Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study

FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice

(2019) Gopala K. Yakala et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities

(2019) Ioanna Andreadou et al.   CARDIOVASCULAR RESEARCH

Role of Macrophages in Cardioprotection

(2019) Jonathan Yap et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apolipoprotein E in Cardiovascular Diseases: Novel Aspects of an Old-fashioned Enigma

(2018) Elisa A. Liehn et al.   ARCHIVES OF MEDICAL RESEARCH

Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia/reperfusion injury

(2018) Chayodom Maneechote et al.   CLINICAL SCIENCE

Innate immunity as a target for acute cardioprotection

(2018) Coert J Zuurbier et al.   CARDIOVASCULAR RESEARCH

Circulating blood cells and extracellular vesicles in acute cardioprotection

(2018) Sean M Davidson et al.   CARDIOVASCULAR RESEARCH

Mdivi-1 Protects Human W8B2+ Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury

(2017) Ayeshah A. Rosdah et al.   STEM CELLS AND DEVELOPMENT

Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance

(2017) Rachel K. Dongworth et al.   Scientific Reports

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

Inhibition of mitochondrial fission as a molecular target for cardioprotection: critical importance of the timing of treatment

(2016) Yi Dong et al.   BASIC RESEARCH IN CARDIOLOGY

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”

(2016) Hector A. Cabrera-Fuentes et al.   BASIC RESEARCH IN CARDIOLOGY

Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

(2016) Derek J. Hausenloy et al.   BASIC RESEARCH IN CARDIOLOGY

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

(2016) Derek J. Hausenloy et al.   EUROPEAN HEART JOURNAL

Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

(2016) Ayako Ishikita et al.   Journal of the American Heart Association

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside

(2015) Hector A. Cabrera-Fuentes et al.   BASIC RESEARCH IN CARDIOLOGY

The mitochondrial division inhibitor mdivi-1 attenuates spinal cord ischemia–reperfusion injury both in vitro and in vivo: Involvement of BK channels

(2015) Jian-Min Liu et al.   BRAIN RESEARCH

Inhibition of the Mitochondrial Fission Protein Dynamin-Related Protein 1 Improves Survival in a Murine Cardiac Arrest Model

(2015) Willard W. Sharp et al.   CRITICAL CARE MEDICINE

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

(2015) Sang-Bing Ong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome

(2015) M. Sumida et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting Myocardial Reperfusion Injury — The Search Continues

(2015) Derek J. Hausenloy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclosporine before PCI in Patients with Acute Myocardial Infarction

(2015) Thien-Tri Cung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism and consequences of the shift in cardiac arginine metabolism following ischaemia and reperfusion in rats

(2015) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology

(2015) Sang-Bing Ong et al.   THROMBOSIS AND HAEMOSTASIS

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1

(2014) Yan-Xin Zhao et al.   CNS Neuroscience & Therapeutics

Drp1 Loss-of-function Reduces Cardiomyocyte Oxygen Dependence Protecting the Heart From Ischemia-reperfusion Injury

(2014) Ramiro Zepeda et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mdivi-1 Prevents Apoptosis Induced by Ischemia–Reperfusion Injury in Primary Hippocampal Cells via Inhibition of Reactive Oxygen Species–Activated Mitochondrial Pathway

(2014) Jinying Wang et al.   Journal of Stroke & Cerebrovascular Diseases

Mdivi-1 Protects Against Ischemic Brain Injury via Elevating Extracellular Adenosine in a cAMP/CREB-CD39-Dependent Manner

(2014) Mei Cui et al.   MOLECULAR NEUROBIOLOGY

RNase1 prevents the damaging interplay between extracellular RNA and tumour necrosis factor-α in cardiac ischaemia/reperfusion injury

(2014) Hector Cabrera-Fuentes et al.   THROMBOSIS AND HAEMOSTASIS

DJ-1 protects against cell death following acute cardiac ischemia–reperfusion injury

(2014) R K Dongworth et al.   Cell Death & Disease

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

(2013) A R Hall et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

(2013) Willard W. Sharp et al.   FASEB JOURNAL

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

(2013) Derek J. Hausenloy et al.   JOURNAL OF CLINICAL INVESTIGATION

A selective inhibitor of Drp1, mdivi-1, acts against cerebral ischemia/reperfusion injury via an anti-apoptotic pathway in rats

(2013) Ning Zhang et al.   NEUROSCIENCE LETTERS

Small and large animal models in cardiac contraction research: Advantages and disadvantages

(2013) Nima Milani-Nejad et al.   PHARMACOLOGY & THERAPEUTICS

Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart

(2013) Danchen Gao et al.   PLoS One

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction

(2013) Marie‐Hélène Disatnik et al.   Journal of the American Heart Association

Mitochondrial Dynamics in Cardiovascular Health and Disease

(2012) Sang-Bing Ong et al.   ANTIOXIDANTS & REDOX SIGNALING

New roles for mitochondria in cell death in the reperfused myocardium

(2011) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

(2010) Shiang Y. Lim et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial biogenesis and turnover

(2008) F DIAZ et al.   CELL CALCIUM

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Pathophysiology of Myocardial Infarction

(2008) Andreas Skyschally et al.   HERZ

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

(2008) Philippe A. Parone et al.   PLoS One