Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis

Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/Parkin-mediated mitophagy

(2021) Junxiao Xi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Apelin-36 Protects HT22 Cells Against Oxygen-Glucose Deprivation/Reperfusion-Induced Oxidative Stress and Mitochondrial Dysfunction by Promoting SIRT1-Mediated PINK1/Parkin-Dependent Mitophagy

(2021) Ziqi Shao et al.   NEUROTOXICITY RESEARCH

A decision-neuroscientific intervention to improve cognitive recovery after stroke

(2021) Bettina Studer et al.   BRAIN

Inhibition of extracellular signal-regulated kinase/calpain-2 pathway reduces neuroinflammation and necroptosis after cerebral ischemia-reperfusion injury in a rat model of cardiac arrest

(2021) Wen-yan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury

(2021) Ke Chen et al.   Frontiers in Pharmacology

miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway

(2021) Feng Zhou et al.   Journal of Neuroinflammation

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

(2021) Huxinyue Duan et al.   PHARMACOLOGICAL RESEARCH

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics

(2021) Amir Ajoolabady et al.   PHARMACOLOGY & THERAPEUTICS

Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1/Parkin-induced mitochondrial ubiquitination in adult rats

(2021) Haixia Wen et al.   Cell Death & Disease

Outcome after acute ischemic stroke is linked to sex-specific lesion patterns

(2021) Anna K. Bonkhoff et al.   Nature Communications

Protective mechanism of Erigeron breviscapus injection on blood–brain barrier injury induced by cerebral ischemia in rats

(2021) Guangli Liu et al.   Scientific Reports

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

(2021) Li Lei et al.   Frontiers in Aging Neuroscience

Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of Erigeron breviscapus

(2021) Ruixia Wu et al.   Frontiers in Pharmacology

Dengzhanxixin Injection Ameliorates Cognitive Impairment Through a Neuroprotective Mechanism Based on Mitochondrial Preservation in Patients With Acute Ischemic Stroke

(2021) Haiting An et al.   Frontiers in Pharmacology

Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43

(2021) Tingting Zhang et al.   Frontiers in Cell and Developmental Biology

Ischaemic stroke in young adults: a global perspective

(2020) Esther Boot et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

(2020) Alessandro Luciani et al.   Nature Communications

Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial

(2020) Ming-zhe Hu et al.   Chinese Journal of Integrative Medicine

β -Glucuronidase- and OATP2B1-mediated drug interaction of scutellarin in Dengzhan Xixin Injection: A formulation aspect

(2020) Jinxin Shi et al.   DRUG DEVELOPMENT RESEARCH

Sanggenon C Ameliorates Cerebral Ischemia-Reperfusion Injury by Inhibiting Inflammation and Oxidative Stress through Regulating RhoA-ROCK Signaling

(2020) Yilei Zhao et al.   INFLAMMATION

Cell Death Pathways in Ischemic Stroke and Targeted Pharmacotherapy

(2020) Aishika Datta et al.   Translational Stroke Research

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

(2020) Yangxin Li et al.   Frontiers in Pharmacology

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

(2020) Man Wu et al.   ACTA PHARMACOLOGICA SINICA

The conditioned medium of human embryonic stem cell‐derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke

(2020) Afsaneh Asgari Taei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PK-PD Correlation of Erigeron Breviscapus Injection in the Treatment of Cerebral Ischemia-Reperfusion Injury Model Rats

(2020) Guangli Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

JLX001 attenuates blood-brain barrier dysfunction in MCAO/R rats via activating the Wnt/β-catenin signaling pathway

(2020) Bo Zhao et al.   LIFE SCIENCES

Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats

(2020) Shaoxun Wang et al.   GeroScience

Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety

(2020) Fangfang Fan et al.   BIOMEDICINE & PHARMACOTHERAPY

tPA Mobilizes Immune Cells that Exacerbate Hemorrhagic Transformation in Stroke

(2020) Kaibin Shi et al.   CIRCULATION RESEARCH

ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats

(2020) Dongyun Zhang et al.   EXPERIMENTAL NEUROLOGY

GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation

(2020) Hui Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage

(2020) Takahiko Imai et al.   NEUROSCIENCE

Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology

(2020) Chenglin Mu et al.   Journal of Functional Foods

Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink

(2020) Alexey S. Ladokhin   Cells

Protosappanin A Maintains Neuronal Mitochondrial Homeostasis through Promoting Autophagic Degradation of Bax

(2020) Li-Xi Liao et al.   ACS Chemical Neuroscience

Benzoinum from Styrax tonkinensis (Pierre) Craib ex Hart exerts a NVU protective effect by inhibiting cell apoptosis in cerebral ischaemia rats

(2020) Qian Xie et al.   JOURNAL OF ETHNOPHARMACOLOGY

The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons

(2020) Md. Nazmul Haque et al.   PHYTOMEDICINE

FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury

(2020) Ying Cai et al.   Redox Biology

Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway

(2020) Alaaeldin Ahmed Hamza et al.   BIOMEDICINE & PHARMACOTHERAPY

Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain injury in mice by restoration of cerebrovascular function

(2020) Ning Li et al.   JOURNAL OF ETHNOPHARMACOLOGY

Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association

(2019) Donna M. Ferriero et al.   STROKE

The global burden of stroke: persistent and disabling

(2019) Philip B Gorelick   LANCET NEUROLOGY

Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway

(2019) Xiaobo Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Acute ischaemic stroke: challenges for the intensivist

(2019) M. Smith et al.   INTENSIVE CARE MEDICINE

Microfluidic chip and its application in autophagy detection

(2019) Xiaobo Wang et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Beneficial Effects of Theta-Burst Transcranial Magnetic Stimulation on Stroke Injury via Improving Neuronal Microenvironment and Mitochondrial Integrity

(2019) Xuemei Zong et al.   Translational Stroke Research

Qingkailing injection ameliorates cerebral ischemia-reperfusion injury and modulates the AMPK/NLRP3 Inflammasome Signalling pathway

(2019) Chongyang Ma et al.   BMC Complementary and Alternative Medicine

Longzhibu disease and its therapeutic effects by traditional Tibetan medicine: Ershi-wei Chenxiang pills

(2019) Ya Hou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion

(2019) Huanyuan Wang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway

(2018) Xinwei Wu et al.   BRAIN RESEARCH

Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats

(2018) Jing Yu et al.   EXPERIMENTAL NEUROLOGY

Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury

(2018) Chengli Ling et al.   MOLECULES

Diverse roles of mitochondria in ischemic stroke

(2018) Jenq-Lin Yang et al.   Redox Biology

Heat Shock Protein B8 (HSPB8) Reduces Oxygen-Glucose Deprivation/Reperfusion Injury via the Induction of Mitophagy

(2018) Fazhao Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia

(2018) Yueyang Liu et al.   Autophagy

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress

(2016) Mohammed Akbar et al.   BRAIN RESEARCH

Caffeoylquinic Acid Derivatives Protect SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide-Induced Injury Through Modulating Oxidative Status

(2016) Xiao-Wen Jiang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in rats

(2016) Qipeng Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antitumor activity of 4-O-(2″-O-acetyl-6″-O-p-coumaroyl-β-d-glucopyranosyl)-p-coumaric acid against lung cancers via mitochondrial-mediated apoptosis

(2015) Wei Peng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Defective Autophagosome Formation in p53-Null Colorectal Cancer Reinforces Crocin-Induced Apoptosis

(2015) Amr Amin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acute Stroke Intervention

(2015) Shyam Prabhakaran et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Texture analysis of liver fibrosis microscopic images: a study on the effect of biomarkers

(2011) A. Amin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Protective Effects of Scutellarin Against Cerebral Ischemia in Rats: Evidence for Inhibition of the Apoptosis-Inducing Factor Pathway

(2008) Hua-Feng Zhang et al.   PLANTA MEDICA