Mitochondrial fusion mediated by fusion promotion and fission inhibition directs adult mouse heart function toward a different direction

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model

(2019) Yueqin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of treadmill exercise on mitochondrial fusion and fission in the hippocampus of APP/PS1 mice

(2019) Qing-Wei Yan et al.   NEUROSCIENCE LETTERS

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Downregulation of Drp1, a fission regulator, is associated with human lung and colon cancers

(2018) Young Yeon Kim et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitoflash lights single mitochondrial dynamics events in mature cardiomyocytes

(2018) Yuan Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

(2018) Amit U Joshi et al.   EMBO Molecular Medicine

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

(2018) Jianbin Bi et al.   Redox Biology

Epigallocatechin-3-gallate ameliorates hypoxia-induced pulmonary vascular remodeling by promoting mitofusin-2-mediated mitochondrial fusion

(2017) Tian-Tian Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1

(2017) Jie-Jie Zhang et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

(2017) David Sebastián et al.   TRENDS IN MOLECULAR MEDICINE

A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis

(2017) Juanjuan Zhang et al.   Scientific Reports

Mitochondrial Flash: Integrative Reactive Oxygen Species and pH Signals in Cell and Organelle Biology

(2016) Wang Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload–Induced Mitochondrial Dysfunction and Heart FailureCLINICAL PERSPECTIVE

(2016) Akihiro Shirakabe et al.   CIRCULATION

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch-independent RBPJ controls angiogenesis in the adult heart

(2016) Ramón Díaz-Trelles et al.   Nature Communications

Mitochondrial dynamism and heart disease: changing shape and shaping change

(2015) G. W. Dorn   EMBO Molecular Medicine

Titration of mitochondrial fusion rescuesMff-deficient cardiomyopathy

(2015) Hsiuchen Chen et al.   JOURNAL OF CELL BIOLOGY

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology

(2015) Sang-Bing Ong et al.   THROMBOSIS AND HAEMOSTASIS

Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy

(2014) Moshi Song et al.   CIRCULATION RESEARCH

Regulation of metabolism in individual mitochondria during excitation–contraction coupling

(2014) Guohua Gong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitofusin 2-Containing Mitochondrial-Reticular Microdomains Direct Rapid Cardiomyocyte Bioenergetic Responses Via Interorganelle Ca 2+ Crosstalk

(2012) Yun Chen et al.   CIRCULATION RESEARCH

Mitochondrial fragmentation caused by phenanthroline promotes mitophagy

(2012) So Jung Park et al.   FEBS LETTERS

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity

(2012) X. Qi et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury

(2010) Sang-Bing Ong et al.   CIRCULATION

Could successful (mitochondrial) networking help prevent Huntington's disease?

(2010) Jorge M. A. Oliveira et al.   EMBO Molecular Medicine

Crosstalk signaling between mitochondrial Ca2+ and ROS

(2009) Robert et al.   Frontiers in Bioscience-Landmark

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Calcium Elevation in Mitochondria Is the Main Ca2+Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

(2009) Heidi K. Baumgartner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

(2009) Zhiyin Song et al.   MOLECULAR BIOLOGY OF THE CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE