Nano-vectors for CRISPR/Cas9-mediated genome editing

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Microneedle-assisted genome editing: A transdermal strategy of targeting NLRP3 by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

(2021) Tao Wan et al.   Science Advances

Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

(2021) Jin Yang et al.   Advanced Science

Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy

(2021) Tzu-Chieh Ho et al.   Science Advances

CRISPR/Cas9‐2D Silicene Gene‐Editing Nanosystem for Remote NIR‐II‐Induced Tumor Microenvironment Reprogramming and Augmented Photonic Tumor Ablation

(2021) Haohao Yin et al.   ADVANCED FUNCTIONAL MATERIALS

All‐In‐One Dendrimer‐Based Lipid Nanoparticles Enable Precise HDR‐Mediated Gene Editing In Vivo

(2021) Lukas Farbiak et al.   ADVANCED MATERIALS

Sono‐Controllable and ROS‐Sensitive CRISPR‐Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy

(2021) Yinying Pu et al.   ADVANCED MATERIALS

Hypoxia‐Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild‐Photothermal Therapy

(2021) Xueqing Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Gene Delivery and CRISPR/Cas9 Homology-Directed Repair in Serum by Minimally Succinylated Polyethylenimine

(2021) Nasir Uddin et al.   MOLECULAR PHARMACEUTICS

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Supramolecular Nanosubstrate‐Mediated Delivery for CRISPR/Cas9 Gene Disruption and Deletion

(2021) Qian Ban et al.   Small

Reduction‐Sensitive Fluorinated‐Pt(IV) Universal Transfection Nanoplatform Facilitating CT45‐Targeted CRISPR/dCas9 Activation for Synergistic and Individualized Treatment of Ovarian Cancer

(2021) Hongtong Lu et al.   Small

A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapies

(2021) Ehsan Razeghian et al.   Stem Cell Research & Therapy

Constructing Well-Defined and Robust Th-MOF-Supported Single-Site Copper for Production and Storage of Ammonia from Electroreduction of Nitrate

(2021) Zhi Gao et al.   ACS Central Science

Efficient Peptide-Mediated In Vitro Delivery of Cas9 RNP

(2021) Oskar Gustafsson et al.   Pharmaceutics

Synergistic photothermal cancer immunotherapy by Cas9 ribonucleoprotein-based copper sulfide nanotherapeutic platform targeting PTPN2

(2021) Tao Yan et al.   BIOMATERIALS

Localized delivery of immunotherapeutics: A rising trend in the field

(2021) Jie Wang et al.   JOURNAL OF CONTROLLED RELEASE

Cas9 conjugate complex delivering donor DNA for efficient gene editing by homology-directed repair

(2021) Yoo Kyung Kang et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration

(2021) Qingtao Li et al.   Bioactive Materials

Efficient CRISPR/Cas9 Gene-chemo Synergistic Cancer Therapy via a Stimuli-Responsive Chitosan-Based Nanocomplex Elicits Anti-Tumorigenic Pathway Effect

(2020) Bingchen Zhang et al.   CHEMICAL ENGINEERING JOURNAL

Cell-Type-Specific CRISPR/Cas9 Delivery by Biomimetic Metal Organic Frameworks

(2020) Mram Z. Alyami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing

(2020) Xiaohong Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Reshaping Tumor Immune Microenvironment through Acidity-Responsive Nanoparticles Featured with CRISPR/Cas9-Mediated Programmed Death-Ligand 1 Attenuation and Chemotherapeutics-Induced Immunogenic Cell Death

(2020) Kun Tu et al.   ACS Applied Materials & Interfaces

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

(2020) Ranjith Kumar Kankala et al.   ADVANCED MATERIALS

Aptamer/Peptide‐Functionalized Genome‐Editing System for Effective Immune Restoration through Reversal of PD‐L1‐Mediated Cancer Immunosuppression

(2020) Xiao‐Yan He et al.   ADVANCED MATERIALS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Polymeric vehicles for nucleic acid delivery

(2020) Alexandra S. Piotrowski-Daspit et al.   ADVANCED DRUG DELIVERY REVIEWS

Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy

(2020) Tao Wan et al.   JOURNAL OF CONTROLLED RELEASE

A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries

(2020) Yuyuan Wang et al.   JOURNAL OF CONTROLLED RELEASE

A Lactose‐Derived CRISPR/Cas9 Delivery System for Efficient Genome Editing In Vivo to Treat Orthotopic Hepatocellular Carcinoma

(2020) Yu Qi et al.   Advanced Science

Appropriate Delivery of the CRISPR/Cas9 System through the Nonlysosomal Route: Application for Therapeutic Gene Editing

(2020) Hang Yin et al.   Advanced Science

Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects

(2020) Shaohui Deng et al.   Science Advances

Multistage Sensitive NanoCRISPR Enable Efficient Intracellular Disruption of Immune Checkpoints for Robust Innate and Adaptive Immune Coactivation

(2020) Ning Wang et al.   ADVANCED FUNCTIONAL MATERIALS

A Versatile Nonviral Delivery System for Multiplex Gene‐Editing in the Liver

(2020) Jing Gong et al.   ADVANCED MATERIALS

Pioneers of revolutionary CRISPR gene editing win chemistry Nobel

(2020) Heidi Ledford et al.   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Supramolecular nanosubstrate–mediated delivery system enables CRISPR-Cas9 knockin of hemoglobin beta gene for hemoglobinopathies

(2020) Peng Yang et al.   Science Advances

Clustered Regularly Interspaced Short Palindromic Repeats-Mediated Surface-Enhanced Raman Scattering Assay for Multidrug-Resistant Bacteria

(2020) Hongki Kim et al.   ACS Nano

Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein Delivery

(2020) Ji Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Binding‐mediated formation of ribonucleoprotein corona for efficient delivery and control of CRISPR‐Cas9

(2020) Jinjun Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PLGA-Nanoparticles for Intracellular Delivery of the CRISPR-Complex to Elevate Fetal Globin Expression in Erythroid Cells

(2020) Luis J. Cruz et al.   BIOMATERIALS

Delivery of CRISPR/Cas9 Plasmids by Cationic Gold Nanorods: Impact of the Aspect Ratio on Genome Editing and Treatment of Hepatic Fibrosis

(2020) Yuxuan Chen et al.   CHEMISTRY OF MATERIALS

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing

(2019) Xiaoti Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microenvironment-Responsive Delivery of the Cas9 RNA-Guided Endonuclease for Efficient Genome Editing

(2019) Jun Yin et al.   BIOCONJUGATE CHEMISTRY

Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing

(2019) Yuan Rui et al.   ACS Applied Materials & Interfaces

Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations

(2019) Reza Shahbazi et al.   NATURE MATERIALS

Structure and Magnetic Properties of Cu-Doped LiFePO4 Olivine-Type Material Prepared by Sol–Gel

(2019) Qing Lin et al.   Science of Advanced Materials

Near-infrared upconversion–activated CRISPR-Cas9 system: A remote-controlled gene editing platform

(2019) Yongchun Pan et al.   Science Advances

Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

(2019) Ji Liu et al.   ADVANCED MATERIALS

Triple-Targeting Delivery of CRISPR/Cas9 to Reduce the Risk of Cardiovascular Diseases

(2019) Lingmin Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A boronic acid–rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing

(2019) Chongyi Liu et al.   Science Advances

Nanostructured Materials for Intracellular Cargo Delivery

(2019) Andy Tay et al.   ACCOUNTS OF CHEMICAL RESEARCH

A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing

(2019) Guojun Chen et al.   Nature Nanotechnology

Therapeutic genome editing of triple-negative breast tumors using a noncationic and deformable nanolipogel

(2019) Peng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid

(2019) Qiao Tang et al.   ACS Applied Materials & Interfaces

A Photolabile Semiconducting Polymer Nanotransducer for Near-Infrared Regulation of CRISPR/Cas9 Gene Editing

(2019) Yan Lyu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Self-Assembled Platform Based on Branched DNA for sgRNA/Cas9/Antisense Delivery

(2019) Jianbing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Universal GSH-Responsive Nanoplatform for the Delivery of DNA, mRNA, and Cas9/sgRNA Ribonucleoprotein

(2018) Guojun Chen et al.   ACS Applied Materials & Interfaces

Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles

(2018) Ying-Li Luo et al.   ACS Nano

Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy

(2018) Peng Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Active Intracellular Delivery of a Cas9/sgRNA Complex Using Ultrasound-Propelled Nanomotors

(2018) Malthe Hansen-Bruhn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dual-Targeting Delivery System for Effective Genome Editing and In Situ Detecting Related Protein Expression in Edited Cells

(2018) Bo-Ya Liu et al.   BIOMACROMOLECULES

Delivering CRISPR: a review of the challenges and approaches

(2018) Christopher A. Lino et al.   DRUG DELIVERY

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

(2018) Romain Rouet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cationic Polymer-Mediated CRISPR/Cas9 Plasmid Delivery for Genome Editing

(2018) Zhen Zhang et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Graphene oxide-mediated Cas9/sgRNA delivery for efficient genome editing

(2018) Huahua Yue et al.   Nanoscale

Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos

(2018) Bin Gu et al.   NATURE BIOTECHNOLOGY

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

(2018) Hong-Xia Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

CRISPR/Cas9 for cancer research and therapy

(2018) Tianzuo Zhan et al.   SEMINARS IN CANCER BIOLOGY

Structural absorption by barbule microstructures of super black bird of paradise feathers

(2018) Dakota E. McCoy et al.   Nature Communications

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

HPV Oncogene Manipulation Using Nonvirally Delivered CRISPR/Cas9 or Natronobacterium gregoryi Argonaute

(2018) Yeh-Hsing Lao et al.   Advanced Science

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

(2018) Bumwhee Lee et al.   Nature Biomedical Engineering

Versatile Redox-Responsive Polyplexes for the Delivery of Plasmid DNA, Messenger RNA, and CRISPR-Cas9 Genome-Editing Machinery

(2018) Yuyuan Wang et al.   ACS Applied Materials & Interfaces

Silicene, silicene derivatives, and their device applications

(2018) Alessandro Molle et al.   CHEMICAL SOCIETY REVIEWS

Fluorinated Acid-Labile Branched Hydroxyl-Rich Nanosystems for Flexible and Robust Delivery of Plasmids

(2018) Yu Qi et al.   Small

Synthesis and Evaluation of pH-Sensitive Multifunctional Lipids for Efficient Delivery of CRISPR/Cas9 in Gene Editing

(2018) Da Sun et al.   BIOCONJUGATE CHEMISTRY

Improved Delivery of CRISPR/Cas9 System Using Magnetic Nanoparticles into Porcine Fibroblast

(2018) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets

(2018) Haibao Zhu et al.   Nature Biomedical Engineering

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal Escape and Delivery of CRISPR/Cas9 Genome Editing Machinery Enabled by Nanoscale Zeolitic Imidazolate Framework

(2017) Shahad K. Alsaiari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

(2017) Xue Gao et al.   NATURE

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice

(2016) Ling Li et al.   ACS Nano

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

Knock-in of large reporter genes in human cells via CRISPR/Cas9-induced homology-dependent and independent DNA repair

(2016) Xiangjun He et al.   NUCLEIC ACIDS RESEARCH

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

(2016) Ming Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors

(2015) Xiaoling Wang et al.   NATURE BIOTECHNOLOGY

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

(2014) Guanying Chen et al.   CHEMICAL REVIEWS

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system

(2014) Danilo Maddalo et al.   NATURE

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

(2014) Hao Yin et al.   NATURE BIOTECHNOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

History of gene therapy

(2013) Thomas Wirth et al.   GENE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Silicene: Compelling Experimental Evidence for Graphenelike Two-Dimensional Silicon

(2012) Patrick Vogt et al.   PHYSICAL REVIEW LETTERS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS