Insulin Signaling and Is Implicated in Hepatic Insulin Resistance

(2014) E. Tubbs et al.   DIABETES

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

(2014) Seong Hun Kim et al.   DIABETOLOGIA

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine

(2013) Susanne Keipert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

(2013) Kook Hwan Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

(2013) Saverio Marchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity

(2013) Masatoshi Nomura et al.   DIABETOLOGIA

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

(2013) Qinfang Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Riociguat for Pulmonary Hypertension — A Glass Half Full

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

(2013) Eric S. Muise et al.   PLoS One

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Regulation and Physiologic Functions of GTPases in Mitochondrial Fusion and Fission in Mammals

(2012) Naotada Ishihara et al.   ANTIOXIDANTS & REDOX SIGNALING

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

(2012) Frank G. Schaap et al.   BIOCHIMIE

Unfolded protein response

(2012) Stewart Siyan Cao et al.   CURRENT BIOLOGY

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

(2011) Jiansheng Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular mechanisms and physiologic functions of mitochondrial dynamics

(2011) H. Otera et al.   JOURNAL OF BIOCHEMISTRY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

(2010) f. M. Fisher et al.   DIABETES

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY