Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria

(2018) Noémie Remacle et al.   MOLECULAR GENETICS AND METABOLISM

Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

(2018) Beatrice Paola Festa et al.   Nature Communications

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease

(2018) Md Fakruddin et al.   Cell Reports

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology

(2018) Fenglei Jian et al.   Cell Reports

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Linking cellular stress responses to systemic homeostasis

(2018) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

(2017) Chang-Ki Oh et al.   Cell Reports

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction

(2017) Mohamed A. Elmonem et al.   Scientific Reports

Methylmalonic and propionic acidemias

(2016) Jamie L. Fraser et al.   CURRENT OPINION IN PEDIATRICS

Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect

(2016) Patrick Forny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

(2016) Francesco Emma et al.   Nature Reviews Nephrology

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

Mitochondria–Power Players in Kidney Function?

(2016) Josephine M. Forbes   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells

(2015) Benoit Pasquier   Autophagy

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Impaired Lysosomal Function Underlies Monoclonal Light Chain-Associated Renal Fanconi Syndrome

(2015) A. Luciani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric Tubule

(2015) Francesca Oltrabella et al.   PLoS Genetics

Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis

(2014) D. Carrella et al.   BIOINFORMATICS

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

Formoterol Restores Mitochondrial and Renal Function after Ischemia-Reperfusion Injury

(2014) S. R. Jesinkey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Proposed guidelines for the diagnosis and management of methylmalonic and propionic acidemia

(2014) Matthias R Baumgartner et al.   Orphanet Journal of Rare Diseases

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia

(2013) I. Manoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development

(2011) Esther Kur et al.   DEVELOPMENTAL DYNAMICS

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

The role of mitochondria in health and disease

(2009) Darcy L Johannsen et al.   CURRENT OPINION IN PHARMACOLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energetics, epigenetics, mitochondrial genetics

(2009) Douglas C. Wallace et al.   MITOCHONDRION

Mitochondrial dysfunction in mut methylmalonic acidemia

(2008) Randy J. Chandler et al.   FASEB JOURNAL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE